1. Alotec
2. Alupent
3. Astmopent
4. Metaprel
5. Metaproterenol Polistirex
6. Metaproterenol Sulfate
7. Orciprenaline
8. Orciprenaline Sulfate
9. Polistirex, Metaproterenol
1. Orciprenaline
2. 586-06-1
3. Alupent
4. Orciprenalinum
5. Orciprenalinum [inn-latin]
6. Orciprenalina [inn-spanish]
7. Orciprenaline [inn]
8. Prometa
9. 5-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,3-diol
10. Orciprenaline (inn)
11. (rs)-1-(3,5-dihydroxyphenyl)-2-isopropylaminoethanol
12. Chembl776
13. Chebi:6792
14. 5-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,3-diol
15. 1,3-benzenediol, 5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-
16. 53qog569e0
17. Nsc-757089
18. Orciprenalina
19. 1,3-benzenediol, 5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-
20. Ccris 9017
21. Th-152
22. Sr-01000075168
23. Einecs 209-569-1
24. Orciprenaline [inn:ban]
25. Brn 2807247
26. Orciprenalin
27. Unii-53qog569e0
28. 3,5-dihydroxy-alpha-((isopropylamino)methyl)benzyl Alcohol
29. Spectrum_000925
30. Prestwick0_000505
31. Prestwick1_000505
32. Prestwick2_000505
33. Prestwick3_000505
34. Spectrum2_000096
35. Spectrum3_000492
36. Spectrum4_000044
37. Spectrum5_000952
38. M-3070
39. Metaproterenol [mi]
40. Schembl4270
41. Lopac0_000734
42. Bspbio_000429
43. Bspbio_001983
44. Kbiogr_000507
45. Kbioss_001405
46. Divk1c_000645
47. Metaproterenol [vandf]
48. Spectrum1500390
49. Spbio_000052
50. Spbio_002350
51. Orciprenaline [who-dd]
52. Bpbio1_000473
53. Gtpl7250
54. Dtxsid8048529
55. Chebi:83329
56. Hms502a07
57. Hy-b1276a
58. Kbio1_000645
59. Kbio2_001405
60. Kbio2_003973
61. Kbio2_006541
62. Kbio3_001483
63. Ninds_000645
64. Hms1920l09
65. Hms2091d04
66. Hms3259j13
67. Pharmakon1600-01500390
68. Benzyl Alcohol, 3,5-dihydroxy-alpha-((isopropylamino)methyl)-
69. Bdbm50295572
70. Ccg-38914
71. Nsc757089
72. Db00816
73. Nc00651
74. Nsc 757089
75. Sdccgsbi-0050712.p005
76. Idi1_000645
77. Ncgc00015655-02
78. Ncgc00015655-03
79. Ncgc00015655-04
80. Ncgc00015655-05
81. Ncgc00015655-06
82. Ncgc00015655-14
83. Ncgc00094718-01
84. Ncgc00094718-02
85. Ncgc00094718-03
86. Sbi-0050712.p004
87. Ab00052037
88. Cs-0013668
89. C07144
90. D08300
91. 1-(3,5-dihydroxyphenyl)-2-isopropylaminoethanol
92. Ab00052037_09
93. Ab00052037_10
94. 586o061
95. L000678
96. Q416473
97. Sr-01000075168-1
98. Sr-01000075168-4
99. Brd-a07780951-001-06-3
100. 5-(1-hydroxy-2-(isopropylamino)ethyl)benzene-1,3-diol
101. 5-(1-hydroxy-2-isopropylamino-ethyl)-benzene-1,3-diol
102. 5-[1-hydroxy-2-(isopropanylamino)ethyl]benzene-1,3-diol
103. 5-[1-hydroxy-2-(isopropylamino)ethyl]-1,3-benzenediol #
104. [2-(3,5-dihydroxy-phenyl)-2-hydroxy-ethyl]-isopropyl-ammonium
105. 3,5-dihydroxy-.alpha.-((isopropylamino)methyl)benzyl Alcohol
106. 5-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,3-diol, 6
107. Benzyl Alcohol, 3,5-dihydroxy-.alpha.-((isopropylamino)methyl)-
108. [2-(3,5-dihydroxy-phenyl)-2-hydroxy-ethyl]-isopropyl-ammonium (orciprenaline)
| Molecular Weight | 211.26 g/mol |
|---|---|
| Molecular Formula | C11H17NO3 |
| XLogP3 | 0.7 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 4 |
| Exact Mass | 211.12084340 g/mol |
| Monoisotopic Mass | 211.12084340 g/mol |
| Topological Polar Surface Area | 72.7 Ų |
| Heavy Atom Count | 15 |
| Formal Charge | 0 |
| Complexity | 177 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
| 1 of 2 | |
|---|---|
