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    Methadyl Acetate

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    2D Structure
    Also known as: Acetylmethadol, 509-74-0, Acetilmetadol [inn-spanish], Acetylmethadolum [inn-latin], Methadyl acetate [usan], 3-acetoxy-6-dimethylamino-4,4-diphenylheptane
    Molecular Formula
    C23H31NO2
    Molecular Weight
    353.5  g/mol
    InChI Key
    XBMIVRRWGCYBTQ-UHFFFAOYSA-N
    FDA UNII
    L59OC40KWJ
    A narcotic analgesic with a long onset and duration of action.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [6-(dimethylamino)-4,4-diphenylheptan-3-yl] acetate
    2.1.2 InChI
    InChI=1S/C23H31NO2/c1-6-22(26-19(3)25)23(17-18(2)24(4)5,20-13-9-7-10-14-20)21-15-11-8-12-16-21/h7-16,18,22H,6,17H2,1-5H3
    2.1.3 InChI Key
    XBMIVRRWGCYBTQ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCC(C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2)OC(=O)C
    2.2 Other Identifiers
    2.2.1 UNII
    L59OC40KWJ
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (3r,6r)-3-acetoxy-6-dimethylamino-4,4-diphenylheptane

    2. 6-(dimethylamino)-4,4-diphenyl-3-heptanol Acetate

    3. Acemethadone

    4. Acetylmethadol

    5. Alphacetylmethadol

    6. Amidolacetate

    7. Dimepheptanol

    8. Laam

    9. Levo Alpha Acetylmethadol

    10. Levo-alpha-acetylmethadol

    11. Levoacetylmethadol

    12. Levomethadyl

    13. Levomethadyl Acetate

    14. Levomethadyl Acetate Hydrochloride

    15. Methadol

    16. Orlaam

    2.3.2 Depositor-Supplied Synonyms

    1. Acetylmethadol

    2. 509-74-0

    3. Acetilmetadol [inn-spanish]

    4. Acetylmethadolum [inn-latin]

    5. Methadyl Acetate [usan]

    6. 3-acetoxy-6-dimethylamino-4,4-diphenylheptane

    7. Acetylmethadol (inn)

    8. Acetylmethadol [inn]

    9. [6-(dimethylamino)-4,4-diphenylheptan-3-yl] Acetate

    10. 6-(dimethylamino)-4,4-diphenyl-3-heptanol Acetate (ester)

    11. Acemethadone

    12. Methadyl Acetate (usan)

    13. L59oc40kwj

    14. Acscn-9601

    15. Chembl170179

    16. Ids-na-004

    17. Nih-2953

    18. Race-acetylmethadol

    19. Acetilmetadol

    20. Acetylmethadolum

    21. Levomethadyl

    22. Einecs 208-103-4

    23. 1-ethyl-4-dimethylamino-2,2-diphenylpentylacetat

    24. Unii-l59oc40kwj

    25. (r,s)-4-dimethylamino-1-ethyl-2,2-diphenylpentyl Acetat

    26. Dea No. 9601

    27. Benzeneethanol, Beta-(2-(dimethylamino)propyl)-alpha-ethyl-beta-phenyl-, Acetate (ester)

    28. Orlaam (salt/mix)

    29. L-.alpha.-acetylmethadol

    30. Levo-.alpha.-acetylmethadol

    31. Mk 790 (salt/mix)

    32. (-)-.alpha.-acetylmethadol

    33. Methadyl Acetate [mi]

    34. Schembl119911

    35. 4-(dimethylamino)-1-ethyl-2,2-diphenylpentyl Acetate

    36. Dtxsid2023274

    37. 3-heptanol, 6-(dimethylamino)-4,4-diphenyl-, Acetate (ester), (3s,6s)-(-)-

    38. Chebi:135491

    39. Bdbm50027391

    40. Db01433

    41. Levomethadyl Acetate Hydrochloride (salt/mix)

    42. D04973

    43. L000758

    44. Q4673310

    45. O-acetyl-6-dimethylamino-4,4-diphenyl-3-heptanol

    46. Acetic Acid 4-dimethylamino-1-ethyl-2,2-diphenyl-pentyl Ester

    47. 4-(dimethylamino)-1-ethyl-2,2-diphenylpentyl Acetate, (3s,6s)-(-)-

    48. Acetic Acid (1s,4s)-4-dimethylamino-1-ethyl-2,2-diphenyl-pentyl Ester

    49. Benzeneethanol, .beta.-((2s)-2-(dimethylamino)propyl)-.alpha.-ethyl-.beta.-phenyl-, Acetate (ester), (.alpha.s)-

    50. Benzeneethanol, .beta.-(2-(dimethylamino)propyl)-.alpha.-ethyl-.beta.-phenyl-, Acetate (ester)

    51. Benzeneethanol, .beta.-[2-(dimethylamino)propyl]-.alpha.-ethyl-.beta.-phenyl-, Acetate (ester), [s-(r*,r*)]-

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 353.5 g/mol
    Molecular Formula C23H31NO2
    XLogP34.3
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count9
    Exact Mass353.235479232 g/mol
    Monoisotopic Mass353.235479232 g/mol
    Topological Polar Surface Area29.5 Ų
    Heavy Atom Count26
    Formal Charge0
    Complexity404
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Used mainly in the treatment of narcotic dependence.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Methadyl Acetate is a narcotic analgesic with a long onset and duration of action. The drug decreases a patients opioid use by preventing opioid withdrawal and in how it can mimic some of the effects of opioids.

    5.2 MeSH Pharmacological Classification

    Analgesics, Opioid

    Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)

    5.3 Mechanism of Action

    Methadyl Acetate is primarily a mu-type opioid receptor agonist. It functions similarily to methadone.