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    Loxapine Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    PharmaCompass
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    2D Structure
    Also known as: Loxapine hcl, Loxitane c, Loxitane im, 54810-23-0, Loxapine (hydrochloride), 376myl4mal
    Molecular Formula
    C18H19Cl2N3O
    Molecular Weight
    364.3  g/mol
    InChI Key
    JSXBVMKACNEMKY-UHFFFAOYSA-N
    FDA UNII
    376MYL4MAL
    An antipsychotic agent used in schizophrenia.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine;hydrochloride
    2.1.2 InChI
    InChI=1S/C18H18ClN3O.ClH/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18;/h2-7,12H,8-11H2,1H3;1H
    2.1.3 InChI Key
    JSXBVMKACNEMKY-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    376MYL4MAL
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-chloro-11-(4-methyl-1-piperazinyl)-dibenz(b,f)(1,4)oxazepine

    2. Cl 71,563

    3. Cl-71,563

    4. Cl71,563

    5. Cloxazepine

    6. Hydrochloride, Loxapine

    7. Loxapine

    8. Loxapine Monohydrochloride

    9. Loxapine Succinate

    10. Loxapinsuccinate

    11. Loxipine Maleate

    12. Loxipine Succinate

    13. Loxitane

    14. Maleate, Loxipine

    15. Oxilapine

    16. Succinate, Loxapine

    2.3.2 Depositor-Supplied Synonyms

    1. Loxapine Hcl

    2. Loxitane C

    3. Loxitane Im

    4. 54810-23-0

    5. Loxapine (hydrochloride)

    6. 376myl4mal

    7. Desconex (tn)

    8. Loxapine Monohydrochloride

    9. Unii-376myl4mal

    10. 2-chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine Monohydrochloride

    11. Schembl41625

    12. Chembl1201060

    13. Dtxsid70203304

    14. Hy-17390b

    15. Loxapine Hydrochloride [vandf]

    16. Loxapine Hydrochloride [mart.]

    17. Loxapine Hydrochloride [who-dd]

    18. Dibenz(b,f)(1,4)oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-, Monohydrochloride

    19. Loxapine Hydrochloride [orange Book]

    20. Cs-0031021

    21. Ft-0670868

    22. D08148

    23. Q27256644

    24. 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine;hydrochloride

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 364.3 g/mol
    Molecular Formula C18H19Cl2N3O
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count1
    Exact Mass363.0905176 g/mol
    Monoisotopic Mass363.0905176 g/mol
    Topological Polar Surface Area28.1 Ų
    Heavy Atom Count24
    Formal Charge0
    Complexity450
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

    Dopamine Antagonists

    Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)