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    Manidipine

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    GLOBAL SALES INFORMATION

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    REF. STANDARDS & IMPURITIES

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    $ API Ref.Price (USD/KG) : 1,509Xls

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    2D Structure
    Also known as: 89226-75-5, Manidipine hydrochloride, Manidipine 2hcl, Manidipine hcl, Cv-4093, Calslot
    Molecular Formula
    C35H40Cl2N4O6
    Molecular Weight
    683.6  g/mol
    InChI Key
    JINNGBXKBDUGQT-UHFFFAOYSA-N
    FDA UNII
    ZL507UZ6QL
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;dihydrochloride
    2.1.2 InChI
    InChI=1S/C35H38N4O6.2ClH/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27;;/h4-16,23,32-33,36H,17-22H2,1-3H3;2*1H
    2.1.3 InChI Key
    JINNGBXKBDUGQT-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(C(C(=C(N1)C)C(=O)OCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC.Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    ZL507UZ6QL
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (+)-manidipine

    2. (+)-manidipine Dihydrochloride

    3. (-)-manidipine

    4. (-)-manidipine Dihydrochloride

    5. (r)-(-)-manidipine

    6. (r)-(-)-manidipine Dihydrochloride

    7. (r)-manidipine

    8. (r)-manidipine Dihydrochloride

    9. (s)-(+)-manidipine

    10. (s)-(+)-manidipine Dihydrochloride

    11. (s)-manidipine

    12. (s)-manidipine Dihydrochloride

    13. 2-(4-diphenylmethyl-1-piperazinyl)ethyl Methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

    14. Cv 4093

    15. Cv-4093

    16. Manidipine

    17. Manidipine Hydrochloride

    18. Manidipine, (+-)-isomer

    2.3.2 Depositor-Supplied Synonyms

    1. 89226-75-5

    2. Manidipine Hydrochloride

    3. Manidipine 2hcl

    4. Manidipine Hcl

    5. Cv-4093

    6. Calslot

    7. Franidipine Hydrochloride

    8. Manidipine (dihydrochloride)

    9. Manidipine.2hcl

    10. 3-(2-(4-benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Dihydrochloride

    11. Manidipine Hydrochloride [jan]

    12. 126229-12-7

    13. Zl507uz6ql

    14. Cv4093

    15. Cv 4093

    16. 5-o-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-o-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;dihydrochloride

    17. 89226-75-5 (hcl)

    18. Dsstox_cid_796

    19. Dsstox_rid_75794

    20. Dsstox_gsid_20796

    21. Cas-89226-75-5

    22. (+-)-manidipine Hydrochloride

    23. Ncgc00167493-01

    24. Ncgc00167493-04

    25. Unii-zl507uz6ql

    26. Manidipinehcl

    27. Calslot (tn)

    28. Schembl247919

    29. Chembl2362693

    30. Dtxsid9020796

    31. Chebi:31800

    32. Manidipine Hydrochloride (jp17)

    33. Bcp22692

    34. Tox21_112494

    35. Mfcd00896434

    36. Akos015920141

    37. Tox21_112494_1

    38. Ac-2117

    39. Ccg-270371

    40. Cs-1132

    41. Ks-1270

    42. Manidipine Dihydrochloride (cv-4093)

    43. Manidipine Dihydrochloride [mi]

    44. Manidipine Hydrochloride [mart.]

    45. Manidipine Hydrochloride [who-dd]

    46. 2-[4-(diphenylmethyl)piperazin-1-yl]ethyl Methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Dihydrochloride

    47. 3,5-pyridinedicarboxylic Acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(diphenylmethyl)-1-piperazinyl)ethyl Methyl Ester, Dihydrochloride

    48. Hy-17403

    49. Db-057119

    50. Ft-0630961

    51. M2225

    52. S2482

    53. Sw219348-1

    54. D01553

    55. 226m506

    56. Q27295683

    57. 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester Dihydrochloride

    58. 2-(4-(diphenylmethyl)-1-piperazinyl)ethyl Methyl (+/-)-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinecarboxylate Dihydrochloride

    59. 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl Methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarbo

    60. 3,5-pyridinedicarboxylic Acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-(4-(diphenylmethyl)-1-piperazinyl)ethyl) 5-methyl Ester, Hydrochloride (1:2)

    61. 3-(2-(4-benzhydrylpiperazin-1-yl)ethyl)5-methyl2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylatedihydrochloride

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 683.6 g/mol
    Molecular Formula C35H40Cl2N4O6
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count11
    Exact Mass682.2324904 g/mol
    Monoisotopic Mass682.2324904 g/mol
    Topological Polar Surface Area117 Ų
    Heavy Atom Count47
    Formal Charge0
    Complexity1090
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Calcium Channel Blockers

    A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)