Also known as: 1313881-70-7, Arq-092, Akt inhibitor 2, Arq 092 free base, Arq 092, Miransertib [inn]

Molecular Formula

C₂₇H₂₄N₆

Molecular Weight

432.5 g/mol

InChI Key

HNFMVVHMKGFCMB-UHFFFAOYSA-N

FDA UNII

T1DQI1B52Y

Miransertib is an orally bioavailable inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. Miransertib binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. This may lead to the reduction in tumor cell proliferation and the induction of tumor cell apoptosis. The AKT signaling pathway is often deregulated in cancer and is associated with tumor cell proliferation, survival and migration.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenylimidazo[4,5-b]pyridin-2-yl]pyridin-2-amine

2.1.2 InChI

InChI=1S/C27H24N6/c28-24-21(8-4-17-30-24)25-32-23-14-13-22(18-6-2-1-3-7-18)31-26(23)33(25)20-11-9-19(10-12-20)27(29)15-5-16-27/h1-4,6-14,17H,5,15-16,29H2,(H2,28,30)

2.1.3 InChI Key

HNFMVVHMKGFCMB-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CC(C1)(C2=CC=C(C=C2)N3C4=C(C=CC(=N4)C5=CC=CC=C5)N=C3C6=C(N=CC=C6)N)N

2.2 Other Identifiers

2.2.1 UNII

T1DQI1B52Y

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3h-imidazo(4,5-b)pyridin-2-yl)pyridin-2-amine

2. Arq 092

2.3.2 Depositor-Supplied Synonyms

1. 1313881-70-7

2. Arq-092

3. Akt Inhibitor 2

4. Arq 092 Free Base

5. Arq 092

6. Miransertib [inn]

7. Arq092

8. Miransertib [usan]

9. Miransertib [who-dd]

10. T1dqi1b52y

11. 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenylimidazo[4,5-b]pyridin-2-yl]pyridin-2-amine

12. 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3h-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine

13. 3-[3-[4-(1-azanylcyclobutyl)phenyl]-5-phenyl-imidazo[4,5-b]pyridin-2-yl]pyridin-2-amine

14. 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3h-imidazo(4,5-b)pyridin-2-yl)-2-pyridinamine

15. 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3h-imidazo(4,5-b)pyridin-2-yl)pyridin-2-amine

16. 2-pyridinamine, 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3h-imidazo(4,5-b)pyridin-2-yl)-

17. Miransertib (usan/inn)

18. Miransertib [usan:inn]

19. Miransertib (arq-092)

20. Unii-t1dqi1b52y

21. Gtpl9429

22. Schembl2187875

23. Arq 092 [who-dd]

24. Chembl4297188

25. Bcp19821

26. Ex-a1268

27. Nsc791328

28. Who 10490

29. Zinc72315647

30. Cs-5377

31. Db14982

32. Nsc-791328

33. Sb19688

34. Compound 21a [pmid: 27305487]

35. Ac-35486

36. Hy-19719

37. Db-105304

38. S6811

39. J3.532.768a

40. D11409

41. A922251

42. Q27456535

43. 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3himidazo(4,5-b)pyridin-2-yl)pyridin-2-amine

44. 6s1

2.4 Create Date

2011-08-01

3 Chemical and Physical Properties

Molecular Formula	C₂₇H₂₄N₆
Molecular Weight	432.5 g/mol
XLogP3	3.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	432.20624479 g/mol
Monoisotopic Mass	432.20624479 g/mol
Topological Polar Surface Area	95.6 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	653
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

Miransertib

Miransertib

ACCESS ALL DATA

Browse all information

CHEMISTRY

Discover Molecule Insights

DIGITAL CONTENT

2 News #PharmaBuzz

Filters