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    Magnesium Salicylate

    ACTIVE PHARMA INGREDIENTS

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    2D Structure
    Also known as: 18917-89-0, Magnesium disalicylate, Magnesiumsalicylate, Magan, Magnesium salicylate anhydrous, Jq69d454n1
    Molecular Formula
    C14H10MgO6
    Molecular Weight
    298.53  g/mol
    InChI Key
    MQHWFIOJQSCFNM-UHFFFAOYSA-L
    FDA UNII
    JQ69D454N1
    Magnesium salicylate is a non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain. It is available in several over-the-counter (OTC) formulations. Though the recommended doseage is 1160 mg every six hours, per package directions of the Doan's OTC brand (580 mg magnesium salicylate tetrahydrate, equivalent to 934.4 mg anhydrous magnesium salicylate), effective pain relief is often found with a half dosage, with reduced anti-inflammatory results.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    magnesium;2-carboxyphenolate
    2.1.2 InChI
    InChI=1S/2C7H6O3.Mg/c2*8-6-4-2-1-3-5(6)7(9)10;/h2*1-4,8H,(H,9,10);/q;;+2/p-2
    2.1.3 InChI Key
    MQHWFIOJQSCFNM-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    C1=CC=C(C(=C1)C(=O)O)[O-].C1=CC=C(C(=C1)C(=O)O)[O-].[Mg+2]
    2.2 Other Identifiers
    2.2.1 UNII
    JQ69D454N1
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Keygesic-10

    2. Magan

    3. Mobidin

    4. Momentum (magnesium Salicylate)

    2.3.2 Depositor-Supplied Synonyms

    1. 18917-89-0

    2. Magnesium Disalicylate

    3. Magnesiumsalicylate

    4. Magan

    5. Magnesium Salicylate Anhydrous

    6. Jq69d454n1

    7. Mobidin

    8. Magnesium, Bis[2-(hydroxy-.kappa.o)benzoato-.kappa.o]-, (t-4)-

    9. Backache Relief

    10. Chebi:6640

    11. Bis(salicylato)magnesium; Magan; Magnesium Bis(salicylate); Salicylic Acid, Magnesium Salt

    12. Bis(salicylato)magnesium

    13. Magnesium Bis(salicylate)

    14. Unii-jq69d454n1

    15. Magnesium, Bis(2-(hydroxy-.kappa.o)benzoato-.kappa.o)-, (t-4)-

    16. Einecs 242-669-3

    17. Analate

    18. Lorisal

    19. Triact

    20. Salicylic Acid, Magnesium Salt (2:1)

    21. Magnesium;2-carboxyphenolate

    22. Schembl9981

    23. Chembl2106755

    24. Dtxsid00889392

    25. Magnesium Salicylate [mi]

    26. Magnesium Salicylate (1:2)

    27. Akos015901813

    28. Db01397

    29. Magnesium, Bis(2-hydroxybenzoato-o1,o2)-

    30. Q6731407

    2.4 Create Date
    2011-12-26
    3 Chemical and Physical Properties
    Molecular Weight 298.53 g/mol
    Molecular Formula C14H10MgO6
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count2
    Exact Mass298.0327797 g/mol
    Monoisotopic Mass298.0327797 g/mol
    Topological Polar Surface Area121 Ų
    Heavy Atom Count21
    Formal Charge0
    Complexity133
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Indication

    Magnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents, Non-Steroidal

    Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

    Cyclooxygenase Inhibitors

    Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Central Nervous System Stimulation [PE]; Methylxanthine [EPC]; Xanthines [CS]; Central Nervous System Stimulant [EPC]
    5.3 Mechanism of Action

    Most NSAIDs act as nonselective inhibitors of the enzyme cyclooxygenase (COX), inhibiting both the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isoenzymes. COX catalyzes the formation of prostaglandins and thromboxane from arachidonic acid (itself derived from the cellular phospholipid bilayer by phospholipase A2). Prostaglandins act (among other things) as messenger molecules in the process of inflammation.