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1. (3-iodo-(131i)benzyl)guanidine
2. 123i Labeled 3-iodobenzylguanidine
3. 125i Labeled 3-iodobenzylguanidine
4. 3 Iodobenzylguanidine
5. 3 Iodobenzylguanidine, 123i Labeled
6. 3 Iodobenzylguanidine, 125i Labeled
7. 3-iodobenzylguanidine
8. 3-iodobenzylguanidine, 123i Labeled
9. 3-iodobenzylguanidine, 125i Labeled
10. Iobenguane (131i)
11. M Iodobenzylguanidine
12. M-iodobenzylguanidine
13. Meta Iodobenzylguanidine
14. Meta-iodobenzylguanidine
15. Mibg
1. M-iodobenzylguanidine
2. 80663-95-2
3. 3-iodobenzylguanidine
4. Metaiodobenzylguanidine
5. Mibg
6. 2-[(3-iodophenyl)methyl]guanidine
7. Iobenguane (127-i)
8. Guanidine, ((3-iodophenyl)methyl)-
9. 139755-80-9
10. Guanidine,n-[(3-iodophenyl)methyl]-
11. 1-(3-iodobenzyl)guanidine
12. 2-(3-iodobenzyl)guanidine
13. 35mrw7b4ad
14. ((3-iodophenyl)methyl)guanidine
15. Meta-iodobenzylguanidine
16. (3-iodobenzyl)guanidine
17. Ncgc00015572-04
18. Unii-35mrw7b4ad
19. Sr-01000075167
20. Prestwick-07a11
21. Starbld0001019
22. Iobenguane [mi]
23. Meta-iodobenzyl Guanidine
24. Prestwick0_000490
25. Prestwick1_000490
26. Prestwick2_000490
27. Prestwick3_000490
28. Lopac-i-9890
29. 2-m-iodo-benzyl Guanidine
30. Iobenguane [vandf]
31. Chembl818
32. Lopac0_000644
33. Bspbio_000359
34. Schembl140591
35. Spbio_002280
36. Bpbio1_000395
37. Dtxsid4048438
38. Chebi:92769
39. 1-[(3-iodophenyl)methyl]guanidine
40. Zinc1538318
41. Ccg-204731
42. Db06704
43. Sdccgsbi-0050624.p002
44. Ncgc00015572-01
45. Ncgc00015572-02
46. Ncgc00015572-03
47. Ncgc00015572-06
48. Ncgc00015572-09
49. Ncgc00162211-01
50. Da-02654
51. Q3154058
52. Sr-01000075167-1
53. Brd-k43860855-065-03-6
| Molecular Weight | 275.09 g/mol |
|---|---|
| Molecular Formula | C8H10IN3 |
| XLogP3 | 1 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 2 |
| Exact Mass | 274.99194 g/mol |
| Monoisotopic Mass | 274.99194 g/mol |
| Topological Polar Surface Area | 64.4 Ų |
| Heavy Atom Count | 12 |
| Formal Charge | 0 |
| Complexity | 166 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Detection of primary and metastatic pheochromocytoma or neuroblastoma
FDA Label
AdreView is a diagnostic radiopharmaceutical which contains a small quantity of iobenguane that is not expected to produce a pharmacodynamic effect. Patients with renal insufficiency may experience increased radiation exposure and impaired imaging results.
Radiopharmaceuticals
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161) (See all compounds classified as Radiopharmaceuticals.)
Enzyme Inhibitors
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)
Antineoplastic Agents
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)
Absorption
Iobenguane rapidly clears from the blood and is highly retained in adrenergic tissues.
Route of Elimination
Renally excreted unchanged (70%-90%) via glomerular filtration; Fecal (<1%)
Less than 10% of the dose is metabolized into m-iodohippuric acid (MIHA). However the mechanism in which this metabolite is produced is unknown.
Physical half life = 13.2 hours
Structure of iobenguane is similar to noradrenaline so it can be taken up by adrenergic tissue in the adrenal medulla, liver, heart, and spleen. Once taken up by noradrenaline transporters in the adrenergic nerve terminals, it is stored in the presynaptic storage vesicles. The radioactive iodine component is responsible for its imaging properties.
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