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    Methadone Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: Algolysin, Butalgin, Fenadone, Mecodin, Depridol, Dolophine
    Molecular Formula
    C21H28ClNO
    Molecular Weight
    345.9  g/mol
    InChI Key
    FJQXCDYVZAHXNS-UHFFFAOYSA-N
    FDA UNII
    229809935B
    A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    6-(dimethylamino)-4,4-diphenylheptan-3-one;hydrochloride
    2.1.2 InChI
    InChI=1S/C21H27NO.ClH/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19;/h6-15,17H,5,16H2,1-4H3;1H
    2.1.3 InChI Key
    FJQXCDYVZAHXNS-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    229809935B
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Amidone

    2. Biodone

    3. Dolophine

    4. Hydrochloride, Methadone

    5. Metadol

    6. Metasedin

    7. Methaddict

    8. Methadone

    9. Methadose

    10. Methex

    11. Phenadone

    12. Phymet

    13. Physeptone

    14. Pinadone

    15. Symoron

    2.3.2 Depositor-Supplied Synonyms

    1. Algolysin

    2. Butalgin

    3. Fenadone

    4. Mecodin

    5. Depridol

    6. Dolophine

    7. Methadose

    8. Moheptan

    9. Miadone

    10. Phenadone Hydrochloride

    11. Dolofin Hydrochloride

    12. 1095-90-5

    13. Methadone Hcl

    14. Ketalgin Hydrochloride

    15. Algidon

    16. Fenadon

    17. Heptadon

    18. Polamidon

    19. Adolan

    20. Adanon Hydrochloride

    21. Physeptone

    22. Diaminon Hydrochloride

    23. Dl-methadone Hydrochloride

    24. Dolophine Hydrochloride

    25. Dolohepton

    26. Westadone

    27. Althose Hydrochloride

    28. Mephenon

    29. Racemic Methadone Hydrochloride

    30. (+-)-methadone Hydrochloride

    31. Ccris 3320

    32. An-148

    33. Methadonium Chloride

    34. Dolophin Hydrochloride

    35. 4,4-diphenyl-6-dimethylamino-3-heptanone Hydrochloride

    36. Hoechst 10820

    37. 6-(dimethylamino)-4,4-diphenyl-3-heptanone Hydrochloride

    38. Dl-6-dimethylamino-4,4-diphenyl-3-heptanone Hydrochloride

    39. An 148

    40. Nsc-19600

    41. Methadone Hydrochloride Cii

    42. 3-heptanone, 6-(dimethylamino)-4,4-diphenyl-, Hydrochloride

    43. 6-(dimethylamino)-4,4-diphenylheptan-3-one Hydrochloride

    44. 125-56-4

    45. Chebi:50140

    46. 6-dimethylamino-4,4-diphenyl-3-heptanone.hcl

    47. Althose

    48. 6-(dimethylamino)-4,4-diphenylheptan-3-one;hydrochloride

    49. Tussal

    50. Dsstox_cid_501

    51. 3-heptanone, 6-(dimethylamino)-4,4-diphenyl-, Hydrochloride, (+-)-

    52. Diskets Dispersible

    53. Dsstox_rid_75626

    54. Dsstox_gsid_20501

    55. 229809935b

    56. (+-)-tussal

    57. (+/-)-methadone Hydrochloride

    58. Cas-1095-90-5

    59. Einecs 214-140-7

    60. Nsc 19600

    61. Methadose Oral Concentrate

    62. Methadose Sugar-free Oral

    63. Biscuits

    64. Dollies

    65. Macodin

    66. Medicine

    67. Dolly

    68. Methadone Hydrochloride [usp]

    69. Methadone Hydrochloride Intensol

    70. Tussol:

    71. Drg-0023

    72. Amidone Hydrochloride

    73. Unii-229809935b

    74. Azt + Methadone Hcl

    75. (+/-)-tussal

    76. (.+-.) Tussal

    77. Methadone Hydrochloride Dl-

    78. Dl-methadone, Hydrochloride

    79. Schembl24293

    80. Dolophine Hydrochloride (tn)

    81. Mls003922099

    82. 6-dimethylamino-4,4-diphenyl-3-heptanone Hydrochloride

    83. Chembl1200825

    84. Dtxsid2020501

    85. (.+-.)-methadone Hydrochloride

    86. Methadone Hydrochloride (jan/usp)

    87. 1,1-diphenyl-1-(2-dimethylaminopropyl)-2-butanone Hydrochloride

    88. Nsc19600

    89. Methadone Hydrochloride [mi]

    90. Tox21_112895

    91. Tox21_202026

    92. Tox21_300633

    93. Methadone Hydrochloride [jan]

    94. Methadone Hydrochloride [vandf]

    95. Methadone Hydrochloride [usp-rs]

    96. Methadone Hydrochloride [who-dd]

    97. Ncgc00254397-01

    98. Ncgc00259575-01

    99. Smr000058978

    100. Ft-0671040

    101. Methadone Hydrochloride [ep Impurity]

    102. Methadone Hydrochloride [orange Book]

    103. Methadone Hydrochloride Cii [usp-rs]

    104. Methadone Hydrochloride [ep Monograph]

    105. D02102

    106. Methadone Hydrochloride [usp Monograph]

    107. Wln: 2vxr & R & Y2 & N1 & 1

    108. 3-heptanone,4-diphenyl-, Hydrochloride,(.+-.)-

    109. 3-heptanone,4-diphenyl-, Hydrochloride, (.+-.)-

    110. Q26840915

    111. (+/-)-methadone Hydrochloride, Powder, >=98% (tlc)

    112. 3-heptanone, Dl-6-dimethylamino-4,4-diphenyl-, Hydrochloride

    113. 4,4-diphenyl-6-dimethylamino-3-heptanone Hydrochloride (+/-)-

    114. Dl-6-(dimethylamino)-4,4-diphenyl-3-heptanone Hydrochloride

    115. 4,4-diphenyl-6-(dimethylamino)-3-heptanone Hydrochloride(.+-.)-

    116. 6-(dimethylamino)-4,4-diphenyl-3-heptanone Hydrochloride (1:1)

    117. 3-heptanone, 6-(dimethylamino)-4,4-diphenyl-, Hydrochloride (1:1)

    118. 3-heptanone, 6-(dimethylamino)-4,4-diphenyl-, Hydrochloride (8ci,9ci)

    119. (+/-)-methadone Hydrochloride Solution, Drug Standard, 1.0 Mg/ml In Methanol

    2.4 Create Date
    2005-06-01
    3 Chemical and Physical Properties
    Molecular Weight 345.9 g/mol
    Molecular Formula C21H28ClNO
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count7
    Exact Mass345.1859422 g/mol
    Monoisotopic Mass345.1859422 g/mol
    Topological Polar Surface Area20.3 Ų
    Heavy Atom Count24
    Formal Charge0
    Complexity346
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 8  
    Drug NameDolophine hydrochloride
    Drug LabelDOLOPHINE HYDROCHLORIDE (Methadone Hydrochloride Tablets, USP), for oral administration, each contain 5 mg or 10 mg of methadone hydrochloride.Methadone hydrochloride is a white, crystalline material that is water-soluble. Methadone hydrochloride i...
    Active IngredientMethadone hydrochloride
    Dosage FormInjectable; Tablet
    RouteInjection; Oral
    Strength5mg; 10mg; 10mg/ml
    Market StatusPrescription
    CompanyMylan Institutional; Roxane

    2 of 8  
    Drug NameMethadone hydrochloride
    Drug LabelDESCRIPTIONMethadone Hydrochloride Tablets USP for oral administration, each contain 5 mg or 10 mg of methadone hydrochloride.Methadone hydrochloride is a white, crystalline material that is water-soluble.Methadone hydrochloride is chemically describ...
    Active IngredientMethadone hydrochloride
    Dosage FormTablet, for suspension; Tablet; Concentrate; Powder; Solution
    RouteOral; For rx compounding
    Strength10mg/5ml; 50gm/bot; 500gm/bot; 10mg/ml; 5mg; 10mg; 100gm/bot; 5mg/5ml; 40mg
    Market StatusPrescription
    CompanyThe Pharmanetwork; Mallinckrodt; Sandoz; Roxane; Vistapharm

    3 of 8  
    Drug NameMethadone hydrochloride intensol
    Active IngredientMethadone hydrochloride
    Dosage FormConcentrate
    RouteOral
    Strength10mg/ml
    Market StatusPrescription
    CompanyRoxane

    4 of 8  
    Drug NameMethadose
    Drug LabelMethadose Oral Concentrate (methadone hydrochloride oral concentrate USP) is supplied as a cherry flavored liquid concentrate. Methadose Sugar-Free Oral Concentrate (methadone hydrochloride oral concentrate USP) is a dye-free, sugar-free, unfla...
    Active IngredientMethadone hydrochloride
    Dosage FormTablet, for suspension; Tablet; Concentrate
    RouteOral
    Strength10mg/ml; 5mg; 10mg; 40mg
    Market StatusPrescription
    CompanyMallinckrodt

    5 of 8  
    Drug NameDolophine hydrochloride
    Drug LabelDOLOPHINE HYDROCHLORIDE (Methadone Hydrochloride Tablets, USP), for oral administration, each contain 5 mg or 10 mg of methadone hydrochloride.Methadone hydrochloride is a white, crystalline material that is water-soluble. Methadone hydrochloride i...
    Active IngredientMethadone hydrochloride
    Dosage FormInjectable; Tablet
    RouteInjection; Oral
    Strength5mg; 10mg; 10mg/ml
    Market StatusPrescription
    CompanyMylan Institutional; Roxane

    6 of 8  
    Drug NameMethadone hydrochloride
    Drug LabelDESCRIPTIONMethadone Hydrochloride Tablets USP for oral administration, each contain 5 mg or 10 mg of methadone hydrochloride.Methadone hydrochloride is a white, crystalline material that is water-soluble.Methadone hydrochloride is chemically describ...
    Active IngredientMethadone hydrochloride
    Dosage FormTablet, for suspension; Tablet; Concentrate; Powder; Solution
    RouteOral; For rx compounding
    Strength10mg/5ml; 50gm/bot; 500gm/bot; 10mg/ml; 5mg; 10mg; 100gm/bot; 5mg/5ml; 40mg
    Market StatusPrescription
    CompanyThe Pharmanetwork; Mallinckrodt; Sandoz; Roxane; Vistapharm

    7 of 8  
    Drug NameMethadone hydrochloride intensol
    Active IngredientMethadone hydrochloride
    Dosage FormConcentrate
    RouteOral
    Strength10mg/ml
    Market StatusPrescription
    CompanyRoxane

    8 of 8  
    Drug NameMethadose
    Drug LabelMethadose Oral Concentrate (methadone hydrochloride oral concentrate USP) is supplied as a cherry flavored liquid concentrate. Methadose Sugar-Free Oral Concentrate (methadone hydrochloride oral concentrate USP) is a dye-free, sugar-free, unfla...
    Active IngredientMethadone hydrochloride
    Dosage FormTablet, for suspension; Tablet; Concentrate
    RouteOral
    Strength10mg/ml; 5mg; 10mg; 40mg
    Market StatusPrescription
    CompanyMallinckrodt

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antitussive Agents

    Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally. (See all compounds classified as Antitussive Agents.)

    Narcotics

    Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS. (See all compounds classified as Narcotics.)

    Analgesics, Opioid

    Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Opioid Agonist [EPC]; Full Opioid Agonists [MoA]