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    Mepirizole

    ACTIVE PHARMA INGREDIENTS

    PharmaCompass
    Xls

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    2D Structure
    Also known as: Mepirizole, 18694-40-1, Mebron, Methopyrimazole, 4-methoxy-2-(5-methoxy-3-methyl-1h-pyrazol-1-yl)-6-methylpyrimidine, Mepirizol
    Molecular Formula
    C11H14N4O2
    Molecular Weight
    234.25  g/mol
    InChI Key
    RHAXSHUQNIEUEY-UHFFFAOYSA-N
    FDA UNII
    3B46O2FH8I
    4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine. A pyrimidinyl pyrazole with antipyretic, analgesic, and anti-inflammatory activity.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine
    2.1.2 InChI
    InChI=1S/C11H14N4O2/c1-7-5-9(16-3)13-11(12-7)15-10(17-4)6-8(2)14-15/h5-6H,1-4H3
    2.1.3 InChI Key
    RHAXSHUQNIEUEY-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=CC(=NC(=N1)N2C(=CC(=N2)C)OC)OC
    2.2 Other Identifiers
    2.2.1 UNII
    3B46O2FH8I
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Mepirizole

    2. Methopyrimazole

    2.3.2 Depositor-Supplied Synonyms

    1. Mepirizole

    2. 18694-40-1

    3. Mebron

    4. Methopyrimazole

    5. 4-methoxy-2-(5-methoxy-3-methyl-1h-pyrazol-1-yl)-6-methylpyrimidine

    6. Mepirizol

    7. Da-398

    8. Epirizolum [inn-latin]

    9. 4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine

    10. Pyrimidine, 4-methoxy-2-(5-methoxy-3-methyl-1h-pyrazol-1-yl)-6-methyl-

    11. Mls000028844

    12. 3b46o2fh8i

    13. 1-(4-methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole

    14. 2-(3-methoxy-5-methylpyrazol-2-yl)-4-methoxy-6-methylpyrimidine

    15. 2-(3-methyl-5-methoxy-1-pyrazolyl)-4-methoxy-6-methylpyrimidine

    16. Ncgc00016737-01

    17. Smr000058715

    18. 4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidin

    19. Cas-18694-40-1

    20. Dsstox_cid_25422

    21. Dsstox_rid_80869

    22. Dsstox_gsid_45422

    23. Mepirizol [german]

    24. Epirizolum

    25. Epirizol

    26. Epirizol [inn-spanish]

    27. Pyrimidine,4-methoxy-2-(5-methoxy-3-methyl-1h-pyrazol-1-yl)-6-methyl-

    28. Epirizole [usan:inn:jan]

    29. Einecs 242-507-1

    30. Brn 0751084

    31. Unii-3b46o2fh8i

    32. Prestwick_201

    33. Mebron (tn)

    34. Epirizole [inn]

    35. Epirizole [jan]

    36. Opera_id_598

    37. Epirizole [mi]

    38. Epirizole [usan]

    39. Prestwick0_000032

    40. Prestwick1_000032

    41. Prestwick2_000032

    42. Prestwick3_000032

    43. Epirizole [mart.]

    44. 4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidin [german]

    45. Epirizole (jp17/usan)

    46. Epirizole [who-dd]

    47. Schembl23765

    48. Bspbio_000123

    49. 5-25-18-00012 (beilstein Handbook Reference)

    50. Mls001148256

    51. Mls001424179

    52. Spbio_002044

    53. Mepirizole, Analytical Standard

    54. Bpbio1_000137

    55. Chembl1411693

    56. Dtxsid4045422

    57. Chebi:31545

    58. Zinc57412

    59. Hms1568g05

    60. Hms2052a07

    61. Hms2095g05

    62. Hms2232e23

    63. Hms3370d19

    64. Hms3394a07

    65. Hms3712g05

    66. Tox21_110584

    67. Pyrimidine, 4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methyl-

    68. Akos016000700

    69. Tox21_110584_1

    70. Ccg-101087

    71. Db08991

    72. Nc00337

    73. Ncgc00016737-02

    74. Ncgc00016737-04

    75. Hy-103595

    76. Cs-0022015

    77. Ft-0637738

    78. Mls000028844-02

    79. D01394

    80. 694m401

    81. Sr-01000721915

    82. J-012020

    83. Q5383219

    84. Sr-01000721915-3

    85. Brd-k39339537-001-03-8

    86. 2-(3-methyl-5-methoxy-1-pyrazolyl)-4-methoxy-6-methyl-pyrimidine

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 234.25 g/mol
    Molecular Formula C11H14N4O2
    XLogP31.3
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count3
    Exact Mass234.11167570 g/mol
    Monoisotopic Mass234.11167570 g/mol
    Topological Polar Surface Area62.1 Ų
    Heavy Atom Count17
    Formal Charge0
    Complexity254
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents, Non-Steroidal

    Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)