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2D Structure
Also known as: Medronic acid, 1984-15-2, Phosphonic acid, methylenebis-, Phosphonomethylphosphonic acid, Medronate, Methanediphosphonic acid
Molecular Formula
CH6O6P2
Molecular Weight
176.00  g/mol
InChI Key
MBKDYNNUVRNNRF-UHFFFAOYSA-N
FDA UNII
73OS0QIN3O

Medronic Acid is a methylene-substituted bisphosphonate. Medronic acid has affinity for and adheres to the surface of hydroxyapatite crystals in the bone matrix. This agent accumulates at sites of osteoid mineralization and can be used, complexed with radioisotopes such as technetium 99m, in bone imaging.
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
phosphonomethylphosphonic acid
2.1.2 InChI
InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7)
2.1.3 InChI Key
MBKDYNNUVRNNRF-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C(P(=O)(O)O)P(=O)(O)O
2.2 Other Identifiers
2.2.1 UNII
73OS0QIN3O
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Disodium Methanediphosphonate

2. Methane Diphosphonate

3. Methylene Diphosphonate

4. Methylene Diphosphonate, (32)p-labeled

5. Methylene Diphosphonate, Disodium Salt

6. Methylene Diphosphonate, Tetrasodium Salt

7. Methylene Diphosphonate, Tetrasodium Salt, (32)p-labeled

8. Methylene Diphosphonate, Tin(4+) Salt, (113)sn-labeled

9. Methylene Diphosphonate, Trisodium Salt

10. Methylene Diphosphonic Acid

2.3.2 Depositor-Supplied Synonyms

1. Medronic Acid

2. 1984-15-2

3. Phosphonic Acid, Methylenebis-

4. Phosphonomethylphosphonic Acid

5. Medronate

6. Methanediphosphonic Acid

7. Acido Medronico

8. Acide Medronique

9. Acidum Medronicum

10. Methylene Diphosphonic Acid

11. Methylenebis(phosphonic Acid)

12. Mdp-bracco

13. Methanediylbis(phosphonic Acid)

14. Methanebisphosphonic Acid

15. Methylene-1,1-bisphosphonic Acid

16. Einecs 217-851-0

17. Phosphonic Acid, Methylenedi-

18. 73os0qin3o

19. Mls000048571

20. Chembl180570

21. (phosphonomethyl)phosphonic Acid

22. Chebi:43945

23. Medronic Acid (usan)

24. Smr000060476

25. Medronic Acid [usan]

26. Mdn

27. Acide Medronique [inn-french]

28. Acido Medronico [inn-spanish]

29. Acidum Medronicum [inn-latin]

30. Unii-73os0qin3o

31. Medronic-acid

32. Medronic Acid [usan:inn:ban]

33. Methylene Diphsphonate

34. Methandiphosphonic Acid

35. Opera_id_703

36. Medronic Acid [ii]

37. Medronic Acid [mi]

38. Dsstox_cid_25696

39. Dsstox_rid_81068

40. Medronic Acid [inn]

41. Dsstox_gsid_45696

42. Schembl66716

43. Methylene Bis-phosphonic Acid

44. Mdp, Methanediphosphonic Acid

45. Bis(dihydroxyphosphoryl)methane

46. Phosphonomethyl-phosphonic Acid

47. Medronic Acid [mart.]

48. Medronic Acid [who-dd]

49. Dtxsid8045696

50. Mbkdynnuvrnnrf-uhfffaoysa-

51. Amy31948

52. Bcp20495

53. Methylenediphosphonic Acid, >=99%

54. Zinc8015016

55. Tox21_110974

56. Bdbm50162816

57. Mfcd00002139

58. Phosphonic Acid, P,p'-methylenebis-

59. Stl302043

60. Akos001031749

61. Db14078

62. Ncgc00037856-01

63. Ncgc00037856-02

64. Cas-1984-15-2

65. Methylene Diphosphonic Acid [vandf]

66. Db-009770

67. Hy-108309

68. Cs-0028208

69. Ft-0628882

70. M0843

71. D04887

72. Diethylenetriaminepentakis(methylphosphonic Acid)

73. T72027

74. A928713

75. Methylenediphosphonic Acidmethylenediphosphonic Acid

76. Q2823283

77. Medronic Acid, European Pharmacopoeia (ep) Reference Standard

78. Methylenediphosphonic Acid, For Molecular Studies & Mass Spectrometry

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 176.00 g/mol
Molecular Formula CH6O6P2
XLogP3-3.3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass175.96396190 g/mol
Monoisotopic Mass175.96396190 g/mol
Topological Polar Surface Area115 Ų
Heavy Atom Count9
Formal Charge0
Complexity152
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameMdp-bracco
Active IngredientTechnetium tc-99m medronate kit
Dosage FormInjectable
RouteInjection
Strengthn/a
Market StatusPrescription
CompanyBracco

2 of 2  
Drug NameMdp-bracco
Active IngredientTechnetium tc-99m medronate kit
Dosage FormInjectable
RouteInjection
Strengthn/a
Market StatusPrescription
CompanyBracco

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Bone Density Conservation Agents

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)