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    Loxoprofen

    ACTIVE PHARMA INGREDIENTS

    INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

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    $ API Ref.Price (USD/KG) : 195Xls

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    2D Structure
    Also known as: 226721-96-6, Loxonin, Oxeno, Lobu, Loxoprofen sodium, Loxoprofen sodium hydrate
    Molecular Formula
    C15H21NaO5
    Molecular Weight
    304.31  g/mol
    InChI Key
    BAZQYVYVKYOAGO-UHFFFAOYSA-M
    FDA UNII
    Z2DR42L11Y
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;2-[4-[(2-oxocyclopentyl)methyl]phenyl]propanoate;dihydrate
    2.1.2 InChI
    InChI=1S/C15H18O3.Na.2H2O/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16;;;/h5-8,10,13H,2-4,9H2,1H3,(H,17,18);;2*1H2/q;+1;;/p-1
    2.1.3 InChI Key
    BAZQYVYVKYOAGO-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    CC(C1=CC=C(C=C1)CC2CCCC2=O)C(=O)[O-].O.O.[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    Z2DR42L11Y
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 156-s

    2. 2-(4-((2-oxocyclopentyl)methyl)phenyl)propionic Acid

    3. 2-ocppp

    4. Cs 600

    5. Cs-600

    6. Loxoprofen

    7. Loxoprofen Alcohol

    8. Loxoprofen Sodium, (r*,s*)-isomer

    9. Sodium 2-(4-(2-oxocyclopentylmethyl)phenyl)propionate Dihydrate

    10. Sodium Loxoprofen

    2.3.2 Depositor-Supplied Synonyms

    1. 226721-96-6

    2. Loxonin

    3. Oxeno

    4. Lobu

    5. Loxoprofen Sodium

    6. Loxoprofen Sodium Hydrate

    7. Loxoprofen Sodium Salt Dihydrate

    8. 80382-23-6

    9. Loxoprofen Sodium [mart.]

    10. Loxoprofen Sodium Hydrate [jp]

    11. Loxoprofen (monosodium)

    12. Lobu; Loxonin;cs 600

    13. Sodium;2-[4-[(2-oxocyclopentyl)methyl]phenyl]propanoate;dihydrate

    14. Z2dr42l11y

    15. Monosodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate Dihydrate

    16. Sodium 2-(4-(2-oxocyclopentylmethyl)phenyl)propionate Dihydrate

    17. Alpha-methyl-4-((2-oxocyclopentyl)methyl)benzeneacetate Sodium Salt Dihydrate

    18. Unii-z2dr42l11y

    19. Lorfenamin (tn)

    20. Loxonin (tn)

    21. Loxoprofensodiumdihydrate

    22. Chebi:31786

    23. Dtxsid601001203

    24. Loxoprofen Sodium Hydrate (jp17)

    25. Bja72196

    26. Ac-555

    27. Mfcd01745788

    28. Akos015894920

    29. Akos015963323

    30. Benzeneacetic Acid, Alpha-methyl-4-((2-oxocyclopentyl)methyl)-, Sodium Salt, Hydrate (1:1:2)

    31. (r)-2-chloro-3-methylbutyricacid

    32. As-82727

    33. Loxoprofen Sodium Dihydrate [who-dd]

    34. D01709

    35. Q27114685

    36. Sodium 2-[4-(2-oxocyclopentylmethyl) Phenyl]-propionate Dihydrate

    37. Sodium 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoate--water (1/1/2)

    38. Sodium 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoate--water (1/2)

    39. Benzeneacetic Acid, .alpha.-methyl-4-((2-oxocyclopentyl)methyl)-, Sodium Salt, Hydrate (1:1:2)

    2.4 Create Date
    2008-02-05
    3 Chemical and Physical Properties
    Molecular Weight 304.31 g/mol
    Molecular Formula C15H21NaO5
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count4
    Exact Mass304.12866805 g/mol
    Monoisotopic Mass304.12866805 g/mol
    Topological Polar Surface Area59.2 Ų
    Heavy Atom Count21
    Formal Charge0
    Complexity321
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count4
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents, Non-Steroidal

    Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)