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Technical details about MEN1703, learn more about the structure, uses, toxicity, action, side effects and more

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2D Structure
1. Also known as: Sel24-b489, Sel-24 free base, 9m7x64vtli, Sel24-b289, 1616359-00-2, 1h-benzimidazole, 5,6-dibromo-1-(1-methylethyl)-4-nitro-2-(4-piperidinyl)-
Molecular Formula
C15H18Br2N4O2
Molecular Weight
446.14  g/mol
InChI Key
UOUBCIJIWDLRGM-UHFFFAOYSA-N
FDA UNII
9M7X64VTLI

PIM/FLT3 Kinase Inhibitor SEL24 is an orally available inhibitor of PIM family serine/threonine protein kinases and mutant forms of FMS-related tyrosine kinase 3 (FLT3; STK1) with potential antineoplastic activity. PIM/FLT3 kinase inhibitor SEL24 binds to and inhibits the kinase activities of PIM-1, -2 and -3, and mutant forms of FLT3, which may result in the interruption of the G1/S phase cell cycle transition, an inhibition of cell proliferation, and an induction of apoptosis in tumor cells that overexpress PIMs or express mutant forms of FLT3. FLT3, a tyrosine kinase receptor that is overexpressed or mutated in various cancers, plays a role in signaling pathways that regulate hematopoietic progenitor cell proliferation, and in leukemic cell proliferation and survival. PIM kinases, downstream effectors of many cytokine and growth factor signaling pathways, including the FLT3 signaling pathway, play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies.
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5,6-dibromo-4-nitro-2-piperidin-4-yl-1-propan-2-ylbenzimidazole
2.1.2 InChI
InChI=1S/C15H18Br2N4O2/c1-8(2)20-11-7-10(16)12(17)14(21(22)23)13(11)19-15(20)9-3-5-18-6-4-9/h7-9,18H,3-6H2,1-2H3
2.1.3 InChI Key
UOUBCIJIWDLRGM-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)N1C2=CC(=C(C(=C2N=C1C3CCNCC3)[N+](=O)[O-])Br)Br
2.2 Other Identifiers
2.2.1 UNII
9M7X64VTLI
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Sel24-b489

2. Sel-24 Free Base

3. 9m7x64vtli

4. Sel24-b289

5. 1616359-00-2

6. 1h-benzimidazole, 5,6-dibromo-1-(1-methylethyl)-4-nitro-2-(4-piperidinyl)-

7. 5,6-dibromo-1-(1-methylethyl)-4-nitro-2-(4-piperidinyl)-1h-benzimidazole

8. 5,6-dibromo-4-nitro-2-(piperidin-4-yl)-1-(propan-2-yl)-1h-1,3-benzimidazole

9. Unii-9m7x64vtli

10. Chembl4467168

11. Schembl15826208

12. Hy-120758

13. Cs-0079085

2.4 Create Date
2014-07-28
3 Chemical and Physical Properties
Molecular Weight 446.14 g/mol
Molecular Formula C15H18Br2N4O2
XLogP33.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass445.97760 g/mol
Monoisotopic Mass443.97965 g/mol
Topological Polar Surface Area75.7 Ų
Heavy Atom Count23
Formal Charge0
Complexity442
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
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