| Drug Name | Metaproterenol sulfate |
| Drug Label | Metaproterenol sulfate syrup is an oral bronchodilator. Each teaspoonful (5 mL), for oral administration, contains metaproterenol sulfate 10 mg. In addition, each teaspoonful (5 mL) contains the following inactive ingredients:citric acid, edetate dis... |
| Active Ingredient | Metaproterenol sulfate |
| Dosage Form | Tablet; Syrup; Solution |
| Route | Oral; Inhalation |
| Strength | 10mg/5ml; 0.4%; 0.6%; 10mg; 20mg |
| Market Status | Prescription |
| Company | Wockhardt; Silarx; Mylan Speclt; Par Pharm |
| 2 of 2 | |
|---|---|
| Drug Name | Metaproterenol sulfate |
| Drug Label | Metaproterenol sulfate syrup is an oral bronchodilator. Each teaspoonful (5 mL), for oral administration, contains metaproterenol sulfate 10 mg. In addition, each teaspoonful (5 mL) contains the following inactive ingredients:citric acid, edetate dis... |
| Active Ingredient | Metaproterenol sulfate |
| Dosage Form | Tablet; Syrup; Solution |
| Route | Oral; Inhalation |
| Strength | 10mg/5ml; 0.4%; 0.6%; 10mg; 20mg |
| Market Status | Prescription |
| Company | Wockhardt; Silarx; Mylan Speclt; Par Pharm |
For the treatment of bronchospasm, chronic bronchitis, asthma, and emphysema.
Orciprenaline (also known as metaproterenol), a synthetic amine, is structurally and pharmacologically similar to isoproterenol. Orciprenaline is used exclusively as a bronchodilator. The pharmacological effects of beta adrenergic agonist drugs, such as orciprenaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased cAMP levels lead to relaxation of bronchial smooth muscles and inhibition of the release of inalammatory mediators from mast cells that are involved in promoting immediate hypersensitivity .
Tocolytic Agents
Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete. (See all compounds classified as Tocolytic Agents.)
Bronchodilator Agents
Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)
Sympathomimetics
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)
Adrenergic beta-2 Receptor Agonists
Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS. (See all compounds classified as Adrenergic beta-2 Receptor Agonists.)
R - Respiratory system
R03 - Drugs for obstructive airway diseases
R03A - Adrenergics, inhalants
R03AB - Non-selective beta-adrenoreceptor agonists
R03AB03 - Orciprenaline
R - Respiratory system
R03 - Drugs for obstructive airway diseases
R03C - Adrenergics for systemic use
R03CB - Non-selective beta-adrenoreceptor agonists
R03CB03 - Orciprenaline
Absorption
3% (oral bioavailability of 40%)
Hepatic and gastric. The major metabolite, orciprenaline-3-0-sulfate, is produced in the gastrointestinal tract. Orciprenaline is not metabolized by catechol-0-methyltransferase nor have glucuronide conjugates been isolated to date.
6 hours
Orciprenaline stimulates the 2-adrenergic receptor expressed in the lungs, uterus, and vasculature supplying skeletal muscles by acting as a moderately selective agonist. It exerts minimal or no effect on alpha-adrenergic receptors. Intracellularly, the actions of orciprenaline are mediated by cAMP, the production of which is augmented by beta stimulation. The drug is believed to work by activating adenylate cyclase, the enzyme responsible for producing the cellular mediator cAMP.
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