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    Metaraminol Bitartrate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 30,383Xls

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    2D Structure
    Also known as: 33402-03-8, Metaraminol tartrate, Metaraminol (+)-bitartrate salt, Metaraminol (tartrate), (-)-metaraminol bitartrate, Metaradrine tartrate
    Molecular Formula
    C13H19NO8
    Molecular Weight
    317.29  g/mol
    InChI Key
    VENXSELNXQXCNT-IJYXXVHRSA-N
    FDA UNII
    ZC4202M9P3
    A sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. It has been used primarily as a vasoconstrictor in the treatment of HYPOTENSION.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-[(1R,2S)-2-amino-1-hydroxypropyl]phenol;(2R,3R)-2,3-dihydroxybutanedioic acid
    2.1.2 InChI
    InChI=1S/C9H13NO2.C4H6O6/c1-6(10)9(12)7-3-2-4-8(11)5-7;5-1(3(7)8)2(6)4(9)10/h2-6,9,11-12H,10H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t6-,9-;1-,2-/m01/s1
    2.1.3 InChI Key
    VENXSELNXQXCNT-IJYXXVHRSA-N
    2.1.4 Canonical SMILES
    CC(C(C1=CC(=CC=C1)O)O)N.C(C(C(=O)O)O)(C(=O)O)O
    2.1.5 Isomeric SMILES
    C[C@@H]([C@@H](C1=CC(=CC=C1)O)O)N.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
    2.2 Other Identifiers
    2.2.1 UNII
    ZC4202M9P3
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Aramine

    2. Araminol

    3. Bitartrate, Metaraminol

    4. Hydroxyphenylpropanolamine

    5. Isophenylephrine

    6. M Hydroxynorephedrine

    7. M Hydroxyphenylpropanolamine

    8. M-hydroxynorephedrine

    9. M-hydroxyphenylpropanolamine

    10. Meta Hydroxynorephedrine

    11. Meta-hydroxynorephedrine

    12. Metaradrin

    13. Metaraminol

    14. Metaraminol Bitartrate (1:1)

    15. Metaraminol Tartrate

    16. Tartrate, Metaraminol

    2.3.2 Depositor-Supplied Synonyms

    1. 33402-03-8

    2. Metaraminol Tartrate

    3. Metaraminol (+)-bitartrate Salt

    4. Metaraminol (tartrate)

    5. (-)-metaraminol Bitartrate

    6. Metaradrine Tartrate

    7. Zc4202m9p3

    8. Nsc-758425

    9. Araminum

    10. Benzenemethanol, A-[(1s)-1-aminoethyl]-3-hydroxy-, (ar)-,(2r,3r)-2,3-dihydroxybutanedioate (1:1) (salt)

    11. Levicor

    12. Metaramin

    13. Levicor Ampullen

    14. Araminum Ampullen

    15. 3-[(1r,2s)-2-amino-1-hydroxypropyl]phenol;(2r,3r)-2,3-dihydroxybutanedioic Acid

    16. L-metraminol Bitartrate

    17. Metaradrine Bitartrate

    18. Aramine (sympathominetic)

    19. Metaraminol Tartrate (1:1)

    20. Unii-zc4202m9p3

    21. Ims Metaraminol Bitartrat Ampullen

    22. Metaraminol (r,r)-hydrogentartrat

    23. Metaraminol Bitartrate [usp:jan]

    24. Aramine (tn)

    25. Einecs 251-502-3

    26. Metaraminol Bitatrate

    27. Prestwick3_000197

    28. Metaraminol Bitartrate Salt

    29. (-)-m-hydroxyphenylpropanolamine Bitartrate Salt

    30. Schembl40982

    31. Bspbio_000153

    32. Bspbio_003506

    33. Bpbio1_000169

    34. 1-alpha-(1-aminoethyl)-m-hydroxybenzyl Alcohol Bitartrate

    35. (-)-alpha-(1-aminoethyl)-m-hydroxybenzyl Alcohol Bitartrate

    36. Hms2093a03

    37. Hms3885j21

    38. L-1-(m-hydroxyphenyl)-2-amino-1-propanol-d-hydrogen Tartrate

    39. Metaraminol Bitartrate (jan/usp)

    40. Pharmakon1600-01503251

    41. Metaraminol Bitartrate [mi]

    42. Ex-a1348

    43. Hy-b1116

    44. Metaraminol Bitartrate [jan]

    45. 1-alpha-(1-aminoethyl)-m-hydroxybenzyl Alcohol Hydrogen D-tartrate

    46. Metaraminol Tartrate [mart.]

    47. Nsc758425

    48. Metaraminol Bitartrate [vandf]

    49. Metaraminol Tartrate [who-dd]

    50. (-)-alpha-(1-aminoethyl)-m-hydroxybenzyl Alcohol Tartrate (1:1) (salt)

    51. Akos037515726

    52. Ccg-213141

    53. Cs-4715

    54. Metaraminol Bitartrate [usp-rs]

    55. Nsc 758425

    56. Benzyl Alcohol, Alpha-(1-aminoethyl)-m-hydroxy-, (-)-, Tartrate (1:1) (salt)

    57. Ac-33541

    58. Benzenemethanol, Alpha-(1-aminoethyl)-3-hydroxy-, (r-(r*,s*))-, (r-(r*,r*))-2,3-dihydroxybutanedioate (1:1) (salt)

    59. Bm166414

    60. Metaraminol Bitartrate [orange Book]

    61. Metaraminol Bitartrate (hydrogen L-tartrate)

    62. Metaraminol Bitartrate [usp Impurity]

    63. Metaraminol Bitartrate [usp Monograph]

    64. D01019

    65. F18205

    66. Metaraminol Bitartrate, (r-(r*,s*))-

    67. 402m038

    68. Sr-05000001611

    69. J-019180

    70. Sr-05000001611-1

    71. Q27107333

    72. Metaraminol Bitartrate, United States Pharmacopeia (usp) Reference Standard

    73. (-)-.alpha.-(1-aminoethyl)-m-hydroxybenzyl Alcohol Tartrate (1:1) (salt)

    74. 3-((1r,2s)-2-amino-1-hydroxypropyl)phenol (2r,3r)-2,3-dihydroxysuccinate

    75. Benzyl Alcohol, Alpha-(1-aminoethyl)-m-hydroxy-, Tartrate (1:1), D-(-)-

    76. Benzenemethanol, Alpha-((1s)-1-aminoethyl)-3-hydroxy-, (alphar)-, (2r,3r)-2,3-dihydroxybutanedioate (1:1)

    2.3.3 Other Synonyms

    1. (-)-metaraminol

    2. Hydroxynorephedrine

    3. L-metaraminol

    4. Metaradrine

    5. M-hydroxypropadrine

    6. Pressonex

    7. Metaraminol

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 317.29 g/mol
    Molecular Formula C13H19NO8
    Hydrogen Bond Donor Count7
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count5
    Exact Mass317.11106656 g/mol
    Monoisotopic Mass317.11106656 g/mol
    Topological Polar Surface Area182 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity274
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameMetaraminol bitartrate
    Active IngredientMetaraminol bitartrate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 10mg base/ml
    Market StatusPrescription
    CompanyFresenius Kabi Usa

    2 of 2  
    Drug NameMetaraminol bitartrate
    Active IngredientMetaraminol bitartrate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 10mg base/ml
    Market StatusPrescription
    CompanyFresenius Kabi Usa

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Sympathomimetics

    Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

    Vasoconstrictor Agents

    Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

    Adrenergic alpha-1 Receptor Agonists

    Compounds that bind to and activate ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Agonists.)