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    Moricizine

    FINISHED DOSAGE FORMULATIONS

    REF. STANDARDS & IMPURITIES

    PharmaCompass
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    2D Structure
    Also known as: 29560-58-5, Moracizine hydrochloride, Ethmozine, Ethmosine, Moricizine hcl, Moricizine (hydrochloride)
    Molecular Formula
    C22H26ClN3O4S
    Molecular Weight
    464.0  g/mol
    InChI Key
    GAQAKFHSULJNAK-UHFFFAOYSA-N
    FDA UNII
    71OK3Z1ESP
    An antiarrhythmia agent used primarily for ventricular rhythm disturbances.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate;hydrochloride
    2.1.2 InChI
    InChI=1S/C22H25N3O4S.ClH/c1-2-29-22(27)23-16-7-8-20-18(15-16)25(17-5-3-4-6-19(17)30-20)21(26)9-10-24-11-13-28-14-12-24;/h3-8,15H,2,9-14H2,1H3,(H,23,27);1H
    2.1.3 InChI Key
    GAQAKFHSULJNAK-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCOC(=O)NC1=CC2=C(C=C1)SC3=CC=CC=C3N2C(=O)CCN4CCOCC4.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    71OK3Z1ESP
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. En 313

    2. En-313

    3. En313

    4. Ethmozin

    5. Ethmozine

    6. Etmozin

    7. Hydrochloride, Moricizine

    8. Moracizin

    9. Moracizine

    10. Moricizine

    2.3.2 Depositor-Supplied Synonyms

    1. 29560-58-5

    2. Moracizine Hydrochloride

    3. Ethmozine

    4. Ethmosine

    5. Moricizine Hcl

    6. Moricizine (hydrochloride)

    7. Ethmozin

    8. Etmozin

    9. 71ok3z1esp

    10. Mls000830274

    11. Moricizine Hydrochloride [usp]

    12. En 313; Ethmosine; Ethmozin

    13. En 313

    14. Ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate;hydrochloride

    15. Moracizine Hcl

    16. Smr000036736

    17. Ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate, Hydrochloride

    18. Dsstox_cid_27766

    19. Dsstox_rid_82543

    20. Dsstox_gsid_47786

    21. Carbamic Acid, (10-(3-(4-morpholinyl)-l-oxopropyl)-10h-phenothiazin-2yl)-, Ethyl Ester, Hydrochloride

    22. Moricizine Hydrochloride (usp)

    23. Ethyl 10-(beta-n-morpholinylpropionyl)phenothiazine-2-carbamate Hydrochloride

    24. Chebi:60937

    25. Cas-29560-58-5

    26. Ncgc00016809-01

    27. Ncgc00016809-07

    28. Unii-71ok3z1esp

    29. Ethmozine (tn)

    30. Opera_id_267

    31. Ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate Hydrochloride

    32. Cambridge Id 5229972

    33. Ethyl Ether Of 10-(beta-morpholylpropionyl)phenthiazinecarbamino Acid Hydrochloride

    34. Moracizinehydrochloride

    35. Schembl41358

    36. (10-(3-(4-morpholinyl)-1-oxopropyl)-10h-phenothiazin-2-yl)carbamic Acid, Ethyl Ester, Monohydrochloride

    37. Mls000080120

    38. Regid_for_cid_34632

    39. Chembl1200334

    40. Dtxsid1047786

    41. Hy-b0615a

    42. Hms1571c04

    43. Ethyl 10-(3-morpholinopropanoyl)-

    44. Tox21_110622

    45. Moricizine Hydrochloride [mi]

    46. Akos030506898

    47. Tox21_110622_1

    48. Ccg-221051

    49. Moracizine Hydrochloride [mart.]

    50. Moricizine Hydrochloride [vandf]

    51. Phenothiazine-2-carbamic Acid, 10-(3-morpholinopropionyl)-, Ethyl Ester, Hydrochloride

    52. Moracizine Hydrochloride [who-dd]

    53. Moricizine Hydrochloride [usp-rs]

    54. Ncgc00180924-01

    55. Carbamic Acid, (10-(3-(4-morpholinyl)-1-oxopropyl)-10h-phenothiazin-2-yl)-, Ethyl Ester, Monohydrochloride

    56. Db-047605

    57. Cs-0013699

    58. E-313

    59. E-350

    60. Ft-0630550

    61. Moricizine Hydrochloride [orange Book]

    62. D02087

    63. Moricizine Hydrochloride [usp Impurity]

    64. Sr-01000614327

    65. Sr-01000614327-4

    66. Q27130132

    67. Ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate;hydron;chloride

    68. Carbamic Acid, N-(10-(3-(4-morpholinyl)-1-oxopropyl)-10h-phenothiazin-2-yl)-, Ethyl Ester, Hydrochloride (1:1)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 464.0 g/mol
    Molecular Formula C22H26ClN3O4S
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count6
    Exact Mass463.1332552 g/mol
    Monoisotopic Mass463.1332552 g/mol
    Topological Polar Surface Area96.4 Ų
    Heavy Atom Count31
    Formal Charge0
    Complexity601
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Arrhythmia Agents

    Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

    Voltage-Gated Sodium Channel Blockers

    A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS. (See all compounds classified as Voltage-Gated Sodium Channel Blockers.)