1. Methyllorazepam
1. Methyllorazepam
2. N-methyllorazepam
3. Noctamid
4. Loramet
5. 848-75-9
6. Lormetazepamum
7. Chlorotemazepam
8. Ergocalm
9. Noctamide
10. Wy-4082
11. Loramet (tn)
12. 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2h-1,4-benzodiazepin-2-one
13. Ro 5-5516
14. Wy 4082
15. 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2h-1,4-benzodiazepin-2-one
16. 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1h-1,4-benzodiazepin-2-one
17. 2h-1,4-benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-
18. 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3h-1,4-benzodiazepin-2-one
19. Chembl22097
20. Gu56c842za
21. Chebi:52993
22. 2h-1,4-benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(o-chlorophenyl)-3-hydroxy-1-methyl-
23. 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one
24. Lormetazepamum [inn-latin]
25. (rs)-lormetazepam
26. (+/-)-lormetazepam
27. Lormetazepam [usan:inn:ban:jan]
28. Einecs 212-700-5
29. Brn 0759821
30. Unii-gu56c842za
31. Loretam
32. Dea No. 2774
33. ()-lorazepam
34. (+-)-lorazepam
35. Lormetazepam [mi]
36. Lormetazepam [inn]
37. Lormetazepam [jan]
38. Lormetazepam [usan]
39. Schembl43267
40. Lormetazepam [mart.]
41. Lormetazepam [who-dd]
42. Gtpl7553
43. Lormetazepam (jan/usan/inn)
44. Dtxsid40862442
45. Lormetazepam 0.1 Mg/ml In Methanol
46. Lormetazepam 1.0 Mg/ml In Methanol
47. Ortho-chloro-3-hydroxydiazepam
48. Db13872
49. Zk-65997
50. D01657
51. Q186257
52. 7-chloro-1,3-dihydro-5-(o-chlorophenyl)-3-hydroxy-1-methyl-2h-1,4-benzodiazepin-2-one
53. 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one #
54. Lormetazepam Solution, 1.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material
| Molecular Weight | 335.2 g/mol |
|---|---|
| Molecular Formula | C16H12Cl2N2O2 |
| XLogP3 | 2.4 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 334.0275830 g/mol |
| Monoisotopic Mass | 334.0275830 g/mol |
| Topological Polar Surface Area | 52.9 Ų |
| Heavy Atom Count | 22 |
| Formal Charge | 0 |
| Complexity | 471 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
For the treatment of short-term insomnia
Lormetazepam is a benzodiazepine which reduces central nervous system (CNS) activity. It produces anxiolytic, muscle relaxant, sedative and hypnotic effects. Because it is a short-acting benzodiapine, it does not produce significant sedation after waking.
Hypnotics and Sedatives
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)
N05CD06
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
N - Nervous system
N05 - Psycholeptics
N05C - Hypnotics and sedatives
N05CD - Benzodiazepine derivatives
N05CD06 - Lormetazepam
Metabolised to an inactive metabolite via glucuronide conjugation
The terminal phase half life is 11 h.
Lormetazepam, as a benzodiazepine, binds to the regulatory site between the and subunits of -aminobutryic acid (GABA) A receptors with 2 and 1, 2, 3, or 5 subunits. This facilitates the opening of the chloride channel allowing chloride ions to flow into the neuron resulting in hyperpolarization. Hyperpolarized neurons require greater simulation to reach their action potential threshold. The general inhibitory effect on neuronal depolarization produces the effects of lormetazepam.
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