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Lidocaine Hydrochloride

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ACTIVE PHARMA INGREDIENTS

50 API Suppliers, 13 USDMF, 9 CEP/COS, 3 JDMF, 10 EU WC, 13 KDMF, 30 NDC API, 37 Listed Suppliers, $ API Reference Price

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4 Drugs in Development

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409 FDF Dossiers, 226 FDA Orange Book, 67 Europe, 63 Canada, 17 South Africa, 36 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

INJECTABLE;INJECTION - 4%, INJECTABLE;INJECTION - 1% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, INJECTABLE;INJECTION - 2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, INJECTABLE;INJECTION - 20% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, INJECTABLE;INJECTION - 4% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, INJECTABLE;INJECTION - 0.005MG/ML;0.5%, INJECTABLE;INJECTION - 0.005MG/ML;1%, INJECTABLE;INJECTION - 0.005MG/ML;1.5%, INJECTABLE;INJECTION - 0.005MG/ML;2%, INJECTABLE;INJECTION - 0.01MG/ML;1%, INJECTABLE;INJECTION - 0.01MG/ML;2%, INJECTABLE;INJECTION - 0.02MG/ML;2%, INJECTABLE;INJECTION - 0.5%, INJECTABLE;INJECTION - 1%, INJECTABLE;INJECTION - 1.5%, INJECTABLE;INJECTION - 2%, INJECTABLE;INJECTION - 1%, INJECTABLE;INJECTION - 2%, INJECTABLE;INJECTION - 1%, INJECTABLE;SPINAL - 5%, JELLY;TOPICAL - 2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, INJECTABLE;INJECTION - EQ 0.02MG BASE/ML;2%, INJECTABLE;INJECTION - EQ 0.01MG BASE/ML;2%

RELATED EXCIPIENT COMPANIES

6 Rochem International Inc, 12 SPI Pharma, 3 Seqens, 13 DKSH, 1 Jai Radhe Sales, 1 PMC Isochem, 1 Pharm-RX Chemical, 1 Boai NKY Pharmaceuticals Ltd, 8 Gangwal Healthcare, 19 Nanjing Well Pharmaceutical, 1 ACG Worldwide, 22 Actylis, 3 Aeon Procare, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 43 BASF, 1 Bioplus Life Sciences, 1 BioSpectra, 1 Clariant, 17 Corel Pharma Chem, 3 Doshion Polyscience, 5 Finar, 13 Gangwal Chemicals, 4 Ideal Cures Pvt Ltd, 2 Ingredion Pharma Solutions, 18 Kerry, 4 Kima Chemical, 6 Lonza Capsugel, 9 Lubrizol Life Science Health, 9 Microlex e.U, 3 Nanjing Bold Chemical, 2 Nippon Fine Chemical, 2 Nomisma Healthcare, 2 Novo Excipients, 1 Pharmatrans-Sanaq, 4 Pluviaendo, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 21 Roquette, 25 Seppic, 3 Shandong Focus Biotechnology Co., Ltd, 3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 4 Sigachi Industries, 3 The Dow Chemical Company, 1 Ulanqab Kema New Material, 2 Valens Pharmachem, 1 Zhejiang Huakang Pharmaceutical

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2 DATA COMPILATION #PharmaFlow, 60 NEWS #PharmaBuzz

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50 APIs, 15 FDF Dossiers

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4 US Patents

4 US Patents

REF. STANDARDS & IMPURITIES

1 EDQM, 1 USP, 1 Others

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Also known as: 73-78-9, Lidocaine hcl, Lidothesin, Xyloneural, Lignocaine hydrochloride, Lidocaine (hydrochloride)

Molecular Formula

C₁₄H₂₃ClN₂O

Molecular Weight

270.80 g/mol

InChI Key

IYBQHJMYDGVZRY-UHFFFAOYSA-N

FDA UNII

EC2CNF7XFP

A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride

2.1.2 InChI

InChI=1S/C14H22N2O.ClH/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H

2.1.3 InChI Key

IYBQHJMYDGVZRY-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.Cl

2.2 Other Identifiers

2.2.1 UNII

EC2CNF7XFP

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-(diethylamino)-n-(2,6-dimethylphenyl)acetamide

