Liothyronine

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ACTIVE PHARMA INGREDIENTS

13 API Suppliers, 6 USDMF, 3 CEP/COS, 1 JDMF, 3 EU WC, 1 KDMF, 8 NDC API, 5 Listed Suppliers, $ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

50 FDF Dossiers, 28 FDA Orange Book, 8 Europe, 4 Canada, 2 Australia, 3 South Africa, 5 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - EQ 0.005MG BASE, TABLET;ORAL - EQ 0.025MG BASE, TABLET;ORAL - EQ 0.05MG BASE, INJECTABLE;INJECTION - EQ 0.01MG BASE/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

2 Rochem International Inc, 17 SPI Pharma, 6 DKSH, 5 Faran Shimi Pharmaceutical, 9 Gangwal Healthcare, 2 Pfanstiehl, 4 ACG Worldwide, 2 Actylis, 1 Aeon Procare, 5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 5 BASF, 10 Corel Pharma Chem, 2 DFE Pharma, 6 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 3 Ingredion Pharma Solutions, 17 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 14 Microlex e.U, 1 Novo Excipients, 1 Pharmatrans-Sanaq, 5 Pluviaendo, 2 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 28 Roquette, 7 Seppic, 6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 9 Sigachi Industries, 2 The Dow Chemical Company, 3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

64 Fillers, Diluents & Binders, 44 Coating Systems & Additives, 32 Direct Compression, 23 Thickeners and Stabilizers, 21 Controlled & Modified Release, 20 Lubricants & Glidants, 19 Taste Masking, 16 Chewable & Orodispersible Aids, 15 Granulation, 15 Co-Processed Excipients, 10 Disintegrants & Superdisintegrants, 9 Empty Capsules, 9 Film Formers & Plasticizers, 8 Parenteral, 5 API Stability Enhancers, 4 Emulsifying Agents, 4 Vegetarian Capsules, 3 Solubilizers, 2 Coloring Agents, 2 Topical, 2 Rheology Modifiers

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1 DATA COMPILATION #PharmaFlow, 27 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 19 Finished Drug Prices

MARKET PLACE

17 APIs, 1 FDF Dossiers

REF. STANDARDS & IMPURITIES

3 EDQM, 1 USP, 2 Others

ANALYTICAL

1 BioAnalytical Methods

1 BioAnalytical Methods

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Also known as: 55-06-1, Cytomel, Triostat, 3,3',5-triiodo-l-thyronine sodium salt, Tertroxin, T3 sodium salt

Molecular Formula

C₁₅H₁₁I₃NNaO₄

Molecular Weight

672.95 g/mol

InChI Key

SBXXSUDPJJJJLC-YDALLXLXSA-M

FDA UNII

GCA9VV7D2N

A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate

2.1.2 InChI

InChI=1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1

2.1.3 InChI Key

SBXXSUDPJJJJLC-YDALLXLXSA-M

2.1.4 Canonical SMILES

C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)[O-])N)I)I)O.[Na+]

2.1.5 Isomeric SMILES

C1=CC(=C(C=C1OC2=C(C=C(C=C2I)C[C@@H](C(=O)[O-])N)I)I)O.[Na+]

