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    Levodropropizine

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: 99291-25-5, (s)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol, Levotuss, Danka, (-)-dropropizine, Levdropropizine
    Molecular Formula
    C13H20N2O2
    Molecular Weight
    236.31  g/mol
    InChI Key
    PTVWPYVOOKLBCG-ZDUSSCGKSA-N
    FDA UNII
    3O31P6T4G3
    Levodropropizine is under investigation in clinical trial NCT01573663 (A Drug-Drug Interaction Study of Ambroxol and Levodropropizine).
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol
    2.1.2 InChI
    InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2/t13-/m0/s1
    2.1.3 InChI Key
    PTVWPYVOOKLBCG-ZDUSSCGKSA-N
    2.1.4 Canonical SMILES
    C1CN(CCN1CC(CO)O)C2=CC=CC=C2
    2.1.5 Isomeric SMILES
    C1CN(CCN1C[C@@H](CO)O)C2=CC=CC=C2
    2.2 Other Identifiers
    2.2.1 UNII
    3O31P6T4G3
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Df 526

    2. Df-526

    3. Dipropizine

    4. Dipropizine, (s)-isomer

    5. Ditustat

    6. Dropropizine

    7. Levotuss

    8. Tautoss

    9. Zyplo

    2.3.2 Depositor-Supplied Synonyms

    1. 99291-25-5

    2. (s)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol

    3. Levotuss

    4. Danka

    5. (-)-dropropizine

    6. Levdropropizine

    7. (s)-(-)-dropropizine

    8. Rapitux

    9. Levodropropizina

    10. (2s)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol

    11. Levodropropizinum

    12. Levopront

    13. Levodropropizine [inn]

    14. L-dropropizine

    15. Dipropizine, (s)-isomer

    16. 99291-24-4

    17. Dropropizine, (s)-

    18. (-)-(s)-3-(4-phenyl-1-piperazinyl)-1,2-propanediol

    19. 1,2-propanediol, 3-(4-phenyl-1-piperazinyl)-, (2s)-

    20. Chebi:82722

    21. 3o31p6t4g3

    22. Df-526

    23. Levodropropizine (inn)

    24. Dropropizine S-form

    25. Levodropropizinum [inn-latin]

    26. Levodropropizina [inn-spanish]

    27. Df 526

    28. Levodropropizine [inn:ban]

    29. Salvituss

    30. Unii-3o31p6t4g3

    31. Levopront (tn)

    32. (s)-3-(4-phenyl-1-piperazinyl)-1,2-propanediol

    33. Cas-17692-31-8

    34. S(-)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol

    35. Lvdp

    36. Levodropropizine Impurity A

    37. Schembl29043

    38. Chembl1288810

    39. Dtxsid8023210

    40. Levodropropizine [mart.]

    41. 1,2-propanediol, 3-(4-phenylpiperazin-1-yl)-, S(-)-

    42. Dropropizine S-form [mi]

    43. Levodropropizine [who-dd]

    44. Levodropropizine (s-dropropizine)

    45. Hms3885b07

    46. Hy-b1895

    47. Bbl036696

    48. Mfcd00866852

    49. S4131

    50. Stl559075

    51. Zinc19594545

    52. Akos015889397

    53. Ac-2084

    54. Ac-8088

    55. Bcp9000850

    56. Ccg-266840

    57. Cs-5212

    58. Db12472

    59. Levodropropizine [ep Monograph]

    60. Ncgc00016730-01

    61. Ncgc00018230-01

    62. Ncgc00018230-06

    63. As-12822

    64. Bcp0726000048

    65. L0339

    66. D08119

    67. F15098

    68. 291l244

    69. A845991

    70. Ao-022/43512153

    71. Q408131

    72. Q-100916

    73. Brd-k83551379-001-02-6

    74. S-(-)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol

    75. (2s)-3-(4-phenyl-1-piperazinyl)-1,2-propanediol

    76. 1,2-propanediol, 3-(4-phenyl-1-piperazinyl)-, (s)-

    2.4 Create Date
    2005-07-07
    3 Chemical and Physical Properties
    Molecular Weight 236.31 g/mol
    Molecular Formula C13H20N2O2
    XLogP30.6
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count4
    Exact Mass236.152477885 g/mol
    Monoisotopic Mass236.152477885 g/mol
    Topological Polar Surface Area46.9 Ų
    Heavy Atom Count17
    Formal Charge0
    Complexity212
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antitussive Agents

    Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally. (See all compounds classified as Antitussive Agents.)

    4.2 ATC Code

    R - Respiratory system

    R05 - Cough and cold preparations

    R05D - Cough suppressants, excl. combinations with expectorants

    R05DB - Other cough suppressants

    R05DB27 - Levodropropizine