2. 2-2etn-2mephacn

3. Dalcaine

4. Lidocaine

5. Lidocaine Carbonate

6. Lidocaine Carbonate (2:1)

7. Lidocaine Hydrocarbonate

8. Lidocaine Monoacetate

9. Lidocaine Monohydrochloride

10. Lidocaine Monohydrochloride, Monohydrate

11. Lidocaine Sulfate (1:1)

12. Octocaine

13. Xylesthesin

14. Xylocaine

15. Xylocitin

16. Xyloneural

2.3.2 Depositor-Supplied Synonyms

1. 73-78-9

2. Lidocaine Hcl

3. Lidothesin

4. Xyloneural

5. Lignocaine Hydrochloride

6. Lidocaine (hydrochloride)

7. Lidocaton

8. Xylocard

9. Lidocaine Hydrochloride Anhydrous

10. Lidopen

11. Acetamide, 2-(diethylamino)-n-(2,6-dimethylphenyl)-, Monohydrochloride

12. Lta Ii Kit

13. Laryng-o-jet Kit

14. Ec2cnf7xfp

15. Linocaine Hydrochloride

16. Mls000069665

17. Laryngotracheal Anesthesia Kit

18. 2-(diethylamino)-n-(2,6-dimethylphenyl)acetamide Hydrochloride

19. 2-diethylamino-2',6'-acetoxylidide Hydrochloride

20. Alphacaine Hydrochloride

21. Nsc-757420

22. Smr000058468

23. Xylocaine (tn)

24. Alpha-diethylamino-2,6-acetoxylidine Hydrochloride

25. Laryng-o-jet

26. Omega-diethylamino-2,6-dimethylacetanilide Hydrochloride

27. Xilina Hydrochloride

28. 73-78-9 (hcl); 6108-05-0 (monohydrate)

