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    Lisuride Maleate

    ACTIVE PHARMA INGREDIENTS

    MARKET PLACE

    PharmaCompass
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    2D Structure
    Also known as: Lisuride hydrogen maleate, 19875-60-6, Lisuride maleate [jan], Lysenyl hydrogen maleate, Uv1635n8xw, R(+)-lisuride hydrogen maleate
    Molecular Formula
    C24H30N4O5
    Molecular Weight
    454.5  g/mol
    InChI Key
    CVQFAMQDTWVJSV-BAXNFHPCSA-N
    FDA UNII
    UV1635N8XW
    An ergot derivative that acts as an agonist at dopamine D2 receptors (DOPAMINE AGONISTS). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (SEROTONIN RECEPTOR AGONISTS).
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-[(6aR,9S)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]-1,1-diethylurea;(Z)-but-2-enedioic acid
    2.1.2 InChI
    InChI=1S/C20H26N4O.C4H4O4/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14;5-3(6)1-2-4(7)8/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,18+;/m0./s1
    2.1.3 InChI Key
    CVQFAMQDTWVJSV-BAXNFHPCSA-N
    2.1.4 Canonical SMILES
    CCN(CC)C(=O)NC1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C.C(=CC(=O)O)C(=O)O
    2.1.5 Isomeric SMILES
    CCN(CC)C(=O)N[C@@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)C.C(=C\C(=O)O)\C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    UV1635N8XW
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Arolac

    2. Carbamide, Methylergol

    3. Cuvalit

    4. Dopergin

    5. Dopergine

    6. Hydrochloride, Lisuride

    7. Hydrogen Maleate, Lysuride

    8. Lisuride

    9. Lisuride Hydrochloride

    10. Lisuride Maleate (1:1)

    11. Lisuride Maleate, (8beta)-isomer

    12. Lisuride Mesylate

    13. Lisuride Phosphate (1:1)

    14. Lisuride, (8alpha)-(+-)-isomer

    15. Lysenyl

    16. Lysurid

    17. Lysuride Hydrogen Maleate

    18. Maleate, Lisuride

    19. Mesylate, Lisuride

    20. Methylergol Carbamide

    21. Revanil

    2.3.2 Depositor-Supplied Synonyms

    1. Lisuride Hydrogen Maleate

    2. 19875-60-6

    3. Lisuride Maleate [jan]

    4. Lysenyl Hydrogen Maleate

    5. Uv1635n8xw

    6. R(+)-lisuride Hydrogen Maleate

    7. Lisuride (maleate)

    8. Lysuride Maleate

    9. Cuvalit

    10. Lysenyl

    11. Lisuride Maleate (jan)

    12. Lysenyl Bimaleate

    13. 3-(9,10-didehydro-6-methylergolin-8-alpha-yl)-1,1-diethylurea Maleate (1:1)

    14. 3-(9,10-didehydro-6-methylergolin-8-yl)-1,1-diethylurea Hydrogen Maleate

    15. Urea, N'-((8-alpha)-9,10-didehydro-6-methylergolin-8-yl)-n,n-diethyl-, (z)-2-butenedioate

    16. Chebi:31776

    17. Urea, N'-[(8alpha)-9,10-didehydro-6-methylergolin-8-yl]-n,n-diethyl-, (2z)-2-butenedioate (1:1)

    18. Einecs 243-387-3

    19. Unii-uv1635n8xw

    20. 1-((5r,8s)-6-methyl-9,10-didehydro-8-ergolinyl)-3,3-diethylurea Hydrogen Maleate

    21. Lisuride Maleate [mi]

    22. Schembl364392

    23. Chembl1257128

    24. Lisuride Maleate [mart.]

    25. Lisuride Maleate [who-dd]

    26. Dtxsid501017378

    27. Akos025142010

    28. Urea, 3-(9,10-didehydro-6-methylergolin-8-alpha-yl)-1,1-diethyl-, Maleate (1:1)

    29. Hy-110080

    30. Cs-0032924

    31. D01462

    32. Sr-01000075387

    33. Sr-01000075387-1

    34. Q27114683

    35. N'-[(8?)-9,10-didehydro-6-methylergolin-8-yl]-n,n-diethylurea Maleate

    36. 3-(9,10-didehydro-6-methylergolin-8.alpha.-yl)-1,1-diethylurea Maleate (1:1)

    37. R(+)-n'-[(8alpha)-9,10-didehydro-6-methylergolin-8-yl]-n,n,-diethylurea Hydrogen Maleate

    2.4 Create Date
    2005-10-11
    3 Chemical and Physical Properties
    Molecular Weight 454.5 g/mol
    Molecular Formula C24H30N4O5
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count5
    Exact Mass454.22162007 g/mol
    Monoisotopic Mass454.22162007 g/mol
    Topological Polar Surface Area126 Ų
    Heavy Atom Count33
    Formal Charge0
    Complexity663
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antiparkinson Agents

    Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)

    Serotonin Receptor Agonists

    Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS. (See all compounds classified as Serotonin Receptor Agonists.)

    Dopamine Agonists

    Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)