2.2 Other Identifiers

2.2.1 UNII

GCA9VV7D2N

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 3,3',5-triiodothyronine

2. Cytomel

3. Liothyronine

4. T3 Thyroid Hormone

5. Thyroid Hormone, T3

6. Triiodothyronine

2.3.2 Depositor-Supplied Synonyms

1. 55-06-1

2. Cytomel

3. Triostat

4. 3,3',5-triiodo-l-thyronine Sodium Salt

5. Tertroxin

6. T3 Sodium Salt

7. Basoprocin

8. Ibiothyron

9. Cynomel

10. Triiodothyronine Sodium

11. L-triiodothyronine Sodium Salt

12. Cytobin

13. 3,3',5-triiodo-l-thyronine Sodium

14. 3,3',5-triiodothyronine Sodium Salt

15. Triiodothyronine Sodium Salt

16. L-tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, Monosodium Salt

17. Liotrix (t3)

18. Chebi:6484

19. Liothyronine (sodium)

20. Monosodium L-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)alanine

21. Gca9vv7d2n

22. Liothyronine (l- Isomer) Sodium

23. Rathyronine Sodium, (s)-

24. Cytomel Sodium

25. Lyothyronin

26. Nsc-80774

27. Nsc-758175

28. 3,3'',5-triiodo-l-thyronine Sodium Salt

29. Ro Thyronine

30. Sodium Triiodothyronine

31. Liothyronine Sodium Salt

32. Alanine, 3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)-, Monosodium Salt, L-

33. Sodium Liothyronine

34. Sodium T3

35. Sodium Triiodotironine

36. Sodium-l-triiodothyronine

37. Mls000028648

38. L-triiodothyronine Hydrochloride

39. Sodium (s)-2-amino-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoate

40. Rathyronine Hydrochloride, (s)-

41. Sodium Triiodothyronine, L-

42. Sodium 3,5,3'-triiodothyronine

43. Sodium L-3,5,3'-triiodothyronine

44. Smr000059206

45. Einecs 200-223-5

46. Unii-gca9vv7d2n

47. Mfcd00002594

48. Nsc 80774

49. Sodium 3,3',5-triiodo-l-thyronine

50. Sodium 3,5,3'-triiodo-l-thyronine

51. L-3,3',5-triiodothyronine Sodium Salt

52. Triostat (tn)

53. Cytomel (tn)

54. Liothyronine Sodium [usp:ban:jan]

55. Ibiot

56. L-tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, Sodium Salt (1:1)

57. Sodium;(2s)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate

58. O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-l-tyrosine Sodium Salt

59. T-3

60. Epitope Id:136777

61. T3 (liotrix)

62. T3, Na

63. Dsstox_cid_27505

64. Dsstox_rid_82385

65. Dsstox_gsid_47505

66. Schembl41654

67. 3,3',5-l-triiodothyronine

68. Spectrum1502047

69. Chembl1201119

70. Dtxsid8047505

71. Liothyronine Sodium [jan]

72. Nrp-409

73. Liothyronine Sodium (jp17/usp)

74. Hms1921h18

75. Hms2092b14

76. Liothyronine Sodium [vandf]

77. Act03263

78. Amy38143

79. Hy-a0070

80. Liothyronine Sodium [mart.]

81. Sodium L-3,3',5-triiodothyronine

82. Tox21_302514

83. Triiodothyronine Sodium, Levo

84. Ccg-39522

85. Liothyronine Sodium [usp-rs]

86. Liothyronine Sodium [who-dd]

87. Liotrix (t3) [orange Book]

88. S4217

89. Liothyronine Sodium Salt [mi]

90. Akos015918421

91. Akos032949712

92. Cs-3241

93. 3,3',5-triiodo-l-thyronine (sodium)

94. Cas-55-06-1

95. Liothyronine Sodium [green Book]

96. Liothyronine Sodium [orange Book]

97. Ncgc00256816-01

98. Ac-31934

99. As-13674

100. L-3,3',5-triiodothyronine, Sodium Salt

101. Liothyronine Sodium [ep Monograph]

102. Liothyronine Sodium [usp Monograph]

103. 3,5,3'-triiodo-l-thyronine Monosodium Salt

104. Sw219577-1

105. D01011

106. F20556

107. A830467

108. Q930170

109. Q-201881

110. 3,3',5-triiodo-l-thyronine Sodium Salt, >=95% (hplc)

111. Liothyronine Sodium, European Pharmacopoeia (ep) Reference Standard

112. O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-l-tyrosine, Monosodium Salt

113. 3,3',5-triiodo-l-thyronine Sodium Salt, Powder, Bioreagent, Suitable For Cell Culture

114. Liothyronine For Peak Identification, European Pharmacopoeia (ep) Reference Standard

115. Sodium (2s)-2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]propanoate

116. Sodium (2s)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate

117. 3,3',5-triiodo-l-thyronine Sodium Salt, Gamma-irradiated, Powder, Bioxtra, Suitable For Cell Culture

2.4 Create Date

2008-02-05

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₁₁I₃NNaO₄
Molecular Weight	672.95 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	672.7720 g/mol
Monoisotopic Mass	672.7720 g/mol
Topological Polar Surface Area	95.6 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	408
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Cytomel
PubMed Health	Liothyronine
Drug Classes	Diagnostic Agent, Thyroid Function, Thyroid Supplement
Drug Label	Thyroid hormone drugs are natural or synthetic preparations containing tetraiodothyronine (T4, levothyroxine) sodium or triiodothyronine (T3, liothyronine) sodium or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupli...
Active Ingredient	Liothyronine sodium
Dosage Form	Tablet
Route	Oral
Strength	eq 0.05mg base; eq 0.025mg base; eq 0.005mg base
Market Status	Prescription
Company	King Pharms R And D