29. Rucaina Hydrochloride

30. Xycaine Hydrochloride

31. Xylotox Hydrochloride

32. Duncaine Hydrochloride

33. Isicaine Hydrochloride

34. Lidocain Hydrochloride

35. Anestacon Hydrochloride

36. Gravocain Hydrochloride

37. Leostesin Hydrochloride

38. Xylocitin Hydrochloride

39. Lidothesin Hydrochloride

40. Xylestesin Hydrochloride

41. Glydo

42. Lidocaine Viscous

43. Pediatric Lta Kit

44. Chebi:50512

45. Xylocaine Preservative Free

46. Sr-01000000189

47. Unii-ec2cnf7xfp

48. Einecs 200-803-8

49. Xylocaine 4% Preservative Free

50. Xylocaine 5% W/ Glucose 7.5%

51. Lidocaine Hydrochloride Viscous

52. S 202

53. V 262

54. Xylocaine 1.5% W/ Dextrose 7.5%

55. Dalcaine (tn)

56. Prestwick_296

57. N-(diethylaminoacetyl)-2,6-dimethylaniline Hydrochloride

58. Lidoca Ne Hydrochloride

59. Lidocaine Hydrochloride Preservative Free

60. Opera_id_351

61. Lidocaine Hydrochloride In Plastic Container

62. Lidocaine Hydrochloride 0.2% In Dextrose 5%

63. Lidocaine Hydrochloride 0.4% In Dextrose 5%

64. Lidocaine Hydrochloride 5% And Dextrose 7.5%

65. Spectrum1500689

66. Chembl541521

67. Dtxsid4058782

68. Hy-b0185a

69. 2',6'-acetoxylidide, 2-(diethylamino)-, Monohydrochloride

70. Hms1568i21

71. Hms1921c22

72. Lidocaine Hydrochloride Preservative Free In Plastic Container

73. Pharmakon1600-01500689

74. Lidocaine Hydrochloride (jan/usp)

75. 2',6'-acetoxylidide, 2-(diethylamino)-, Hydrochloride

76. Bcp30473

77. Lidocaine Hydrochloride 0.2% In Dextrose 5% In Plastic Container

78. Lidocaine Hydrochloride 0.4% In Dextrose 5% In Plastic Container

79. Lidocaine Hydrochloride 0.8% In Dextrose 5% In Plastic Container

80. Tox21_500669

81. Ccg-39281

82. Lidocaine Hydrochloride [jan]

83. Lidocaine Hydrochloride 0.1% And Dextrose 5% In Plastic Container

84. Lidocaine Hydrochloride 0.2% And Dextrose 5% In Plastic Container

85. Lidocaine Hydrochloride 0.4% And Dextrose 5% In Plastic Container

86. Lidocaine Hydrochloride 0.8% And Dextrose 5% In Plastic Container

87. Nsc757420

88. S4667

89. (unlabeled)lidocaine-d6 Hydrochloride

90. Akos015889456

91. Cs-3888

92. Lp00669

93. Nsc 757420

94. Sb19119

95. Anhydrous Lidocaine Hydrochloride

96. Lidocaine Hydrochloride [who-dd]

97. Ncgc00094030-01

98. Ncgc00094030-02

99. Ncgc00094030-03

100. Ncgc00094030-04

101. Ncgc00094030-05

102. Ncgc00261354-01

103. Ac-11712

104. As-35171

105. Eu-0100669

106. Lignocaine Hydrochloride Pound>>lidocaine Hcl

107. A16132

108. D02086

109. L 5647

110. Lidocaine Hydrochloride Anhydrous [mart.]

111. A837924

112. Q-201304

113. Sr-01000000189-3

114. Sr-01000000189-9

115. Q27122094

116. 2-(diethylamino)-2',6'-acetoxylidide Monohydrochloride

117. 2-(diethylamino)-n-(2,6-dimethylphenyl)acetamide;hydrochloride

118. 2-(diethylamino)-n-(2,6-dimethylphenyl)ethanamide Hydrochloride

119. Acetamide, 2-(diethylamino)-n-(2,6-dimethylphenyl)-, Hydrochloride (1:1)

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₄H₂₃ClN₂O
Molecular Weight	270.80 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	270.1498911 g/mol
Monoisotopic Mass	270.1498911 g/mol
Topological Polar Surface Area	32.3 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	228
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 18
Drug Name	Laryng-o-jet kit
Drug Label	DESCRIPTIONLidocaine Hydrochloride Oral Topical Solution, USP (Viscous) 2% contains a local anesthetic agent and is administered topically. Lidocaine Hydrochloride Oral Topical Solution, USP (Viscous) 2% contains lidocaine hydrochloride, which is che...
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Solution
Route	Topical
Strength	4%
Market Status	Prescription
Company	Intl Medication

2 of 18
Drug Name	Lidocaine hydrochloride
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Jelly; Injectable; Solution
Route	Injection; Oral; Topical
Strength	0.5%; 1%; 20%; 2%; 4%
Market Status	Prescription
Company	Wockhardt; Igi Labs; Hospira; Roxane; Watson Labs; Intl Medication; Hi Tech Pharma; Vintage; Luitpold; Agila Speclts; Akorn

3 of 18
Drug Name	Lidocaine hydrochloride in plastic container
Drug Label	Each mL contains:Lidocaine Hydrochloride . . . . . . . . . . 20 mg (2%)Inactive ingredients: flavoring, methylparaben, propylparaben, sodium carboxymethylcellulose, and sodium saccharin in an aqueous solution.Lidocaine Viscous (Lidocaine Hydrochlorid...
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	0.5%; 1%; 2%
Market Status	Prescription
Company	Hospira; Fresenius Kabi Usa

4 of 18
Drug Name	Lidocaine hydrochloride preservative free
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	1%; 20%; 1.5%; 2%; 4%
Market Status	Prescription
Company	Hospira; Aurobindo Pharma; Intl Medication; Fresenius Kabi Usa; Agila Speclts

5 of 18
Drug Name	Lidocaine hydrochloride preservative free in plastic container
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	1%; 2%
Market Status	Prescription
Company	Hospira

6 of 18
Drug Name	Lidocaine hydrochloride viscous
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Solution
Route	Oral
Strength	2%
Market Status	Prescription
Company	Vintage

7 of 18
Drug Name	Lidocaine viscous
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Solution
Route	Oral
Strength	2%
Market Status	Prescription
Company	Roxane

8 of 18
Drug Name	Lta ii kit
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Solution
Route	Topical
Strength	4%
Market Status	Prescription
Company	Hospira

9 of 18
Drug Name	Xylocaine preservative free
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	1%; 20%; 2%; 4%
Market Status	Prescription
Company	Fresenius Kabi Usa

10 of 18
Drug Name	Laryng-o-jet kit
Drug Label	DESCRIPTIONLidocaine Hydrochloride Oral Topical Solution, USP (Viscous) 2% contains a local anesthetic agent and is administered topically. Lidocaine Hydrochloride Oral Topical Solution, USP (Viscous) 2% contains lidocaine hydrochloride, which is che...
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Solution
Route	Topical
Strength	4%
Market Status	Prescription
Company	Intl Medication

11 of 18
Drug Name	Lidocaine hydrochloride
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Jelly; Injectable; Solution
Route	Injection; Oral; Topical
Strength	0.5%; 1%; 20%; 2%; 4%
Market Status	Prescription
Company	Wockhardt; Igi Labs; Hospira; Roxane; Watson Labs; Intl Medication; Hi Tech Pharma; Vintage; Luitpold; Agila Speclts; Akorn

