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    Migalastat Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: Migalastat hcl, 75172-81-5, Deoxygalactonojirimycin hydrochloride, Galafold, 1-deoxygalactonojirimycin hydrochloride, Amigal
    Molecular Formula
    C6H14ClNO4
    Molecular Weight
    199.63  g/mol
    InChI Key
    ZJIHMALTJRDNQI-OLALXQGDSA-N
    FDA UNII
    CLY7M0XD20
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol;hydrochloride
    2.1.2 InChI
    InChI=1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4+,5+,6-;/m1./s1
    2.1.3 InChI Key
    ZJIHMALTJRDNQI-OLALXQGDSA-N
    2.1.4 Canonical SMILES
    C1C(C(C(C(N1)CO)O)O)O.Cl
    2.1.5 Isomeric SMILES
    C1[C@@H]([C@H]([C@H]([C@H](N1)CO)O)O)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    CLY7M0XD20
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1-butyl-2-(hydroxylmethyl)piperidine-3,4,5-triol

    2. 1-deoxy-galactonojirimycin

    3. 1-deoxygalacto-nojirimycin

    4. 1-deoxygalactonojirimycin

    5. At1001 Deoxyjirimycin

    6. Galafold

    7. Gr181413a

    8. Lucerastat

    9. Migalastat

    10. Migalastat Hcl

    11. N-butyldeoxygalacto-nojirimycin

    12. N-butyldeoxygalactonojirimycin

    13. Nb-dgj

    2.3.2 Depositor-Supplied Synonyms

    1. Migalastat Hcl

    2. 75172-81-5

    3. Deoxygalactonojirimycin Hydrochloride

    4. Galafold

    5. 1-deoxygalactonojirimycin Hydrochloride

    6. Amigal

    7. Migalastat Hydrochloride [usan]

    8. Migalastat (hydrochloride)

    9. Cly7m0xd20

    10. 75172-81-5 (hcl)

    11. At-1001 (migalastat Hydrochloride)

    12. (2r,3s,4r,5s)-2-(hydroxymethyl)piperidine-3,4,5-triol Hydrochloride

    13. (2r,3s,4r,5s)-2-(hydroxymethyl)piperidine-3,4,5-triol Hydrochloride.

    14. Gr181413a

    15. Unii-cly7m0xd20

    16. Migalastathcl

    17. Galafold (tn)

    18. Deoxygalactonojirimycin,hydrochloride

    19. Deoxygalactonojirimycin, Hydrochloride

    20. 1-deoxygalactonojirimycin Hcl

    21. Schembl3802618

    22. Chembl2107355

    23. Dtxsid801026249

    24. (+)-migalastat Hydrochloride

    25. Hy-14929a

    26. Mfcd00269962

    27. Migalastat Hydrochloride (jan/usan)

    28. Migalastat Hydrochloride [mi]

    29. Migalastat Hydrochloride [jan]

    30. 3,4,5-piperidinetriol, 2-(hydroxymethyl)-, Hydrochloride, (2r,3s,4r,5s)-

    31. At13690

    32. Cs-6380

    33. Migalastat Hydrochloride [who-dd]

    34. Migalastat Hydrochloride [orange Book]

    35. D05031

    36. 1,5-dideoxy-1,5-imino-d-galactitol Hydrochloride

    37. W-203722

    38. Q27275527

    39. (+)-(2r,3s,4r,5s)-2-(hydroxymethyl)piperidine-3,4,5-triol Hydrochloride

    40. (2r,3s,4r,5s)-2-(hydroxymethyl)-3,4,5-piperidinetriol Hydrochloride

    41. (2r,3s,4r,5s)-2-(hydroxymethyl)piperidine-3,4,5-triol;hydrochloride

    42. 3,4,5-piperidinetriol, 2-(hydroxymethyl)-, Hydrochloride (1:1), (2r,3s,4r,5s)-

    43. 3,4,5-piperidinetriol, 2-(hydroxymethyl)-, Hydrochloride,[2r-(2a,3a,4a,5b)]-

    2.4 Create Date
    2006-10-26
    3 Chemical and Physical Properties
    Molecular Weight 199.63 g/mol
    Molecular Formula C6H14ClNO4
    Hydrogen Bond Donor Count6
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count1
    Exact Mass199.0611356 g/mol
    Monoisotopic Mass199.0611356 g/mol
    Topological Polar Surface Area93 Ų
    Heavy Atom Count12
    Formal Charge0
    Complexity132
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Indication

    Galafold is indicated for long-term treatment of adults and adolescents aged 16 years and older with a confirmed diagnosis of Fabry disease (-galactosidase A deficiency) and who have an amenable mutation.

    5 Pharmacology and Biochemistry
    5.1 ATC Code

    A16AX