Please Wait
Applying Filters...
menu
    • menu
    DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

    Virtual Booth

    Contact Supplier

    Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    With Fermion, start the journey of your innovative API.

    Virtual Booth

    Contact Supplier

    Bloomage is a one-stop source for CEP Sodium Hyaluronate and Hyaluronic Acid// FDA-inspected & GMP-certified.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    Menu

    Methacholine Chloride

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    Xls

    Filters

    clear-filterReset all filters
    2D Structure
    Also known as: 62-51-1, Acetyl-beta-methylcholine chloride, Provocholine, Mecholyl chloride, Methacholine (chloride), Acetyl-2-methylcholine chloride
    Molecular Formula
    C8H18ClNO2
    Molecular Weight
    195.69  g/mol
    InChI Key
    JHPHVAVFUYTVCL-UHFFFAOYSA-M
    FDA UNII
    0W5ETF9M2K
    A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-acetyloxypropyl(trimethyl)azanium;chloride
    2.1.2 InChI
    InChI=1S/C8H18NO2.ClH/c1-7(11-8(2)10)6-9(3,4)5;/h7H,6H2,1-5H3;1H/q+1;/p-1
    2.1.3 InChI Key
    JHPHVAVFUYTVCL-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    CC(C[N+](C)(C)C)OC(=O)C.[Cl-]
    2.2 Other Identifiers
    2.2.1 UNII
    0W5ETF9M2K
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-(acetyloxy)-n,n,n-trimethyl-1-propanaminium Chloride

    2. Acetyl 2 Methylcholine Chloride

    3. Acetyl Beta Methacholine Chloride

    4. Acetyl Beta Methylcholine

    5. Acetyl-2-methylcholine Chloride

    6. Acetyl-beta-methacholine Chloride

    7. Acetyl-beta-methylcholine

    8. Chloride, Methacholine

    9. Mecholine

    10. Mecholyl

    11. Methacholine

    12. Provocholine

    13. Provokit

    2.3.2 Depositor-Supplied Synonyms

    1. 62-51-1

    2. Acetyl-beta-methylcholine Chloride

    3. Provocholine

    4. Mecholyl Chloride

    5. Methacholine (chloride)

    6. Acetyl-2-methylcholine Chloride

    7. 1-propanaminium, 2-(acetyloxy)-n,n,n-trimethyl-, Chloride

    8. (2-acetoxypropyl)trimethylammonium Chloride

    9. 2-acetyloxypropyl(trimethyl)azanium;chloride

    10. O-acetyl-beta-methylcholine Chloride

    11. Acetyl-

    12. A-methylcholine Chloride

    13. Nsc-757090

    14. 0w5etf9m2k

    15. Mls000069656

    16. Chebi:50142

    17. Amechol

    18. Mecholyl

    19. Provokit

    20. Smr000059224

    21. Dsstox_cid_3271

    22. Mecholine Chloride

    23. Dsstox_rid_76951

    24. Dsstox_gsid_23271

    25. 2-acetyloxy-n,n,n-trimethylpropan-1-aminium Chloride

    26. Methacholinium Chloride

    27. (+/-)-(2-hydroxypropyl)trimethylammonium Chloride Acetate

    28. Metacolina Cloruro

    29. Metacolina Cloruro [dcit]

    30. Cloruro De Metacolina

    31. Methacholini Chloridum

    32. Beta-methylacetylcholine Chloride

    33. Cloruro De Metacolina [spanish]

    34. Chlorure De Methacholine [french]

    35. Chlorure De Methacholine

    36. Sr-01000000215

    37. Methacholini Chloridum [inn-latin]

    38. Einecs 200-537-2

    39. Cloruro De Metacolina [inn-spanish]

    40. Dl-acetyl-beta-methylcholine Chloride

    41. Unii-0w5etf9m2k

    42. Chlorure De Methacholine [inn-french]

    43. (+-)-acetyl-beta-methylcholine Chloride

    44. Ai3-51680

    45. Trimethyl-beta-acetoxypropylammonium Chloride

    46. Prestwick_981

    47. Provocholine (tn)

    48. (2-hydroxypropyl)trimethylammonium Chloride Acetate

    49. Methacholine Chloride, Crystal, Usp

    50. Methacholine Chloride [usp:inn:ban]

    51. Cas-62-51-1

    52. Opera_id_1285

    53. Ncgc00016282-01

    54. Regid_for_cid_6114

    55. Schembl69104

    56. Mls001148375

    57. Spectrum1500391

    58. (+-)-(2-hydroxypropyl)trimethylammonium Chloride Acetate

    59. Chembl1200764

    60. Dtxsid7023271

    61. Acetyl-ss--methylcholine Chloride

    62. Hms1570g20

    63. Hms1920l11

    64. Hms2091d06

    65. Hms2097g20

    66. Hms2232b07

    67. Hms3260e11

    68. Hms3371l18

    69. Hms3714g20

    70. Hms3885a21

    71. Methacholine Chloride [mi]

    72. Pharmakon1600-01500391

    73. Methacholine Chloride [inn]

    74. Methacholine Chloride [jan]

    75. O-acetyl-

    76. A-methylcholine Chloride

    77. Ammonium, (2-hydroxypropyl)trimethyl-, Chloride, Acetate

    78. Hy-a0083

    79. Acetyl- Beta -methylcholine Chloride

    80. Tox21_110348

    81. Tox21_500025

    82. 1-propanaminium, 2-(acetyloxy)-n,n,n-trimethyl-, Chloride, (+-)-

    83. Ccg-39988

    84. Methacholine Chloride [vandf]

    85. Mfcd00011817

    86. Nsc757090

    87. Methacholine Chloride [mart.]

    88. Acetyl B-methylcholine Chloride 98%+

    89. Akos015892295

    90. Methacholine Chloride (jan/usp/inn)

    91. Methacholine Chloride [usp-rs]

    92. Methacholine Chloride [who-dd]

    93. Tox21_110348_1

    94. Fs-4023

    95. Lp00025

    96. Nsc 757090

    97. Ncgc00015045-09

    98. Ncgc00093548-01

    99. Ncgc00093548-02

    100. Ncgc00093548-03

    101. Ncgc00093548-04

    102. Ncgc00093548-05

    103. Ncgc00260710-01

    104. Methacholine Chloride [orange Book]

    105. Db-054187

    106. Eu-0100025

    107. Ft-0628268

    108. M0073

    109. Methacholine Chloride [usp Monograph]

    110. A 2251

    111. A-1480

    112. C75939

    113. D04970

    114. A833819

    115. 2-acetoxy-n,n,n-trimethylpropan-1-aminium Chloride

    116. Q-200715

    117. Sr-01000000215-2

    118. Sr-01000000215-4

    119. Sr-01000000215-7

    120. Q26841250

    121. 2-(acetyloxy)-n,n,n-trimethylpropan-1-aminium Chloride

    122. 1-propanaminium, 2-(acetyloxy)-n,n,n-trimethyl-, Chloride (1:1)

    123. 1-propanaminium, 2-(acetyloxy)-n,n,n-trimethyl-, Chloride, (+/-)-

    2.4 Create Date
    2005-06-29
    3 Chemical and Physical Properties
    Molecular Weight 195.69 g/mol
    Molecular Formula C8H18ClNO2
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count4
    Exact Mass195.1026065 g/mol
    Monoisotopic Mass195.1026065 g/mol
    Topological Polar Surface Area26.3 Ų
    Heavy Atom Count12
    Formal Charge0
    Complexity138
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameProvocholine
    PubMed HealthMethacholine (By breathing)
    Drug ClassesDiagnostic Agent, Bronchial
    Drug LabelProvocholine (methacholine chloride powder for inhalation) is a parasympathomimetic (cholinergic)) bronchoconstrictor agent to be administered in solution only, by inhalation, for diagnostic purposes. Each 20 mL vial contains 100 mg of methacholine...
    Active IngredientMethacholine chloride
    Dosage FormFor solution
    RouteInhalation
    Strength100mg/vial
    Market StatusPrescription
    CompanyMethapharm

    2 of 2  
    Drug NameProvocholine
    PubMed HealthMethacholine (By breathing)
    Drug ClassesDiagnostic Agent, Bronchial
    Drug LabelProvocholine (methacholine chloride powder for inhalation) is a parasympathomimetic (cholinergic)) bronchoconstrictor agent to be administered in solution only, by inhalation, for diagnostic purposes. Each 20 mL vial contains 100 mg of methacholine...
    Active IngredientMethacholine chloride
    Dosage FormFor solution
    RouteInhalation
    Strength100mg/vial
    Market StatusPrescription
    CompanyMethapharm

    4.2 Drug Indication

    Diagnosis of asthma

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Miotics

    Agents causing contraction of the pupil of the eye. Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here. (See all compounds classified as Miotics.)

    Muscarinic Agonists

    Drugs that bind to and activate muscarinic cholinergic receptors (RECEPTORS, MUSCARINIC). Muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the GI tract, urinary bladder and the eye. They may also be used to reduce heart rate. (See all compounds classified as Muscarinic Agonists.)

    Parasympathomimetics

    Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here. (See all compounds classified as Parasympathomimetics.)

    Bronchoconstrictor Agents

    Agents causing the narrowing of the lumen of a bronchus or bronchiole. (See all compounds classified as Bronchoconstrictor Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Cholinergic Receptor Agonist [EPC]; Cholinergic Agonists [MoA]