12 of 18
Drug Name	Lidocaine hydrochloride in plastic container
Drug Label	Each mL contains:Lidocaine Hydrochloride . . . . . . . . . . 20 mg (2%)Inactive ingredients: flavoring, methylparaben, propylparaben, sodium carboxymethylcellulose, and sodium saccharin in an aqueous solution.Lidocaine Viscous (Lidocaine Hydrochlorid...
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	0.5%; 1%; 2%
Market Status	Prescription
Company	Hospira; Fresenius Kabi Usa

13 of 18
Drug Name	Lidocaine hydrochloride preservative free
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	1%; 20%; 1.5%; 2%; 4%
Market Status	Prescription
Company	Hospira; Aurobindo Pharma; Intl Medication; Fresenius Kabi Usa; Agila Speclts

14 of 18
Drug Name	Lidocaine hydrochloride preservative free in plastic container
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	1%; 2%
Market Status	Prescription
Company	Hospira

15 of 18
Drug Name	Lidocaine hydrochloride viscous
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Solution
Route	Oral
Strength	2%
Market Status	Prescription
Company	Vintage

16 of 18
Drug Name	Lidocaine viscous
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Solution
Route	Oral
Strength	2%
Market Status	Prescription
Company	Roxane

17 of 18
Drug Name	Lta ii kit
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Solution
Route	Topical
Strength	4%
Market Status	Prescription
Company	Hospira

18 of 18
Drug Name	Xylocaine preservative free
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	1%; 20%; 2%; 4%
Market Status	Prescription
Company	Fresenius Kabi Usa

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Voltage-Gated Sodium Channel Blockers

A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS. (See all compounds classified as Voltage-Gated Sodium Channel Blockers.)

Anesthetics, Local

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Amides [CS]; Antiarrhythmic [EPC]; Local Anesthesia [PE]; Amide Local Anesthetic [EPC]

Lidocaine Hydrochloride

Lidocaine Hydrochloride

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

50 API Suppliers

13 USDMF

9 CEP/COS

3 JDMF

10 EU WC

13 KDMF

30 NDC API

37 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

4 Drugs in Development

FINISHED DOSAGE FORMULATIONS

409 FDF Dossiers

226 FDA Orange Book

67 Europe

63 Canada

17 South Africa

36 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

INJECTABLE;INJECTION - 4%

INJECTABLE;INJECTION - 1% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

INJECTABLE;INJECTION - 2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

INJECTABLE;INJECTION - 20% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

INJECTABLE;INJECTION - 4% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

INJECTABLE;INJECTION - 0.005MG/ML;0.5%

INJECTABLE;INJECTION - 0.005MG/ML;1%

INJECTABLE;INJECTION - 0.005MG/ML;1.5%

INJECTABLE;INJECTION - 0.005MG/ML;2%

INJECTABLE;INJECTION - 0.01MG/ML;1%

INJECTABLE;INJECTION - 0.01MG/ML;2%

INJECTABLE;INJECTION - 0.02MG/ML;2%

INJECTABLE;INJECTION - 0.5%

INJECTABLE;INJECTION - 1%

INJECTABLE;INJECTION - 1.5%

INJECTABLE;INJECTION - 2%

INJECTABLE;INJECTION - 1%

INJECTABLE;INJECTION - 2%

INJECTABLE;INJECTION - 1%

INJECTABLE;SPINAL - 5%

JELLY;TOPICAL - 2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

INJECTABLE;INJECTION - EQ 0.02MG BASE/ML;2%

INJECTABLE;INJECTION - EQ 0.01MG BASE/ML;2%

RELATED EXCIPIENT COMPANIES

6 Rochem International Inc

12 SPI Pharma

3 Seqens

13 DKSH

1 Jai Radhe Sales

1 PMC Isochem

1 Pharm-RX Chemical

1 Boai NKY Pharmaceuticals Ltd

8 Gangwal Healthcare

19 Nanjing Well Pharmaceutical

1 ACG Worldwide

22 Actylis

3 Aeon Procare

4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

43 BASF

1 Bioplus Life Sciences

1 BioSpectra

1 Clariant

17 Corel Pharma Chem

3 Doshion Polyscience

5 Finar

13 Gangwal Chemicals

4 Ideal Cures Pvt Ltd

2 Ingredion Pharma Solutions

18 Kerry

4 Kima Chemical

6 Lonza Capsugel

9 Lubrizol Life Science Health

9 Microlex e.U

3 Nanjing Bold Chemical

INJECTABLE;INJECTION - 1% Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

INJECTABLE;INJECTION - 2% Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

INJECTABLE;INJECTION - 20% Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

INJECTABLE;INJECTION - 4% Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

JELLY;TOPICAL - 2% Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons