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    Nafronyl Oxalate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    GLOBAL SALES INFORMATION

    MARKET PLACE

    ANALYTICAL

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    2D Structure
    Also known as: 3200-06-4, Naftidrofuryl oxalate, Nafronyl oxalate salt, Naftidrofuryl (oxalate), Dusodril, Praxilene
    Molecular Formula
    C26H35NO7
    Molecular Weight
    473.6  g/mol
    InChI Key
    SSAJNPNVUYMUCI-UHFFFAOYSA-N
    FDA UNII
    5ADB8D9388
    A drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1310) It may also be an antagonist at 5HT-2 serotonin receptors.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-(diethylamino)ethyl 2-(naphthalen-1-ylmethyl)-3-(oxolan-2-yl)propanoate;oxalic acid
    2.1.2 InChI
    InChI=1S/C24H33NO3.C2H2O4/c1-3-25(4-2)14-16-28-24(26)21(18-22-12-8-15-27-22)17-20-11-7-10-19-9-5-6-13-23(19)20;3-1(4)2(5)6/h5-7,9-11,13,21-22H,3-4,8,12,14-18H2,1-2H3;(H,3,4)(H,5,6)
    2.1.3 InChI Key
    SSAJNPNVUYMUCI-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCN(CC)CCOC(=O)C(CC1CCCO1)CC2=CC=CC3=CC=CC=C32.C(=O)(C(=O)O)O
    2.2 Other Identifiers
    2.2.1 UNII
    5ADB8D9388
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Artocoron

    2. Azunaftil

    3. Di Actane

    4. Di-actane

    5. Dusodril

    6. Gvatran

    7. Ls 121

    8. Ls-121

    9. Ls121

    10. Nafronyl

    11. Nafronyloxalate

    12. Nafti Puren

    13. Nafti Ratiopharm

    14. Nafti Von Ct

    15. Nafti-puren

    16. Nafti-ratiopharm

    17. Naftidrofuryl

    18. Naftifurin Oxalate

    19. Naftilong

    20. Naftilux

    21. Naftiratiopharm

    22. Oxalate, Nafronyl

    23. Oxalate, Naftifurin

    24. Praxilne

    25. Praxilene

    2.3.2 Depositor-Supplied Synonyms

    1. 3200-06-4

    2. Naftidrofuryl Oxalate

    3. Nafronyl Oxalate Salt

    4. Naftidrofuryl (oxalate)

    5. Dusodril

    6. Praxilene

    7. Naftidrofuryl Hydrogen Oxalate

    8. Citoxid

    9. 2-(diethylamino)ethyl 3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoate Oxalate

    10. Di-actane

    11. Nafronyl Acid Oxalate

    12. Ls-121

    13. Nsc-225233

    14. Eu-1806

    15. Iridus

    16. Nafronyl Oxalate (usan)

    17. Nafronyl Oxalate [usan]

    18. Dsstox_cid_25533

    19. Dsstox_rid_80935

    20. Dsstox_gsid_45533

    21. Clarantin

    22. 2-(diethylamino)ethyl 2-(naphthalen-1-ylmethyl)-3-(oxolan-2-yl)propanoate;oxalic Acid

    23. 2-(diethylamino)ethyl Tetrahydro-.alpha.-(1-naphthylmethyl)-2-furanpropionate Oxalate (1:1)

    24. Chembl1439099

    25. Nafronyl Oxalate Salt, Analytical Standard

    26. Smr000539007

    27. 5adb8d9388

    28. Cas-3200-06-4

    29. Ls 121

    30. Nsc225233

    31. Sr-01000789261

    32. Naftidrofuryloxalate

    33. Praxilene (tn)

    34. Prestwick_696

    35. 2-furanpropanoic Acid, Tetrahydro-.alpha.-(1-naphthalenylmethyl)-, 2-(diethylamino)ethyl Ester, Ethanedioate (1:1)

    36. Ncgc00016982-01

    37. Mls000766889

    38. Mls001032044

    39. Mls001173344

    40. Mls002222244

    41. Schembl123848

    42. Spectrum1503419

    43. Dtxsid6045533

    44. Hms501a20

    45. Hms1569k15

    46. Hms1922c14

    47. Hms2093e15

    48. Hms2096k15

    49. Hms2875a08

    50. Hms3713k15

    51. Hms3886i06

    52. Pharmakon1600-01503419

    53. Nafronyl Acid Oxalate [mi]

    54. Naftidrofuryl Oxalate [jan]

    55. Bcp19865

    56. Hy-b1107

    57. Tox21_110724

    58. Ccg-40305

    59. Nsc758462

    60. S5472

    61. Naftidrofuryl Oxalate [mart.]

    62. Akos015960731

    63. Naftidrofuryl Oxalate [who-dd]

    64. Tox21_110724_1

    65. Cs-4704

    66. Nsc-758462

    67. 2-(diethylamino)ethyl 2-(naphthalen-1-ylmethyl)-3-(oxolan-2-yl)propanoate,oxalic Acid

    68. Ncgc00095050-01

    69. Ncgc00095050-02

    70. Ncgc00178213-05

    71. Ac-12093

    72. Ft-0629863

    73. D05107

    74. A937354

    75. J-018595

    76. Naftidrofuryl Hydrogen Oxalate [ep Monograph]

    77. Sr-01000789261-2

    78. Sr-01000789261-3

    79. Q27261749

    80. 2-furanpropionic Acid, 2-(diethylamino)ethyl Ester Oxalate (1:1)

    81. 2-furanpropionic Acid, 2-(diethylamino)ethyl Esteroxalate (1:1)

    82. Naftidrofuryl Oxalate, British Pharmacopoeia (bp) Reference Standard

    83. 2-furanpropanoic Acid, 2-(diethylamino)ethyl Ester, Ethanedioate (1:1)

    84. Alpha-(1-naphthylmethyl)-2-tetrahydrofuranpropionic Acid Diethylaminoethyl Ester

    85. 2-furanpropanoic Acid, Tetrahydro-a-(1-naphthalenylmethyl)-, 2-(diethylamino)ethyl Ester, Ethanedioate (1:1)

    86. 2-furanpropanoic Acid, Tetrahydro-a-(1-naphthalenylmethyl)-,2-(diethylamino)ethyl Ester, Ethanedioate (1:1)

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 473.6 g/mol
    Molecular Formula C26H35NO7
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count12
    Exact Mass473.24135246 g/mol
    Monoisotopic Mass473.24135246 g/mol
    Topological Polar Surface Area113 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity536
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Vasodilator Agents

    Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

    Serotonin Antagonists

    Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)