2 of 6
Drug Name	Liothyronine sodium
Drug Label	Thyroid hormone drugs are natural or synthetic preparations containing tetraiodothyronine (T4, levothyroxine) sodium or triiodothyronine (T3, liothyronine) sodium or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupli...
Active Ingredient	Liothyronine sodium
Dosage Form	Tablet; Injectable
Route	Injection; Oral
Strength	eq 0.05mg base; eq 0.025mg base; eq 0.005mg base; eq 0.01mg base/ml
Market Status	Prescription
Company	X Gen Pharms; Coastal Pharms; Sigmapharm Labs; Mylan

3 of 6
Drug Name	Triostat
PubMed Health	Liothyronine
Drug Classes	Diagnostic Agent, Thyroid Function, Thyroid Supplement
Active Ingredient	Liothyronine sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 0.01mg base/ml
Market Status	Prescription
Company	Par Sterile Products

4 of 6
Drug Name	Cytomel
PubMed Health	Liothyronine
Drug Classes	Diagnostic Agent, Thyroid Function, Thyroid Supplement
Drug Label	Thyroid hormone drugs are natural or synthetic preparations containing tetraiodothyronine (T4, levothyroxine) sodium or triiodothyronine (T3, liothyronine) sodium or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupli...
Active Ingredient	Liothyronine sodium
Dosage Form	Tablet
Route	Oral
Strength	eq 0.05mg base; eq 0.025mg base; eq 0.005mg base
Market Status	Prescription
Company	King Pharms R And D

5 of 6
Drug Name	Liothyronine sodium
Drug Label	Thyroid hormone drugs are natural or synthetic preparations containing tetraiodothyronine (T4, levothyroxine) sodium or triiodothyronine (T3, liothyronine) sodium or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupli...
Active Ingredient	Liothyronine sodium
Dosage Form	Tablet; Injectable
Route	Injection; Oral
Strength	eq 0.05mg base; eq 0.025mg base; eq 0.005mg base; eq 0.01mg base/ml
Market Status	Prescription
Company	X Gen Pharms; Coastal Pharms; Sigmapharm Labs; Mylan

6 of 6
Drug Name	Triostat
PubMed Health	Liothyronine
Drug Classes	Diagnostic Agent, Thyroid Function, Thyroid Supplement
Active Ingredient	Liothyronine sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 0.01mg base/ml
Market Status	Prescription
Company	Par Sterile Products

5 Pharmacology and Biochemistry

5.1 FDA Pharmacological Classification

5.1.1 Pharmacological Classes

l-Triiodothyronine [EPC]; Triiodothyronine [CS]

5.2 ATC Code

H - Systemic hormonal preparations, excl. sex hormones and insulins

H03 - Thyroid therapy

H03A - Thyroid preparations

H03AA - Thyroid hormones

H03AA02 - Liothyronine sodium

Liothyronine

Liothyronine

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ACTIVE PHARMA INGREDIENTS

13 API Suppliers

6 USDMF

3 CEP/COS

1 JDMF

3 EU WC

1 KDMF

8 NDC API

5 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

50 FDF Dossiers

28 FDA Orange Book

8 Europe

4 Canada

2 Australia

3 South Africa

5 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - EQ 0.005MG BASE

TABLET;ORAL - EQ 0.025MG BASE

TABLET;ORAL - EQ 0.05MG BASE

INJECTABLE;INJECTION - EQ 0.01MG BASE/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

2 Rochem International Inc

17 SPI Pharma

6 DKSH

5 Faran Shimi Pharmaceutical

9 Gangwal Healthcare

2 Pfanstiehl

4 ACG Worldwide

2 Actylis

1 Aeon Procare

5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

5 BASF

10 Corel Pharma Chem

2 DFE Pharma

6 Gangwal Chemicals

5 Ideal Cures Pvt Ltd

3 Ingredion Pharma Solutions

17 Kerry

3 Kima Chemical

6 Lonza Capsugel

14 Microlex e.U

1 Novo Excipients

1 Pharmatrans-Sanaq

5 Pluviaendo

2 Prachin Chemical

1 Qianhao Chemical (Hebei) Co., Ltd

2 Qualicaps

28 Roquette

7 Seppic

6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Shijiazhuang Huaxu Pharmaceutical

9 Sigachi Industries

2 The Dow Chemical Company

3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

64 Fillers, Diluents & Binders

44 Coating Systems & Additives

32 Direct Compression

23 Thickeners and Stabilizers

21 Controlled & Modified Release

20 Lubricants & Glidants

19 Taste Masking

16 Chewable & Orodispersible Aids

15 Granulation

15 Co-Processed Excipients

10 Disintegrants & Superdisintegrants

9 Empty Capsules

9 Film Formers & Plasticizers

8 Parenteral

INJECTABLE;INJECTION - EQ 0.01MG BASE/ML Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons