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    Lomitapide

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

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    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: 202914-84-9, Bms 201038-04, Lomitapide (mesylate), Aegr-733 mesylate, Bms-201038-04, Lomitapide mesilate
    Molecular Formula
    C40H41F6N3O5S
    Molecular Weight
    789.8  g/mol
    InChI Key
    QKVKOFVWUHNEBX-UHFFFAOYSA-N
    FDA UNII
    X4S83CP54E
    Lomitapide Mesylate is a methanesulfonic acid form of lomitapide, a small molecule inhibitor of microsomal triglyceride transfer protein.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    methanesulfonic acid;N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide
    2.1.2 InChI
    InChI=1S/C39H37F6N3O2.CH4O3S/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45;1-5(2,3)4/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49);1H3,(H,2,3,4)
    2.1.3 InChI Key
    QKVKOFVWUHNEBX-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CS(=O)(=O)O.C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F
    2.2 Other Identifiers
    2.2.1 UNII
    X4S83CP54E
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. 202914-84-9

    2. Bms 201038-04

    3. Lomitapide (mesylate)

    4. Aegr-733 Mesylate

    5. Bms-201038-04

    6. Lomitapide Mesilate

    7. Lomitapide Mesylate [usan]

    8. Aegr-733 Mesilate

    9. X4s83cp54e

    10. Chebi:72299

    11. 202914-84-9 (mesylate)

    12. N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)biphenyl-2-ylcarboxamido)piperidin-1-yl)butyl)-9h-fluorene-9-carboxamide Methanesulfonate

    13. Lomitapide Mesilate (jan)

    14. Lomitapide Mesylate (usan)

    15. N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamido)piperidin-1-yl)butyl)-9h-fluorene-9-carboxamide Methanesulfonate

    16. Lomitapide Mesilate [jan]

    17. 9h-fluorene-9-carboxamide, N-(2,2,2-trifluoroethyl)-9-(4-(4-(((4'-(trifluoromethyl)(1,1'-biphenyl)-2-yl)carbonyl)amino)-1-piperidinyl)butyl)-, Methanesulfonate

    18. Methanesulfonic Acid;n-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide

    19. Unii-x4s83cp54e

    20. Juxtapid (tn)

    21. N-(2,2,2-trifluoroethyl)-9-(4-(4-(((4'-(trifluoromethyl)biphenyl-2-yl)carbonyl)amino)piperidin-1-yl)butyl)-9h-fluorene-9-carboxamide Methanesulfonate

    22. N-(2,2,2-trifluoroethyl)-9-{4-(4-({(4'-(trifluoromethyl)biphenyl-2-yl)carbonyl}amino)piperidin-1-yl)butyl}-9h-fluorene-9-carboxamide Methanesulfonate

    23. N-(2,2,2-trifluoroethyl)-9-{4-[4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)piperidin-1-yl]butyl}-9h-fluorene-9-carboxamide Methanesulfonate

    24. Lojuxta (tn)

    25. Lomitapide Monomesylate

    26. Lomitapide Methanesulfonate

    27. Bms-201038 Mesylate

    28. Schembl2731380

    29. Chembl2105662

    30. Dtxsid60174170

    31. Ex-a502

    32. Bms-201038ma

    33. Glxc-25701

    34. Amy38734

    35. Bcp10696

    36. Cia91484

    37. Lomitapide Mesilate [who-dd]

    38. Mfcd19443682

    39. S7633

    40. Akos025149431

    41. Ccg-270481

    42. Cs-3424

    43. Lomitapide Mesylate [orange Book]

    44. Ac-33863

    45. As-56518

    46. Da-33433

    47. Hy-14668

    48. Ft-0700260

    49. D09638

    50. J-690260

    51. Q27139887

    52. 1-(4-{9-[(2,2,2-trifluoroethyl)carbamoyl]-9h-fluoren-9-yl}butyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)piperidinium Methanesulfonate

    53. 2059395-52-5

    54. 9h-fluorene-9-carboxamide, N-(2,2,2-trifluoroethyl)-9-(4-(4-(((4'-(trifluoromethyl)(1,1'-biphenyl)-2-yl)carbonyl)amino)-1-piperidinyl)butyl)-, Methanesulphonate

    55. Aegr-733 Mesylate;bms-201038 Mesylate;aegr733 Mesylate;bms201038 Mesylate;aegr 733 Mesylate;bms 201038 Mesylate

    56. N-(2,2,2-trifluoroethyl)-9-(4-(4-(((4'-(trifluoromethyl)biphenyl-2-yl)carbonyl)amino)piperidin-1-yl)butyl)-9h-fluorene-9-carboxamide Methanesulphonate

    57. N-(2,2,2-trifluoroethyl)-9-[4-(4-{2-[4-(trifluoromethyl)phenyl]benzamido}piperidin-1-yl)butyl]-9h-fluorene-9-carboxamide; Methanesulfonic Acid

    2.4 Create Date
    2006-10-26
    3 Chemical and Physical Properties
    Molecular Weight 789.8 g/mol
    Molecular Formula C40H41F6N3O5S
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count12
    Rotatable Bond Count10
    Exact Mass789.26711156 g/mol
    Monoisotopic Mass789.26711156 g/mol
    Topological Polar Surface Area124 Ų
    Heavy Atom Count55
    Formal Charge0
    Complexity1200
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameJuxtapid
    PubMed HealthLomitapide (By mouth)
    Drug ClassesAntihyperlipidemic
    Drug LabelJUXTAPID capsules contain lomitapide mesylate, a synthetic lipid-lowering agent for oral administration.The chemical name of lomitapide mesylate is N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-pi
    Active IngredientLomitapide mesylate
    Dosage FormCapsule
    RouteOral
    Strengtheq 5mg base; eq 20mg base; eq 10mg base
    Market StatusPrescription
    CompanyAegerion

    2 of 2  
    Drug NameJuxtapid
    PubMed HealthLomitapide (By mouth)
    Drug ClassesAntihyperlipidemic
    Drug LabelJUXTAPID capsules contain lomitapide mesylate, a synthetic lipid-lowering agent for oral administration.The chemical name of lomitapide mesylate is N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-pi
    Active IngredientLomitapide mesylate
    Dosage FormCapsule
    RouteOral
    Strengtheq 5mg base; eq 20mg base; eq 10mg base
    Market StatusPrescription
    CompanyAegerion

    5 Pharmacology and Biochemistry
    5.1 FDA Pharmacological Classification
    5.1.1 Pharmacological Classes
    Microsomal Triglyceride Transfer Protein Inhibitor [EPC]; Microsomal Triglyceride Transfer Protein Inhibitors [MoA]; P-Glycoprotein Inhibitors [MoA]; Cytochrome P450 3A4 Inhibitors [MoA]