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    Meclofenamic Acid

    ACTIVE PHARMA INGREDIENTS

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    2D Structure
    Also known as: 6385-02-0, Meclomen, Meclofenamic acid sodium salt, Meclonax, Movens, Sodium meclofenamate
    Molecular Formula
    C14H10Cl2NNaO2
    Molecular Weight
    318.1  g/mol
    InChI Key
    OGPIIGMUPMPMNT-UHFFFAOYSA-M
    FDA UNII
    9MMQ0YER4E
    A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;2-(2,6-dichloro-3-methylanilino)benzoate
    2.1.2 InChI
    InChI=1S/C14H11Cl2NO2.Na/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;/h2-7,17H,1H3,(H,18,19);/q;+1/p-1
    2.1.3 InChI Key
    OGPIIGMUPMPMNT-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    CC1=C(C(=C(C=C1)Cl)NC2=CC=CC=C2C(=O)[O-])Cl.[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    9MMQ0YER4E
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Benzoic Acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, Monosodium Salt, Monohydrate

    2. Meclofenamate

    3. Meclofenamate Sodium Anhydrous

    4. Meclofenamate Sodium Monohydrate

    5. Meclofenamate, Sodium

    6. Meclofenamic Acid

    7. Meclomen

    8. Sodium Meclofenamate

    2.3.2 Depositor-Supplied Synonyms

    1. 6385-02-0

    2. Meclomen

    3. Meclofenamic Acid Sodium Salt

    4. Meclonax

    5. Movens

    6. Sodium Meclofenamate

    7. Meclofenamic Acid Sodium

    8. Meclofenamic Acid (sodium)

    9. Meclodium

    10. Sodium 2-((2,6-dichloro-3-methylphenyl)amino)benzoate

    11. Meclofenamate (sodium)

    12. 9mmq0yer4e

    13. 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic Acid Sodium Salt

    14. Sodium;2-(2,6-dichloro-3-methylanilino)benzoate

    15. Mls000069578

    16. Chebi:6711

    17. Benzoic Acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, Monosodium Salt

    18. Smr000058785

    19. Meclomen (tn)

    20. Sodium Meclophenamate

    21. Chembl876

    22. Cl-583.na Salt

    23. Meclofenamate Sodium Anhydrous

    24. Nsc-757088

    25. Benzoic Acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, Monosodium Salt, Monohydrate

    26. Einecs 228-983-3

    27. Unii-9mmq0yer4e

    28. Ci 583

    29. Mfcd00077376

    30. Meclofenamate Sodium [usan:usp]

    31. Monosodium N-(2,6-dichloro-m-tolyl)anthranilate

    32. N-(2,6-dichloro-m-tolyl)anthranilic Acid Sodium Salt

    33. Benzoic Acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, Sodium Salt (1:1)

    34. Opera_id_596

    35. Anthranilic Acid, N-(2,6-dichloro-m-tolyl)-, Monosodium Salt

    36. Lopac-m-4531

    37. Mls001056523

    38. Mls001077271

    39. Schembl1649454

    40. Dtxsid8045567

    41. Sodium Meclofenamate (anhydrous)

    42. Hms501j06

    43. Hms2091b08

    44. Hms2231h18

    45. Hms3259f13

    46. Hms3262a16

    47. Hms3372d22

    48. Hms3649o09

    49. Hms3652l10

    50. Hms3885h19

    51. Hy-b1320

    52. Tox21_500727

    53. Ccg-40117

    54. S4295

    55. Meclofenamate Sodium [who-dd]

    56. Akos009157878

    57. Ccg-267676

    58. Lp00727

    59. Nc00649

    60. Nsc 757088

    61. Ncgc00016169-01

    62. Ncgc00016169-02

    63. Ncgc00016169-03

    64. Ncgc00094073-01

    65. Ncgc00094073-02

    66. Ncgc00261412-01

    67. Db-054565

    68. 2-(2,6-dichloro-3-methyl-anilino)benzoate

    69. Cs-0013081

    70. Eu-0100727

    71. Ft-0603690

    72. M1269

    73. Sw219723-1

    74. En300-51912

    75. A12520

    76. C02996

    77. D08162

    78. D81964

    79. M 4531

    80. Q27107307

    81. Sodium 2-(2,6-dichloro-3-methylphenylamino)benzoate

    82. Sodium2-((2,6-dichloro-3-methylphenyl)amino)benzoate

    83. 2-([2,6-dichloro-3-methylphenyl]amino)benzoic Acid Sodium

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 318.1 g/mol
    Molecular Formula C14H10Cl2NNaO2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count3
    Exact Mass316.9986282 g/mol
    Monoisotopic Mass316.9986282 g/mol
    Topological Polar Surface Area52.2 Ų
    Heavy Atom Count20
    Formal Charge0
    Complexity332
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameMeclofenamate sodium
    PubMed HealthMeclofenamate Sodium (By mouth)
    Drug ClassesAnalgesic, Antimigraine, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent
    Drug LabelMeclofenamate sodium, USP is N-(2,6-dichloro-m-tolyl) anthranilic acid, sodium salt, monohydrate. It is an anti-inflammatory drug for oral administration. Meclofenamate sodium capsules, USP contain 50 mg or 100 mg meclofenamic acid as the sodium salt...
    Active IngredientMeclofenamate sodium
    Dosage FormCapsule
    RouteOral
    Strengtheq 100mg base; eq 50mg base
    Market StatusPrescription
    CompanyMylan

    2 of 2  
    Drug NameMeclofenamate sodium
    PubMed HealthMeclofenamate Sodium (By mouth)
    Drug ClassesAnalgesic, Antimigraine, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent
    Drug LabelMeclofenamate sodium, USP is N-(2,6-dichloro-m-tolyl) anthranilic acid, sodium salt, monohydrate. It is an anti-inflammatory drug for oral administration. Meclofenamate sodium capsules, USP contain 50 mg or 100 mg meclofenamic acid as the sodium salt...
    Active IngredientMeclofenamate sodium
    Dosage FormCapsule
    RouteOral
    Strengtheq 100mg base; eq 50mg base
    Market StatusPrescription
    CompanyMylan

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents, Non-Steroidal

    Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

    Cyclooxygenase Inhibitors

    Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)