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    Mesna

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    RELATED EXCIPIENT COMPANIES

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    $ API Ref.Price (USD/KG) : 765Xls

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    2D Structure
    Also known as: 19767-45-4, Sodium 2-mercaptoethanesulfonate, Uromitexan, Mesnex, Mitexan, Mistabron
    Molecular Formula
    C2H5NaO3S2
    Molecular Weight
    164.18  g/mol
    InChI Key
    XOGTZOOQQBDUSI-UHFFFAOYSA-M
    FDA UNII
    NR7O1405Q9
    A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;2-sulfanylethanesulfonate
    2.1.2 InChI
    InChI=1S/C2H6O3S2.Na/c3-7(4,5)2-1-6;/h6H,1-2H2,(H,3,4,5);/q;+1/p-1
    2.1.3 InChI Key
    XOGTZOOQQBDUSI-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    C(CS(=O)(=O)[O-])S.[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    NR7O1405Q9
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2 Mercaptoethanesulfonate

    2. 2-mercaptoethanesulfonate

    3. 2-mercaptoethanesulphonate, Sodium

    4. Asta D 7093

    5. Asta-d 7093

    6. Astad 7093

    7. Coenzyme M

    8. Ethanesulfonic Acid, 2-mercapto-, Monosodium Salt

    9. Mesna Cell

    10. Mesna-cell

    11. Mesnex

    12. Mesnum

    13. Mistabron

    14. Mistabronco

    15. Mitexan

    16. Mucofluid

    17. Sodium 2-mercaptoethanesulphonate

    18. Ucb 3983

    19. Ucb-3983

    20. Ucb3983

    21. Uromitexan

    22. Ziken

    2.3.2 Depositor-Supplied Synonyms

    1. 19767-45-4

    2. Sodium 2-mercaptoethanesulfonate

    3. Uromitexan

    4. Mesnex

    5. Mitexan

    6. Mistabron

    7. Mesnum

    8. 2-mercaptoethanesulfonic Acid Sodium Salt

    9. Mistabronco

    10. Sodium 2-mercaptoethane Sulfonate

    11. Ethanesulfonic Acid, 2-mercapto-, Monosodium Salt

    12. Coenzyme M Sodium Salt

    13. Sodium;2-sulfanylethanesulfonate

    14. 2-mercaptoethanesulfonate, Sodium

    15. 2-mercaptoethanesulfonic Acid Sodium

    16. Sodium 2-mercaptoethanesulfonate;mesnum

    17. Sodium 2-sulfanylethane-1-sulfonate

    18. D 7093

    19. D-7093

    20. Nr7o1405q9

    21. Nsc-113891

    22. Ncgc00181166-01

    23. Dsstox_cid_809

    24. Dsstox_rid_75800

    25. Dsstox_gsid_20809

    26. Mesnum [inn-latin]

    27. Smr000059219

    28. Cas-19767-45-4

    29. Natrium 2-mercaptoethansulfonat

    30. Ccris 3712

    31. 2-mercaptoethane Sulfonate Sodium

    32. Sodium 2-mercaptoethanesulphonate

    33. Einecs 243-285-9

    34. Nsc 113891

    35. Unii-nr7o1405q9

    36. 2-mercapto-ethan-sulfonsaeure, Natrium-salz

    37. 2-mercaptoethanesulfonic Acid Monosodium Salt

    38. Mesna [usan:usp:inn:ban]

    39. Uromitexan (tn)

    40. Sodium 2-mercaptoethane-1-sulfonate

    41. Mesnex (tn)

    42. Mfcd00007535

    43. Prestwick_1005

    44. Mesna [vandf]

    45. Mesna [usan]

    46. Spectrum2_000752

    47. Spectrum3_001483

    48. Spectrum4_000041

    49. Spectrum5_001174

    50. Mesna [inn]

    51. Mesna [jan]

    52. Mesna [who-dd]

    53. Mesna [mart.]

    54. Mesna [mi]

    55. Mesna (jan/usp/inn)

    56. Chembl975

    57. Schembl7993

    58. Mesna (uromitexan, Mesnex)

    59. Mesna [orange Book]

    60. Kbiogr_000501

    61. Mesna [ep Monograph]

    62. Mesna [usp Impurity]

    63. Mls001074691

    64. Mls001333251

    65. Mls001333252

    66. Mesna [usp Monograph]

    67. Spectrum1502014

    68. Sodium2-mercaptoethanesulfonate

    69. Spbio_000764

    70. Dtxsid1020809

    71. Chebi:31824

    72. Hms502f17

    73. Kbio3_002565

    74. Hms1921d10

    75. Hms2092n09

    76. Hms2236l05

    77. Hms3259d13

    78. Hms3372m11

    79. Hms3655m06

    80. Hms3715h05

    81. Sodium, 2-mercapto-ethanesulfonate

    82. Bcp14384

    83. Tox21_112767

    84. Tox21_200863

    85. Bdbm50247978

    86. Ccg-40134

    87. S1735

    88. Akos006220661

    89. Akos015960755

    90. Tox21_112767_1

