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    Lercanidipine HCl

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    MARKET PLACE

    PharmaCompass
    $ API Ref.Price (USD/KG) : 1,439Xls

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    2D Structure
    Also known as: 132866-11-6, Lercanidipine hcl, Cardiovasc, Corifeo, Carmen, Lercadip
    Molecular Formula
    C36H42ClN3O6
    Molecular Weight
    648.2  g/mol
    InChI Key
    WMFYOYKPJLRMJI-UHFFFAOYSA-N
    FDA UNII
    OA8TFX68PE
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride
    2.1.2 InChI
    InChI=1S/C36H41N3O6.ClH/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27;/h7-19,22,30,33,37H,20-21,23H2,1-6H3;1H
    2.1.3 InChI Key
    WMFYOYKPJLRMJI-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(C(C(=C(N1)C)C(=O)OC(C)(C)CN(C)CCC(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    OA8TFX68PE
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Lercadip

    2. Lercanidipine

    3. Lerdip

    4. Methyl-1,1-dimethyl-2-(n-(3,3-diphenylpropyl)-n-methylamino)ethyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

    5. Rec 15-2375

    6. Rec-15-2375

    7. Zanidip

    2.3.2 Depositor-Supplied Synonyms

    1. 132866-11-6

    2. Lercanidipine Hcl

    3. Cardiovasc

    4. Corifeo

    5. Carmen

    6. Lercadip

    7. Lerzam

    8. Lercan

    9. Rec-15/2375

    10. Lercanidipine (hydrochloride)

    11. Lercanidipine Hydrochloride Hemihydrate

    12. 3-(1-((3,3-diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride

    13. Lercanidipine Hydrochloride [usan]

    14. Oa8tfx68pe

    15. 100427-27-8

    16. 5-o-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-o-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride

    17. Lercapin

    18. Lercaton

    19. Lerkamen

    20. Renovia

    21. Vasodip

    22. Zanicor

    23. Zandip

    24. Dsstox_cid_26665

    25. Dsstox_rid_81807

    26. Dsstox_gsid_46665

    27. Zanidip

    28. (r)-lercanidipine (hydrochloride)

    29. (s)-lercanidipine (hydrochloride)

    30. Lerdip

    31. 2-((3,3-diphenylpropyl)methylamino)-1,1-dimethylethyl Methyl (4rs)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Monohydrochloride

    32. 3,5-pyridinedicarboxylic Acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-((3,3-diphenylpropyl)methylamino)-1,1-dimethylethyl Methyl Ester, Monohydrochloride

    33. 3-(1-((3,3-diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride(1:x)

    34. Cas-132866-11-6

    35. Lercanidipinehcl

    36. Zanidip (hydrochloride)

    37. Ncgc00167492-01

    38. Unii-oa8tfx68pe

    39. Masnidipine (hydrochloride)

    40. R 75

    41. Zanedip

    42. Cardiovasc (tn)

    43. Lcp-lerc

    44. Zanidip Hydrochloride

    45. Masnidipine Hydrochloride

    46. Schembl217099

    47. Chembl2106419

    48. Dtxsid3046665

    49. Chebi:31771

    50. Hy-b0612a

    51. Lercanidipine-[d3] Hydrochloride

    52. Tjn-324

    53. Lercanidipine Hydrochloride (1:x)

    54. Lercanidipine Hydrochloride- Bio-x

    55. Bcp11375

    56. Tox21_112493

    57. Tox21_500144

    58. Mfcd07773089

    59. S4597

    60. Akos015846519

    61. Tox21_112493_1

    62. Ac-1420

    63. Ccg-221448

    64. Ccg-270327

    65. Lp00144

    66. Lercanidipine Hydrochloride (jan/usan)

    67. Lercanidipine Hydrochloride [mi]

    68. Lercanidipine Hydrochloride [jan]

    69. Ncgc00167492-03

    70. Ncgc00260829-01

    71. As-13358

    72. Bl164618

    73. Lercanidipine Hydrochloride [mart.]

    74. Db-042142

    75. Lercanidipine Hydrochloride [who-dd]

    76. Ft-0627794

    77. Ft-0631144

    78. Ft-0670749

    79. Ft-0670750

    80. L0282

    81. Lercanidipine Hydrochloride, >=98% (hplc)

    82. D01849

    83. 866l116

    84. A806509

    85. J-006235

    86. J-006236

    87. J-521641

    88. Q27285537

    89. 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[(3,3-diphenylpropyl)

    90. 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic Acid O5-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] Ester O3-methyl Ester Hydrochloride

    91. 3,3-diphenylpropyl-[2-[5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carbonyl]oxy-2-methylpropyl]-methylazanium;chloride

    92. 3,5-pyridinedicarboxylic Acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(3,3-diphenylpropyl)methylamino)-1,1-dimethylethyl Methyl Ester, Monohydrochloride

    93. 3,5-pyridinedicarboxylic Acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl Ester, Hydrochloride (1:1)

    94. O5-[1-[3,3-diphenylpropyl(methyl)amino]-2-methyl-propan-2-yl] O3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 648.2 g/mol
    Molecular Formula C36H42ClN3O6
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count13
    Exact Mass647.2762138 g/mol
    Monoisotopic Mass647.2762138 g/mol
    Topological Polar Surface Area114 Ų
    Heavy Atom Count46
    Formal Charge0
    Complexity1090
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Calcium Channel Blockers

    A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)