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2D Structure
Also known as: Lisuride hydrogen maleate, 19875-60-6, Lisuride maleate [jan], Lysenyl hydrogen maleate, Uv1635n8xw, R(+)-lisuride hydrogen maleate
Molecular Formula
C24H30N4O5
Molecular Weight
454.5  g/mol
InChI Key
CVQFAMQDTWVJSV-BAXNFHPCSA-N
FDA UNII
UV1635N8XW

An ergot derivative that acts as an agonist at dopamine D2 receptors (DOPAMINE AGONISTS). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (SEROTONIN RECEPTOR AGONISTS).
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[(6aR,9S)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]-1,1-diethylurea;(Z)-but-2-enedioic acid
2.1.2 InChI
InChI=1S/C20H26N4O.C4H4O4/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14;5-3(6)1-2-4(7)8/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,18+;/m0./s1
2.1.3 InChI Key
CVQFAMQDTWVJSV-BAXNFHPCSA-N
2.1.4 Canonical SMILES
CCN(CC)C(=O)NC1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C.C(=CC(=O)O)C(=O)O
2.1.5 Isomeric SMILES
CCN(CC)C(=O)N[C@@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)C.C(=C\C(=O)O)\C(=O)O
2.2 Other Identifiers
2.2.1 UNII
UV1635N8XW
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Arolac

2. Carbamide, Methylergol

3. Cuvalit

4. Dopergin

5. Dopergine

6. Hydrochloride, Lisuride

7. Hydrogen Maleate, Lysuride

8. Lisuride

9. Lisuride Hydrochloride

10. Lisuride Maleate (1:1)

11. Lisuride Maleate, (8beta)-isomer

12. Lisuride Mesylate

13. Lisuride Phosphate (1:1)

14. Lisuride, (8alpha)-(+-)-isomer

15. Lysenyl

16. Lysurid

17. Lysuride Hydrogen Maleate

18. Maleate, Lisuride

19. Mesylate, Lisuride

20. Methylergol Carbamide

21. Revanil

2.3.2 Depositor-Supplied Synonyms

1. Lisuride Hydrogen Maleate

2. 19875-60-6

3. Lisuride Maleate [jan]

4. Lysenyl Hydrogen Maleate

5. Uv1635n8xw

6. R(+)-lisuride Hydrogen Maleate

7. Lisuride (maleate)

8. Lysuride Maleate

9. Cuvalit

10. Lysenyl

11. Lisuride Maleate (jan)

12. Lysenyl Bimaleate

13. 3-(9,10-didehydro-6-methylergolin-8-alpha-yl)-1,1-diethylurea Maleate (1:1)

14. 3-(9,10-didehydro-6-methylergolin-8-yl)-1,1-diethylurea Hydrogen Maleate

15. Urea, N'-((8-alpha)-9,10-didehydro-6-methylergolin-8-yl)-n,n-diethyl-, (z)-2-butenedioate

16. Chebi:31776

17. Urea, N'-[(8alpha)-9,10-didehydro-6-methylergolin-8-yl]-n,n-diethyl-, (2z)-2-butenedioate (1:1)

18. Einecs 243-387-3

19. Unii-uv1635n8xw

20. 1-((5r,8s)-6-methyl-9,10-didehydro-8-ergolinyl)-3,3-diethylurea Hydrogen Maleate

21. Lisuride Maleate [mi]

22. Schembl364392

23. Chembl1257128

24. Lisuride Maleate [mart.]

25. Lisuride Maleate [who-dd]

26. Dtxsid501017378

27. Akos025142010

28. Urea, 3-(9,10-didehydro-6-methylergolin-8-alpha-yl)-1,1-diethyl-, Maleate (1:1)

29. Hy-110080

30. Cs-0032924

31. D01462

32. Sr-01000075387

33. Sr-01000075387-1

34. Q27114683

35. N'-[(8?)-9,10-didehydro-6-methylergolin-8-yl]-n,n-diethylurea Maleate

36. 3-(9,10-didehydro-6-methylergolin-8.alpha.-yl)-1,1-diethylurea Maleate (1:1)

37. R(+)-n'-[(8alpha)-9,10-didehydro-6-methylergolin-8-yl]-n,n,-diethylurea Hydrogen Maleate

2.4 Create Date
2005-10-11
3 Chemical and Physical Properties
Molecular Weight 454.5 g/mol
Molecular Formula C24H30N4O5
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass454.22162007 g/mol
Monoisotopic Mass454.22162007 g/mol
Topological Polar Surface Area126 Ų
Heavy Atom Count33
Formal Charge0
Complexity663
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antiparkinson Agents

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)


Serotonin Receptor Agonists

Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS. (See all compounds classified as Serotonin Receptor Agonists.)


Dopamine Agonists

Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)