    91. Ac-6011

    92. Cs-1364

    93. Nc00648

    94. Ncgc00094939-01

    95. Ncgc00094939-02

    96. Ncgc00178318-04

    97. Ncgc00258417-01

    98. Sodium 2-sulphanylethanesulphonate

    99. 2-mercaptoethanesulphonic Acid Sodium Salt

    100. As-13260

    101. Hy-13679

    102. Db-044962

    103. A8469

    104. M0913

    105. Sw199618-2

    106. En300-49858

    107. D01459

    108. Ab01274734-01

    109. Q424997

    110. W-60283

    111. Q-201713

    112. 3-aminooxy-n-propyl(dimethyl-t-butylsilyl)ether

    113. Z1741968275

    2.4 Create Date
    2008-02-05
    3 Chemical and Physical Properties
    Molecular Weight 164.18 g/mol
    Molecular Formula C2H5NaO3S2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count2
    Exact Mass163.95778065 g/mol
    Monoisotopic Mass163.95778065 g/mol
    Topological Polar Surface Area66.6 Ų
    Heavy Atom Count8
    Formal Charge0
    Complexity123
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameMesna
    PubMed HealthMesna
    Drug ClassesHemorrhagic Cystitis Inhibitor
    Drug LabelMesna is a detoxifying agent to inhibit the hemorrhagic cystitis induced by ifosfamide. The active ingredient mesna is a synthetic sulfhydryl compound designated as sodium-2-mercaptoethane sulfonate with a molecular formula of C2H5NaO3S2 and a molecu...
    Active IngredientMesna
    Dosage FormInjectable
    Routeinjection; Intravenous
    Strength1g/10ml; 100mg/ml
    Market StatusPrescription
    CompanyTeva Pharms Usa; Fresenius Kabi Usa; Mylan Institutional; Sagent Pharms; Eurohlth Intl; Agila Speclts

    2 of 4  
    Drug NameMesnex
    PubMed HealthMesna (By mouth)
    Drug ClassesHemorrhagic Cystitis Inhibitor
    Drug LabelMesna is a detoxifying agent to inhibit the hemorrhagic cystitis induced by ifosfamide (IFEX). The active ingredient mesna is a synthetic sulfhydryl compound designated as sodium-2-mercaptoethane sulfonate with a molecular formula of C2H5NaO3S2 and a...
    Active IngredientMesna
    Dosage FormTablet; Injectable
    RouteOral; Intravenous
    Strength400mg; 100mg/ml
    Market StatusPrescription
    CompanyBaxter Hlthcare

    3 of 4  
    Drug NameMesna
    PubMed HealthMesna
    Drug ClassesHemorrhagic Cystitis Inhibitor
    Drug LabelMesna is a detoxifying agent to inhibit the hemorrhagic cystitis induced by ifosfamide. The active ingredient mesna is a synthetic sulfhydryl compound designated as sodium-2-mercaptoethane sulfonate with a molecular formula of C2H5NaO3S2 and a molecu...
    Active IngredientMesna
    Dosage FormInjectable
    Routeinjection; Intravenous
    Strength1g/10ml; 100mg/ml
    Market StatusPrescription
    CompanyTeva Pharms Usa; Fresenius Kabi Usa; Mylan Institutional; Sagent Pharms; Eurohlth Intl; Agila Speclts

    4 of 4  
    Drug NameMesnex
    PubMed HealthMesna (By mouth)
    Drug ClassesHemorrhagic Cystitis Inhibitor
    Drug LabelMesna is a detoxifying agent to inhibit the hemorrhagic cystitis induced by ifosfamide (IFEX). The active ingredient mesna is a synthetic sulfhydryl compound designated as sodium-2-mercaptoethane sulfonate with a molecular formula of C2H5NaO3S2 and a...
    Active IngredientMesna
    Dosage FormTablet; Injectable
    RouteOral; Intravenous
    Strength400mg; 100mg/ml
    Market StatusPrescription
    CompanyBaxter Hlthcare

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Protective Agents

    Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent. (See all compounds classified as Protective Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Cytoprotective Agent [EPC]
    5.3 ATC Code

    R - Respiratory system

    R05 - Cough and cold preparations

    R05C - Expectorants, excl. combinations with cough suppressants

    R05CB - Mucolytics

    R05CB05 - Mesna

    V - Various

    V03 - All other therapeutic products

    V03A - All other therapeutic products

    V03AF - Detoxifying agents for antineoplastic treatment

    V03AF01 - Mesna