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    Milnacipran

    ACTIVE PHARMA INGREDIENTS

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    ANALYTICAL

    PharmaCompass
    $ API Ref.Price (USD/KG) : 936Xls

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    2D Structure
    Also known as: 92623-85-3, Dextromilnacipran, Levomilnacipran, 96847-55-1, Milnacipranum [latin], Toledomin
    Molecular Formula
    C15H22N2O
    Molecular Weight
    246.35  g/mol
    InChI Key
    GJJFMKBJSRMPLA-HIFRSBDPSA-N
    FDA UNII
    G56VK1HF36
    A cyclopropanecarboxamide serotonin and norepinephrine reuptake inhibitor (SNRI) that is used in the treatment of FIBROMYALGIA.
    Milnacipran is a Serotonin and Norepinephrine Reuptake Inhibitor. The mechanism of action of milnacipran is as a Norepinephrine Uptake Inhibitor, and Serotonin Uptake Inhibitor.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide
    2.1.2 InChI
    InChI=1S/C15H22N2O/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12/h5-9,13H,3-4,10-11,16H2,1-2H3/t13-,15+/m1/s1
    2.1.3 InChI Key
    GJJFMKBJSRMPLA-HIFRSBDPSA-N
    2.1.4 Canonical SMILES
    CCN(CC)C(=O)C1(CC1CN)C2=CC=CC=C2
    2.1.5 Isomeric SMILES
    CCN(CC)C(=O)[C@@]1(C[C@@H]1CN)C2=CC=CC=C2
    2.2 Other Identifiers
    2.2.1 UNII
    G56VK1HF36
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1 Phenyl 1 Diethylaminocarbonyl 2 Aminomethylcyclopropane Hcl

    2. 1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane Hcl

    3. F 2207

    4. F-2207

    5. F2207

    6. Ixel

    7. Midalcipran

    8. Milnacipran Hydrochloride

    9. Savella

    2.3.2 Depositor-Supplied Synonyms

    1. 92623-85-3

    2. Dextromilnacipran

    3. Levomilnacipran

    4. 96847-55-1

    5. Milnacipranum [latin]

    6. Toledomin

    7. Milnacipran [inn]

    8. Ixel

    9. (1r,2s)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropane-1-carboxamide

    10. Es1o38j3c4

    11. G56vk1hf36

    12. F2696

    13. Milnacipran (inn)

    14. (+-)-milnacipran

    15. (1r,2s)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide

    16. Impulsor

    17. F2207

    18. Milnacipranum

    19. Milnace

    20. (1r,2s)-2-(aminomethyl)-n,n-diethyl-1-phenyl-cyclopropane-1-carboxamide

    21. Cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-,(1r,2s)-rel-

    22. (-)-milnacipran

    23. Milnacipran [inn:ban]

    24. Unii-es1o38j3c4

    25. Unii-g56vk1hf36

    26. (?)-milnacipran

    27. Milnacipran [mi]

    28. Cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-, Cis-(+-)-

    29. Milnacipran [vandf]

    30. Schembl8099

    31. Milnacipran [who-dd]

    32. (1r,2s)-milnacipran

    33. Milnacipran [ema Epar]

    34. Chembl252923

    35. Dtxsid3048287

    36. Bdbm86420

    37. Chebi:94468

    38. Zinc14037

    39. Dtxsid601025164

    40. Hy-b0168

    41. (+-)-cis-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide

    42. Ncgc00165825-01

    43. Hy-14794

    44. Milnacipran Pierre Fabre Medicament

    45. Cas_92623-85-3

    46. Cs-0003566

    47. C16729

    48. D08222

    49. F-2696

    50. Ab00640027_06

    51. 623m853

    52. Q421058

    53. (1rs,2sr)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide

    54. Cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-, (1r,2s)-

    55. Cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-, (1r,2s)-rel-

    56. Cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-, (1r-cis)-

    57. F0f

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 246.35 g/mol
    Molecular Formula C15H22N2O
    XLogP31.4
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count5
    Exact Mass246.173213330 g/mol
    Monoisotopic Mass246.173213330 g/mol
    Topological Polar Surface Area46.3 Ų
    Heavy Atom Count18
    Formal Charge0
    Complexity295
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameSavella
    PubMed HealthMilnacipran (By mouth)
    Drug ClassesCentral Nervous System Agent
    Drug LabelMilnacipran hydrochloride is a selective norepinephrine and serotonin reuptake inhibitor; it inhibits norepinephrine uptake with greater potency than serotonin. It is a racemic mixture with the chemical name: ()-[1R(S),2S(R)]-2-(aminomethyl)-N,N-di...
    Active IngredientMilnacipran hydrochloride
    Dosage FormTablet
    RouteOral
    Strength25mg; 100mg; 50mg; 12.5mg
    Market StatusPrescription
    CompanyCypress Bioscience

    2 of 2  
    Drug NameSavella
    PubMed HealthMilnacipran (By mouth)
    Drug ClassesCentral Nervous System Agent
    Drug LabelMilnacipran hydrochloride is a selective norepinephrine and serotonin reuptake inhibitor; it inhibits norepinephrine uptake with greater potency than serotonin. It is a racemic mixture with the chemical name: ()-[1R(S),2S(R)]-2-(aminomethyl)-N,N-di...
    Active IngredientMilnacipran hydrochloride
    Dosage FormTablet
    RouteOral
    Strength25mg; 100mg; 50mg; 12.5mg
    Market StatusPrescription
    CompanyCypress Bioscience

    4.2 Drug Indication

    Treatment of stroke

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Analgesics, Non-Narcotic

    A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)

    Serotonin and Noradrenaline Reuptake Inhibitors

    Drugs that selectively block or suppress the plasma membrane transport of SEROTONIN and NORADRENALINE into axon terminals and are used as ANTIDEPRESSIVE AGENTS. (See all compounds classified as Serotonin and Noradrenaline Reuptake Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Active Moiety
    MILNACIPRAN
    5.2.2 FDA UNII
    G56VK1HF36
    5.2.3 Pharmacological Classes
    Serotonin Uptake Inhibitors [MoA]; Serotonin and Norepinephrine Reuptake Inhibitor [EPC]; Norepinephrine Uptake Inhibitors [MoA]
    5.3 ATC Code

    N06AX17

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    N - Nervous system

    N06 - Psychoanaleptics

    N06A - Antidepressants

    N06AX - Other antidepressants

    N06AX17 - Milnacipran

    N - Nervous system

    N06 - Psychoanaleptics

    N06A - Antidepressants

    N06AX - Other antidepressants

    N06AX28 - Levomilnacipran