1. Dimethylacetamide
1. 127-19-5
2. Dimethylacetamide
3. Acetamide, N,n-dimethyl-
4. Dmac
5. Acetdimethylamide
6. Dimethyl Acetamide
7. N,n-dimethyl Acetamide
8. Dimethylamide Acetate
9. N,n-dimethylethanamide
10. Acetic Acid, Dimethylamide
11. Dimethylacetone Amide
12. Nsc 3138
13. N.n-dimethylacetamide
14. Hallucinogen
15. Cbc 510337
16. Sk 7176
17. Dimethylamid Kyseliny Octove
18. Mfcd00008686
19. Acetyl Dimethylamine
20. U-5954
21. N, N-dimethylacetamide
22. N,n-dimethyl-acetamide
23. Jcv5vdb3hy
24. Dtxsid5020499
25. Chebi:84254
26. Nsc-3138
27. Dsstox_cid_499
28. Acetyldimethylamine
29. Dsstox_rid_75625
30. Dsstox_gsid_20499
31. Cas-127-19-5
32. Hsdb 74
33. Ccris 4623
34. N,n-dimethylacetoamide
35. Unii-jcv5vdb3hy
36. Acetic Acid Dimethylamide
37. Dimethylamid Kyseliny Octove [czech]
38. Einecs 204-826-4
39. Dimethyacetamide
40. Dimethylactamide
41. N,n-dimethylacetamide Solution
42. Dimethylacteamide
43. Ai3-15276
44. Trimethylformamide
45. Dimeihyl Acetamide
46. Dimethyl-acetamide
47. N-dimethylacetamide
48. N,n-dimethyacetamide
49. N,n-dimethylactamide
50. N-acetyldimethylamine
51. N,n Dimethylacetamide
52. N,n,-dimethylacetamide
53. N,-n-dimethylacetamide
54. N,n -dimethylacetamide
55. N,n-di-methylacetamide
56. N,n-dimethylacet-amide
57. N, N-dimethylacetoamide
58. N,n-dimethyl Acetoamide
59. Dmac, Dimethylacetamide
60. N,n,-dimethyl-acetamide
61. Acetic Acid-dimethylamide
62. N,n-dimethyl- Acetamide
63. Ec 204-826-4
64. N,n-dimethylacetamide Solution (40% Or Less)
65. N,n-dimethyl-n-acetylamine
66. Ch3con(ch3)2
67. N, N-dimethylacetamide, Ep
68. Chembl11873
69. N,n-dimethylacetamide, >=99%
70. N,n-dimethylacetamide, Anhydrous
71. Dimethylacetamide [mart.]
72. Nsc3138
73. N,n-dimethylacetamide [ii]
74. N,n-dimethylacetamide [mi]
75. Wln: 1vn1 & 1
76. N,n-dimethylacetamide, Hplc Grade
77. Zinc1666602
78. Tox21_202174
79. Tox21_302787
80. N,n-dimethylacetamide [hsdb]
81. Nsc820333
82. Stl482892
83. N,n-dimethylacetamide [vandf]
84. Acetic Acid,amide,n,n-dimethyl
85. Akos000118789
86. N,n-dimethylacetamide-1,2-[13c2]
87. Cs-w023195
88. Hy-w042416
89. N,n-dimethylacetamide [usp-rs]
90. Nsc-820333
91. Dimethylacetamide [ep Monograph]
92. N,n-dimethylacetamide, P.a., 99.5%
93. N,n-dimethylacetamide, Ar, >=99.5%
94. Ncgc00159401-02
95. Ncgc00159401-03
96. Ncgc00256375-01
97. Ncgc00259723-01
98. Bp-31151
99. N,n-dimethylacetamide, Saj Special Grade
100. N,n-dimethylacetamide, Analytical Standard
101. N,n-dimethylacetamide, Anhydrous, 99.8%
102. Db-041302
103. D0641
104. Ft-0629514
105. Ft-0642826
106. N,n-dimethylacetamide, For Hplc, >=99.7%
107. N,n-dimethylacetamide, For Hplc, >=99.9%
108. N,n-dimethylacetamide, Reagentplus(r), 99%
109. C20339
110. N,n-dimethylacetamide, Reagentplus(r), >=99%
111. Q411452
112. Residual Solvent Class 2 - N,n-dimethylacetamide
113. N,n-dimethylacetamide, Saj First Grade, >=99.0%
114. N,n-dimethylacetamide, Uv Hplc Spectroscopic, 99%
115. W-108388
116. N,n-dimethylacetamide, Anhydrous, Zero2(tm), 99.8%
117. N,n-dimethylacetamide, Vetec(tm) Reagent Grade, 98%
118. Z32014266
119. Acetic Acid-dimethylamide 100 Microg/ml In Acetonitrile
120. F0001-0392
121. N,n-dimethylacetamide, Puriss. P.a., >=99.5% (gc)
122. N,n-dimethylacetamide, Spectrophotometric Grade, >=99%
123. Acetic Acid-dimethylamide 1000 Microg/ml In Acetonitrile
124. N,n-dimethylacetamide, For Peptide Synthesis, >=99.8% (gc)
125. 5y9
126. N,n-dimethylacetamide, Pharmagrade, Manufactured Under Appropriate Gmp Controls For Pharma And Biopharmaceutical Production., Ph Eur
| Molecular Weight | 87.12 g/mol |
|---|---|
| Molecular Formula | C4H9NO |
| XLogP3 | -0.8 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 87.068413911 g/mol |
| Monoisotopic Mass | 87.068413911 g/mol |
| Topological Polar Surface Area | 20.3 Ų |
| Heavy Atom Count | 6 |
| Formal Charge | 0 |
| Complexity | 58.6 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Commercial solvent tested as a parenteral drug vehicle and as an antitumor agent.
Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-200
Cryoprotective Agents
Substances that provide protection against the harmful effects of freezing temperatures. (See all compounds classified as Cryoprotective Agents.)
/N,N-DIMETHYLACETAMIDE/ ... READILY ABSORBED THROUGH SKIN ... .
Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963., p. 1834
N,N-dimethylacetamide is rapidly absorbed through biological membranes.
PMID:3530639 Kennedy GL Jr; Crit Rev Toxicol 17 (2): 129-82 (1986)
No correlation between personal airborne exposure and excretion of mono-methylacetamide in urine was detected during a full workshift (5 days). Most (n = 6) workers studied (n = 8) excreted about 13% of the calculated inhaled dose as metabolite in urine.
PMID:3681500 Borm PJ et al; J Occup Med 29 (11): 898-903 (1987)
DMAC is readily absorbed in man after oral, dermal, or inhalation exposure. ... About 2% of a dose of dimethylacetamide is recovered in the urine as MMAC /N-methylacetamide/ after inhalation; 10% is recovered after inhalation plus skin exposure. Exposure to 10 ppm of DMAC results in complete excretion of MMAC with in 30 hr. Maximal concns of 45 & 100 ppm (mg/L) of MMAC in the urine are found in subjects exposed both by inhalation & skin. In workers continuously exposed to DMAC vapor (inhalation plus skin) & subjected to DMAC airborne levels of 6-22 ppm ..., about 13.5% of the estimated dose is excreted as MMAC in the urine. Some workers may excrete about 30% of a dose as MMAC.
Ellenhorn, M.J., S. Schonwald, G. Ordog, J. Wasserberger. Ellenhorn's Medical Toxicology: Diagnosis and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams and Wilkins, 1997., p. 1673
For more Absorption, Distribution and Excretion (Complete) data for N,N-DIMETHYLACETAMIDE (7 total), please visit the HSDB record page.
N-DEMETHYLATION OF ... DIMETHYLACETAMIDE OCCURRED IN RAT, RESPECTIVE MONOMETHYLAMIDES APPEARING IN URINE ... IN THE CASE OF DIMETHYLACETAMIDE WAS DIDEMETHYLATED PRODUCT, ACETAMIDE, ALSO FOUND.
The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 429
ANALYSIS OF HUMAN URINE AFTER OCCUPATIONAL EXPOSURE TO DIMETHYLACETAMIDE SHOWS N-METHYLACETAMINE. /FROM TABLE/
Doull, J., C.D. Klaassen, and M. D. Amdur (eds.). Casarett and Doull's Toxicology. 2nd ed. New York: Macmillan Publishing Co., 1980., p. 707
Gas chromatographic analysis of the urine of rats which had received dimethylacetamide by the subcutaneous route indicated the presence of N-methyl-acetamide and acetamide. Both metabolites were also found ... in incubation mixtures of dimethylacetamide with rat liver homogenate. N-Methylacetamide was detected in the urine of human volunteers who had inhaled dimethylacetamide or absorbed dimethylacetamide vapor through the skin. Measurement of the amount of the metabolite N-methylacetamide excreted by individuals exposed to dimethylacetamide vapors with or without face masks which allowed the inhalation of air free of dimethylacetamide indicated that more dimethylacetamide was absorbed through the lung than through the skin. ... Only 2-10% of the amount of dimethylacetamide inhaled was recovered in the urine in the form of N-methylacetamide. It has been suggested that the major urinary metabolite of the analogous dimethylformamide is N-(hydroxymethyl)-N-methylformamide and not N-methylformamide, since the carbinolamide decomposes on the gas chromatography column (to N-methylformamide) but is relatively stable in aqueous solution. In analogy, it would be logical to assume that the N-methylacetamide found in the urine after exposure to dimethylacetamide really arose from chemical breakdown of N-(hydroxymethyl)-N-methylacetamide during the analytical process.
Snyder, R. (ed.). Ethel Browning's Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II: Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier, 1990., p. 144
N,N-dimethylacetamide is metabolized by demethylation first to monomethyl derivatives and then to the parent acetamide.
PMID:3530639 Kennedy GL Jr; Crit Rev Toxicol 17 (2): 129-82 (1986)
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