1. Ammonyx Lo
2. Ddao
3. Dodecyldimethylamine N-oxide
4. Dodecyldimethylamine Oxide
5. Hexyldimethylamine Oxide
6. Lauryldimethylamine Oxide
7. Ldao
8. N,n-dimethyldodecyclamine N-oxide
9. N,n-dimethyldodecylamine-n-oxide
10. N-dodecyl-n,n-dimethylamine N-oxide
1. 1643-20-5
2. Lauryldimethylamine Oxide
3. Dodecyldimethylamine Oxide
4. Lauryldimethylamine N-oxide
5. 1-dodecanamine, N,n-dimethyl-, N-oxide
6. Ldao
7. N,n-dimethyldodecan-1-amine Oxide
8. Ammonyx Ao
9. Empigen Ob
10. Ammonyx Lo
11. Aromox Dmcd
12. Conco Xal
13. Dimethylaurylamine Oxide
14. N,n-dimethyldodecylamine N-oxide
15. Dimethyldodecylamine Oxide
16. N-dodecyldimethylamine Oxide
17. Dimethyldodecylamine N-oxide
18. Dodecyldimethylamine N-oxide
19. Dodecyl(dimethyl)amine Oxide
20. Ddno
21. N,n-dimethyldodecylamine-n-oxide
22. Lauryl Dimethylamine-n-oxide
23. Dimethyllaurylamine Oxide
24. N,n-dimethyldodecylamine Oxide
25. N,n-dimethyl-1-dodecylamine N-oxide
26. Laurylamine Oxide
27. Lauryl Dimethyl Amine Oxide
28. N,n-dimethyl-1-dodecanamine-n-oxide
29. 4f6fc4mi8w
30. Amine Oxide, Dodecyl(dimethyl)-
31. Chembl1233973
32. Aromox Dmmc-w
33. Amonyx Ao
34. Refan [russian]
35. N,n-dimethyldodecylamine N-oxide 30% Solution In H2o
36. Refan
37. N-lauryldimethylamine N-oxide
38. Hsdb 5451
39. N-lauryl-n,n-dimethylamine Oxide
40. Nci-c55129
41. Einecs 216-700-6
42. N,n-dimethyl-dodecylaminoxid [czech]
43. Oxyde De Dimethyllaurylamine [french]
44. Unii-4f6fc4mi8w
45. Dodecylamine, N,n-dimethyl-, N-oxide
46. Oxyde De Dimethyllaurylamine
47. Brn 1769927
48. N,n-dimethyl-dodecylaminoxid
49. 1-dodecanamine, N,n-dimethl-, N-oxide
50. N,n-dimethyldodecanamine Oxide
51. Cyclomox L
52. Rhodamox L
53. Softamine L
54. Genaminox La
55. Schercamox Dml
56. Rhodamox Lo
57. Oxamin Lo
58. Emcol L
59. Incromine Oxide L
60. Emcol Lo
61. Unisafe A-lm
62. Amphitol 20n
63. Barlox 12i
64. Mfcd00002049
65. N,n-dimethyldodecan-1-amine N-oxide
66. Rewominox L 408
67. Ammonyx Dmcd 40
68. Admox 12
69. Aromox Dm 12d
70. Aromox Dm 12w
71. Oxidet Dm 20
72. Euroxide Lo
73. Aromox Dm 12d-w
74. Emal 20n
75. Imethylauroylamine Oxide
76. Atlas Cd 413
77. Tomah Ao 728
78. Aromox Dm 12dw(c)
79. Ammonyx C10 Amine Oxide
80. Lauryldimethylamine-n-oxide
81. Ec 216-700-6
82. N,n-dimethyl Lauramine Oxide
83. Schembl27337
84. Lauramine Oxide [ii]
85. 4-04-00-00798 (beilstein Handbook Reference)
86. Lauramine Oxide [hsdb]
87. Lauramine Oxide [inci]
88. Dtxsid1020514
89. Chebi:131762
90. (c10-16)alkyldimethylamine Oxide
91. 101cg
92. Zinc2039372
93. Bdbm50327308
94. Akos015904034
95. Db04147
96. Ncgc00164286-01
97. N,n-dimethyldodecylamine N-oxide Solution
98. Lauryldimethylamine Oxide / Lauramine Oxide
99. Ft-0689256
100. L0361
101. D78505
102. 1-dodecanamine, N,n-dimethyl-, N-oxide (9ci)
103. Ldao, N,n-dimethyldodecylamine N-oxide, Powder
104. Dodecylamine, N,n-dimethyl-, N-oxide (6ci,8ci)
105. N,n-dimethyldodecylamine N-oxide 100 Mm Solution
106. J-010130
107. J-521637
108. Q6501952
109. N,n-dimethyldodecylamine N-oxide (ca. 30% In Water)
110. N,n-dimethyldodecylamine N-oxide, >=99% (titration)
111. N,n-dimethyldodecylamine N-oxide Solution, ~30% In H2o
112. N,n-dimethyldodecylamine N-oxide, Bioxtra, >=99.0% (nt)
113. N,n-dimethyldodecylamine N-oxide Solution, Bioultra, ~0.1 M In H2o
| Molecular Weight | 229.40 g/mol |
|---|---|
| Molecular Formula | C14H31NO |
| XLogP3 | 5.3 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 11 |
| Exact Mass | 229.240564612 g/mol |
| Monoisotopic Mass | 229.240564612 g/mol |
| Topological Polar Surface Area | 18.1 Ų |
| Heavy Atom Count | 16 |
| Formal Charge | 0 |
