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    Methylprednisolone Hemisuccinate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 1,859Xls

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    2D Structure
    Also known as: 2921-57-5, Methylprednisolone succinate, Methylprednisolone hydrogen succinate, Methylprednisolone hydrogen hemisuccinate, Methylprednisolone hemisuccinate [usp], 4-[2-[(6s,8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid
    Molecular Formula
    C26H34O8
    Molecular Weight
    474.5  g/mol
    InChI Key
    IMBXEJJVJRTNOW-XYMSELFBSA-N
    FDA UNII
    5GMR90S4KN
    A water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-[2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid
    2.1.2 InChI
    InChI=1S/C26H34O8/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31)/t14-,16-,17-,19-,23+,24-,25-,26-/m0/s1
    2.1.3 InChI Key
    IMBXEJJVJRTNOW-XYMSELFBSA-N
    2.1.4 Canonical SMILES
    CC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)CCC(=O)O)O
    2.1.5 Isomeric SMILES
    C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)CCC(=O)O)O
    2.2 Other Identifiers
    2.2.1 UNII
    5GMR90S4KN
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 6 Alpha-methylprednisolone Sodium Hemisuccinate

    2. A-methapred

    3. Hemisuccinate, Methylprednisolone

    4. Methylprednisolone Hemisuccinate Monosodium Salt

    5. Methylprednisolone Sodium Hemisuccinate

    6. Methylprednisolone Sodium Succinate

    7. Methylprednisolone Succinate

    8. Sodium Hemisuccinate, Methylprednisolone

    9. Sodium Succinate, Methylprednisolone

    10. Solu-medrol

    11. Solumedrol

    12. Succinate, Methylprednisolone

    13. Urbason-soluble

    14. Urbasonsoluble

    2.3.2 Depositor-Supplied Synonyms

    1. 2921-57-5

    2. Methylprednisolone Succinate

    3. Methylprednisolone Hydrogen Succinate

    4. Methylprednisolone Hydrogen Hemisuccinate

    5. Methylprednisolone Hemisuccinate [usp]

    6. 4-[2-[(6s,8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic Acid

    7. 5gmr90s4kn

    8. 6alpha-methylprednisolone Hemisuccinate

    9. 6alpha-methylprednisolone 21-hemisuccinate

    10. Methylprednisolone Hemisuccinate (usp)

    11. Ncgc00185763-01

    12. Einecs 220-863-9

    13. Unii-5gmr90s4kn

    14. Ec 220-863-9

    15. Schembl7915

    16. 11beta,17,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-(hydrogen Succinate)

    17. Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, (6alpha,11beta)-

    18. Methylpredinisolone Hemisuccinate

    19. Chembl1201265

    20. Dtxsid80183466

    21. 6-methylprednisolone Hemisuccinate

    22. Chebi:135765

    23. Methylprednisolone-sodium-succinate

    24. Hy-b1900

    25. Zinc3977781

    26. Methylprednisolone Succinate (jp17)

    27. S6588

    28. 6-methylprednisolone-21-hemisuccinate

    29. Akos015894899

    30. Cs-8183

    31. Db14644

    32. Ncgc00185763-03

    33. As-76484

    34. Methylprednisolone Succinate [jan]

    35. D05000

    36. D97631

    37. Methylprednisolone Hemisuccinate [usp-rs]

    38. Methylprednisolone Hemisuccinate [who-dd]

    39. 921m575

    40. A819819

    41. Methylprednisolone Hydrogen Succinate [mart.]

    42. Methylprednisolone Hemisuccinate [usp Impurity]

    43. Q27262132

    44. Methylprednisolone Hemisuccinate [usp Monograph]

    45. Methylprednisolone Hydrogen Succinate For Performance Test

    46. Methylprednisolone Hydrogen Succinate For Peak Identification

    47. 11beta,17,21-trihydroxy-6alpha-methyl-3,20-dioxopregna-1,4-dien-21-yl 3-carboxypropionate

    48. 11beta,17,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-succinate

    49. 4-(2-((6s,8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxy)-4-oxobutanoic Acid

    50. 4-[2-[(6s,8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethoxy]-4-oxo-butanoic Acid

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 474.5 g/mol
    Molecular Formula C26H34O8
    XLogP32.2
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count7
    Exact Mass474.22536804 g/mol
    Monoisotopic Mass474.22536804 g/mol
    Topological Polar Surface Area138 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity981
    Isotope Atom Count0
    Defined Atom Stereocenter Count8
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameMethylprednisolone sodium succinate
    Drug LabelSOLU-MEDROL Sterile Powder is an antiflammatory glucocorticoid, which contains methylprednisolone sodium succinate as the active ingredient. Methylprednisolone sodium succinate, USP, is the sodium succinate ester of methylprednisolone, and it occurs...
    Active IngredientMethylprednisolone sodium succinate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 2gm base/vial; eq 40mg base/vial; eq 125mg base/vial; eq 500mg base/vial; eq 1gm base/vial
    Market StatusPrescription
    CompanyMustafa Nevsat; Fresenius Kabi Usa

    2 of 2  
    Drug NameMethylprednisolone sodium succinate
    Drug LabelSOLU-MEDROL Sterile Powder is an antiflammatory glucocorticoid, which contains methylprednisolone sodium succinate as the active ingredient. Methylprednisolone sodium succinate, USP, is the sodium succinate ester of methylprednisolone, and it occurs...
    Active IngredientMethylprednisolone sodium succinate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 2gm base/vial; eq 40mg base/vial; eq 125mg base/vial; eq 500mg base/vial; eq 1gm base/vial
    Market StatusPrescription
    CompanyMustafa Nevsat; Fresenius Kabi Usa

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Methylprednisolone sodium succinate (the sodium salt of methylprednisolone hemisuccinate) has the same metabolic and anti-inflammatory actions as methylprednisolone. When given parenterally and in equimolar quantities, the two compounds are equivalent in biologic activity.

    5.2 MeSH Pharmacological Classification

    Antineoplastic Agents, Hormonal

    Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079) (See all compounds classified as Antineoplastic Agents, Hormonal.)

    Anti-Inflammatory Agents

    Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

    Neuroprotective Agents

    Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)

    Glucocorticoids

    A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)