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    Lomefloxacin

    ACTIVE PHARMA INGREDIENTS

    INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

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    PharmaCompass
    $ API Ref.Price (USD/KG) : 374Xls

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    2D Structure
    Also known as: 98079-52-8, Lomefloxacin hcl, Maxaquin, Okacyn, Ny-198, Bareon
    Molecular Formula
    C17H20ClF2N3O3
    Molecular Weight
    387.8  g/mol
    InChI Key
    KXEBLAPZMOQCKO-UHFFFAOYSA-N
    FDA UNII
    9VC7S3ZXXB
    Lomefloxacin Hydrochloride is the hydrochloride salt form of lomefloxacin, a synthetic broad-spectrum fluoroquinolone with antibacterial activity. Lomefloxacin hydrochloride inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inhibition leads to a decrease in DNA synthesis during bacterial replication, resulting in cell growth inhibition and eventually cell lysis.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid;hydrochloride
    2.1.2 InChI
    InChI=1S/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H
    2.1.3 InChI Key
    KXEBLAPZMOQCKO-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    9VC7S3ZXXB
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid

    2. Dcalogiflox

    3. Logiflox

    4. Lomefloxacin

    5. Lomenfloxacin

    6. Maxaquin

    7. Ny 198

    8. Ny-198

    9. Ocacin

    10. Okacin

    11. Okacyn

    12. Sc 4711

    13. Sc-4711

    2.3.2 Depositor-Supplied Synonyms

    1. 98079-52-8

    2. Lomefloxacin Hcl

    3. Maxaquin

    4. Okacyn

    5. Ny-198

    6. Bareon

    7. Uniquin

    8. Sc-47111

    9. Lomefloxacin (hydrochloride)

    10. Lomefloxacin Monohydrochloride

    11. 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid Hydrochloride

    12. 9vc7s3zxxb

    13. Nsc-758168

    14. 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic Acid;hydrochloride

    15. Chebi:6518

    16. Lomefloxacin (as Hydrochloride)

    17. Lomefloxacin Hydrochloride (maxaquin)

    18. Mazaquin

    19. Dsstox_cid_25527

    20. Dsstox_rid_80931

    21. Dsstox_gsid_45527

    22. Logiflox

    23. Okacin

    24. Ny 198

    25. (+-)-1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Monohydrochloride

    26. 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Hydrochloride

    27. Ccris 2581

    28. Sr-01000075959

    29. Unii-9vc7s3zxxb

    30. Mfcd00214312

    31. Lomefloxacin Hydrochloride [usan:jan]

    32. Lomebact

    33. Maxaquine

    34. Maxaquin (tn)

    35. Prestwick_581

    36. 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid

    37. Ncgc00016964-01

    38. Ncgc00016964-02

    39. Lomefloxacin, Hydrochloride

    40. Cas-98079-52-8

    41. Chembl1728

    42. Lomefloxacin Hcl (maxaquin)

    43. Schembl42051

    44. (+-)-1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid, Monohydrochloride

    45. Spectrum1502037

    46. Dtxsid2045527

    47. Hms1568p17

    48. Hms1921f20

    49. Pharmakon1600-01502037

    50. Bcp12636

    51. Hy-b0455

    52. Tox21_110716

    53. Tox21_113154

    54. Tox21_500678

    55. Ccg-39698

    56. Nsc758168

    57. S2539

    58. Akos015895388

    59. Tox21_110716_1

    60. Ks-1238

    61. Lomefloxacin Hydrochloride (jan/usan)

    62. Lp00678

    63. Nsc 758168

    64. Lomefloxacin Hydrochloride [jan]

    65. Lomefloxacin Hydrochloride [usan]

    66. Ncgc00015603-08

    67. Ncgc00094038-01

    68. Ncgc00094038-02

    69. Ncgc00094038-03

    70. Ncgc00261363-01

    71. 3-quinolinecarboxylic Acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-, Monohydrochloride

    72. 3-quinolinecarboxylic Acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, Monohydrochloride, (+-)-

    73. Ac-32592

    74. Lomefloxacin Hydrochloride [mart.]

    75. Lomefloxacin Hydrochloride [vandf]

    76. Lomefloxacin Hydrochloride [who-dd]

    77. Lomefloxacin Monohydrochloride [mi]

    78. Db-057707

    79. Eu-0100678

    80. Ft-0630997

    81. L0216

    82. C08053

    83. D00873

    84. L 2906

    85. L-6500

    86. Lomefloxacin Hydrochloride [orange Book]

    87. O11839

    88. 079l528

    89. A845801

    90. A845802

    91. A858587

    92. Tert-butyl4-fluoro-2-formylphenylcarbamate

    93. Sr-01000075959-1

    94. Sr-01000075959-5

    95. Lomefloxacin Hydrochloride 100 Microg/ml In Methanol

    96. Q27107226

    97. Lomefloxacin Monohydrochloride, Antibiotic For Culture Media Use Only

    98. (+/-)-1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid, Monohydrochloride

    99. 1-ethyl-6,8-bis(fluoranyl)-7-(3-methylpiperazin-1-yl)-4-oxidanylidene-quinoline-3-carboxylic Acid Hydrochloride

    100. 1-ethyl-6,8-difluoro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Hydrochloride

    101. 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic Acid Hydrochloride;lomefloxacin

    102. 3-quinolinecarboxylic Acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, Monohydrochloride, (+/-)-

    103. 3-quinolinecarboxylic Acid,1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-,monohydrochloride

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 387.8 g/mol
    Molecular Formula C17H20ClF2N3O3
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count3
    Exact Mass387.1161255 g/mol
    Monoisotopic Mass387.1161255 g/mol
    Topological Polar Surface Area72.9 Ų
    Heavy Atom Count26
    Formal Charge0
    Complexity586
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

    Topoisomerase II Inhibitors

    Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)