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    Mephenesin

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    PharmaCompass
    $ API Ref.Price (USD/KG) : 16Xls

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    2D Structure
    Also known as: 59-47-2, Cresoxydiol, Decontractyl, Memphenesin, Mephenesine, Mephedan
    Molecular Formula
    C10H14O3
    Molecular Weight
    182.22  g/mol
    InChI Key
    JWDYCNIAQWPBHD-UHFFFAOYSA-N
    FDA UNII
    7B8PIR2954
    A centrally acting muscle relaxant with a short duration of action.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-(2-methylphenoxy)propane-1,2-diol
    2.1.2 InChI
    InChI=1S/C10H14O3/c1-8-4-2-3-5-10(8)13-7-9(12)6-11/h2-5,9,11-12H,6-7H2,1H3
    2.1.3 InChI Key
    JWDYCNIAQWPBHD-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=CC=CC=C1OCC(CO)O
    2.2 Other Identifiers
    2.2.1 UNII
    7B8PIR2954
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Dcontractyl

    2. Dolo Visano M

    2.3.2 Depositor-Supplied Synonyms

    1. 59-47-2

    2. Cresoxydiol

    3. Decontractyl

    4. Memphenesin

    5. Mephenesine

    6. Mephedan

    7. Lissephen

    8. Tolserol

    9. Anatensin

    10. Cresodiol

    11. Decontractil

    12. Dioloxol

    13. Lissenphan

    14. Mefenesina

    15. Mephelor

    16. Mephesin

    17. Myodetensin

    18. Myodetensine

    19. Atensin

    20. Curaril

    21. Sinan

    22. Kresoxypropandiol

    23. Cresoxypropanediol

    24. 3-(2-methylphenoxy)propane-1,2-diol

    25. Cresossidiolo

    26. Curarythan

    27. Seconesinz

    28. Spartoloxin

    29. Spartoloxyn

    30. Curythan

    31. Daserol

    32. Diloxol

    33. Dioloxal

    34. Findolar

    35. Findolor

    36. Glukresin

    37. Glykresin

    38. Glyotol

    39. Halabar

    40. Kinavosyl

    41. Mephate

    42. Mepherol

    43. Mephosal

    44. Mephson

    45. Mervaldin

    46. Mianesina

    47. Miolisina

    48. Moctynol

    49. Myanesin

    50. Myastenin

    51. Myocuran

    52. Myolysin

    53. Myosera

    54. Myoserol

    55. Myoxane

    56. Nembusen

    57. Nephelor

    58. Noctynol

    59. Oranixon

    60. Prolaxin

    61. Proloxin

    62. Relaxant

    63. Relaxar

    64. Relaxil

    65. Relaxyl

    66. Renarcol

    67. Sansdolor

    68. Saserol

    69. Spasmolyn

    70. Stilalgin

    71. Thioxidil

    72. Thoxidil

    73. Tokerol

    74. Tolansin

    75. Tolbart

    76. Tolhart

    77. Tolofren

    78. Tolosate

    79. Toloxyn

    80. Tolulexin

    81. Tolulox

    82. Tolydrin

    83. Tolynol

    84. Tolyspaz

    85. Torulox

    86. Anxine

    87. Avesyl

    88. Avosyl

    89. Avoxil

    90. Avoxyl

    91. Daserd

    92. Glytol

    93. Mephin

    94. Myanil

    95. Myanol

    96. Myasin

    97. Myolax

    98. Myopan

    99. Myopen

    100. Myopna

    101. Myoten

    102. Myoxyl

    103. Ortol

    104. Prolax

    105. Temian

    106. Tolax

    107. Tolcil

    108. Tolsil

    109. Tolsin

    110. Xeral

    111. Rhex Regulans

    112. Walko-nesin

    113. 1,2-propanediol, 3-(2-methylphenoxy)-

    114. 3-(2-methylphenoxy)-1,2-propanediol

    115. Cresossipropandiolo

    116. Rhex 'hobeino'

    117. O-cresyl Glycerol Ether

    118. Glyceryl O-tolyl Ether

    119. Ageflex Cge

    120. O-cresol Glyceryl Ether

    121. 3-(o-tolyloxy)propane-1,2-diol

    122. 1-o-tolylglycerol Ether

    123. Mephenesinum

    124. Mephensin

    125. O-kresol-glycerinaether

    126. Byk-m 1

    127. 3-o-toloxy-1,2-propanediol

    128. 3-(o-methylphenoxy)-1,2-propanediol

    129. Bdh 312

    130. 1-ortho-tolylglycerol Ether

    131. 3-(o-tolyloxy)-1,2-propanediol

    132. 3-(2-tolyloxy)-1,2-propanediol

    133. Walconesin

    134. Mycocuran

    135. Tolseron

    136. Mc 2303

    137. Rp 3602

    138. Sq 1156

    139. 1,2-dihydroxy-3-(2-methylphenoxy)propane

    140. A 1141

    141. Nsc-25234

    142. Mefensina

    143. Rex Regulans

    144. 1,2-propanediol, 3-(o-tolyloxy)-

    145. Walco-nesin

    146. O-cresyl .alpha.-glyceryl Ether

    147. .alpha.-(o-tolyl)glyceryl Ether

    148. 7b8pir2954

    149. Mephenesin (inn)