| Complexity | 146 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Surface-Active Agents
Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics. (See all compounds classified as Surface-Active Agents.)
Detergents
Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties. (See all compounds classified as Detergents.)
(1-Dodecyl-14C)lauramine oxide (10 mg with 100 uCi of 14C) was applied to the skin of two humans to study cutaneous absorption and metabolism of lauramine oxide. Ninety-two percent of the applied radioactivity was recovered from the skin of the test subjects 8 hr after dosing, and 0.1 and 0.23% of the radioactivity was recovered from the excretion products of the test subjects. The stratum corneum contained <0.2% of the applied dose.
Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 231-45 (1994)
Oral administration of a solution containing 50 mg (1-dodecyl-14C)lauramine oxide (100 uCi of 14C) to two humans resulted in excretion patterns of radioactivity similar to that of the other species studied. Fifty percent and 37% of the radioactivity was found in the urine within 24 hr of dosing, and expired 14C02 contained between 18 and 22% of the radioactivity administered.
Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 231-45 (1994)
Four Sprague-Dawley rats were given intraperitoneal injections of 22 mg (methyl-14C)lauramine oxide kg (specific activity 1.3 mCi/g). Sixty-seven percent of the total radioactivity was eliminated in the urine, 8% was expired as I4CO2, and 6% was eliminated in the feces within 24 hr. The distribution of radioactivity was essentially the same as that seen in rats given oral doses of lauramine oxide. The conclusion was that "... microbial metabolism by gastrointestinal flora does not play a major role in the absorption and excretion of [lauramine oxide] in rats."
Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 231-45 (1994)
Aqueous (methyl-14C)lauramine oxide (10 mg containing 1.3 mCi/g) was applied to the skin of four Sprague-Dawley rats to test metabolism and absorption of the compound. Over 72 hr, 14.2% of the total radioactivity was found in the urine, 2.5% in the CO2, and 1.8% in the feces. Radioactivity was detected in the liver, kidneys, testes, blood, and expired CO2.
Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 231-45 (1994)
For more Absorption, Distribution and Excretion (Complete) data for LAURAMINE OXIDE (7 total), please visit the HSDB record page.
Metabolic profiles for different species (rat, human, mouse, rabbit) did not have any significant differences in metabolites, but the degree of absorption, especially in cutaneous applications, varied from species to species.
Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 231-45 (1994)
Characterization of metabolites of lauramine oxide resulted in the positive identification of only one metabolite, N-dimethyl-4-aminobutyric acid N-oxide. Several pathways exist for metabolism of lauramine oxide: omega,beta-oxidation of alkyl chains (the most common pathway for surfactant metabolism), hydroxylation of alkyl chains, and reduction of the amine oxide group.
Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 231-45 (1994)
Urinary metabolites in rats, rabbits and humans suggested metabolism via omega, beta-oxidation of the aliphatic chain, amine oxide reduction and aliphatic, mid-chain hydroxylation. N,N-dimethyl-4-aminobutyric acid and its N-oxide accounted for 28, 28 and 23% in man, rats and rabbits, respectively.
PMID:7293233 Turan et al; Xenobiotica 11 (7): 447 (1981)
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