    150. Nsc25234

    151. Component Of Tolagesic

    152. Ncgc00094908-01

    153. Mephenesin [inn]

    154. Dsstox_cid_3254

    155. 1, 3-(o-tolyloxy)-

    156. Dsstox_rid_76942

    157. Wln: Q1yq1or B1

    158. Dsstox_gsid_23254

    159. 1, 3-(2-methylphenoxy)-

    160. .alpha.,.beta.-dihydroxy-.gamma.-(2-methylphenoxy)propane

    161. Mefenesina [inn-spanish]

    162. Mephenesine [inn-french]

    163. Mephenesinum [inn-latin]

    164. O-cresyl Alpha-glyceryl Ether

    165. Alpha-(o-tolyl)glyceryl Ether

    166. O-kresol-glycerinaether [german]

    167. Sr-05000001772

    168. Einecs 200-427-4

    169. Nsc 25234

    170. Brn 2047373

    171. Mephenesin [inn:ban:nf]

    172. Rhex

    173. Unii-7b8pir2954

    174. Cas-59-47-2

    175. Tolserol (tn)

    176. Prestwick_577

    177. Alpha,beta-dihydroxy-gamma-(2-methylphenoxy)propane

    178. Mephenesin, 98%

    179. 1-(o-tolyl)glycerol

    180. 1-(2-tolyl)glycerol

    181. Spectrum_001402

    182. Mephenesin [mi]

    183. Prestwick0_000178

    184. Prestwick1_000178

    185. Prestwick2_000178

    186. Prestwick3_000178

    187. Spectrum2_001418

    188. Spectrum3_000908

    189. Spectrum4_001007

    190. Spectrum5_001199

    191. (.+/-.)-mephenesin

    192. Mephenesin [mart.]

    193. 1-(2-methylphenyl)glycerol

    194. Mephenesin [who-dd]

    195. Schembl25448

    196. Bspbio_000075

    197. Kbiogr_001473

    198. Kbioss_001882

    199. Divk1c_000076

    200. Spectrum1501140

    201. Spbio_001496

    202. Spbio_001996

    203. Bpbio1_000083

    204. Chembl229128

    205. Dtxsid4023254

    206. Chebi:94398

    207. Hms500d18

    208. Kbio1_000076

    209. Kbio2_001882

    210. Kbio2_004450

    211. Kbio2_007018

    212. Kbio3_001856

    213. Nsc8134

    214. Ninds_000076

    215. Hms1568d17

    216. Hms1921j09

    217. Hms2092f17

    218. Hms2095d17

    219. Hms3712d17

    220. Hms3886k09

    221. Pharmakon1600-01501140

    222. Hy-b1283

    223. Nsc-8134

    224. Nsc36140

    225. Nsc50788

    226. Glycerol-1-(o-tolyl) Ether

    227. Tox21_111356

    228. Ccg-38970

    229. Mfcd00004718

    230. Nsc-36140

    231. Nsc-50788

    232. Nsc757857

    233. S5032

    234. Stl430456

    235. Akos015912866

    236. Tox21_111356_1

    237. Cs-5340

    238. Db13583

    239. Nsc-757857

    240. Idi1_000076

    241. 1,2-propanediol, 3-(2-methylphenoxy)

    242. Ncgc00094908-02

    243. Ncgc00094908-03

    244. Ncgc00094908-06

    245. 3-[(2-methylphenyl)oxy]propane-1,2-diol

    246. Sbi-0051654.p002

    247. Ab00052216

    248. Ft-0628209

    249. M3076

    250. 3-(2-methylphenoxy)-1,2-propanediol, 98%

    251. D02595

    252. D97581

    253. Ab00052216_04

    254. A923330

    255. Q3333250

    256. Sr-05000001772-1

    257. Sr-05000001772-2

    258. Sr-05000001772-3

    259. Brd-a55469827-001-01-7

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 182.22 g/mol
    Molecular Formula C10H14O3
    XLogP31.4
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count4
    Exact Mass182.094294304 g/mol
    Monoisotopic Mass182.094294304 g/mol
    Topological Polar Surface Area49.7 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity138
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Mephenesin was used for the treatment of muscle spasticity in diseases like Parkinson's or Multiple Sclerosis.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Mephenesin reduced neuronal excitability leading to decreases action potentials to muscle fibers which ultimately produces a reduction in spasticity.

    5.2 MeSH Pharmacological Classification

    Muscle Relaxants, Central

    A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)

    5.3 ATC Code

    M - Musculo-skeletal system

    M03 - Muscle relaxants

    M03B - Muscle relaxants, centrally acting agents

    M03BX - Other centrally acting agents

    M03BX06 - Mephenesin

    5.4 Mechanism of Action

    The exact mechanism of action of mephenesin is not known. It has been observed to block both inward sodium and inward calcium currents in neurons. It has a physiological effect which opposes that of strychnine.