Please Wait
Applying Filters...
menu
    • menu
    DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

    Virtual Booth

    Contact Supplier

    Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    With Fermion, start the journey of your innovative API.

    Virtual Booth

    Contact Supplier

    Bloomage is a one-stop source for CEP Sodium Hyaluronate and Hyaluronic Acid// FDA-inspected & GMP-certified.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    Menu

    Naloxegol Oxalate

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

    FINISHED DOSAGE FORMULATIONS

    DRUG PRODUCT COMPOSITIONS

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    DIGITAL CONTENT

    GLOBAL SALES INFORMATION

    MARKET PLACE

    PATENTS & EXCLUSIVITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 48,251Xls

    Filters

    clear-filterReset all filters
    2D Structure
    Also known as: 1354744-91-4, Nktr-118 oxalate, Naloxegol (oxalate), Naloxegol oxalate [usan], Az13337019 oxalate, Az-13337019 oxalate
    Molecular Formula
    C36H55NO15
    Molecular Weight
    741.8  g/mol
    InChI Key
    MNYIRXLCPODKLG-VUTNLTPYSA-N
    FDA UNII
    65I14TNM33
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (4R,4aS,7S,7aR,12bS)-7-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol;oxalic acid
    2.1.2 InChI
    InChI=1S/C34H53NO11.C2H2O4/c1-3-9-35-10-8-33-30-26-4-5-27(36)31(30)46-32(33)28(6-7-34(33,37)29(35)25-26)45-24-23-44-22-21-43-20-19-42-18-17-41-16-15-40-14-13-39-12-11-38-2;3-1(4)2(5)6/h3-5,28-29,32,36-37H,1,6-25H2,2H3;(H,3,4)(H,5,6)/t28-,29+,32-,33-,34+;/m0./s1
    2.1.3 InChI Key
    MNYIRXLCPODKLG-VUTNLTPYSA-N
    2.1.4 Canonical SMILES
    COCCOCCOCCOCCOCCOCCOCCOC1CCC2(C3CC4=C5C2(C1OC5=C(C=C4)O)CCN3CC=C)O.C(=O)(C(=O)O)O
    2.1.5 Isomeric SMILES
    COCCOCCOCCOCCOCCOCCOCCO[C@H]1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC=C)O.C(=O)(C(=O)O)O
    2.2 Other Identifiers
    2.2.1 UNII
    65I14TNM33
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. 1354744-91-4

    2. Nktr-118 Oxalate

    3. Naloxegol (oxalate)

    4. Naloxegol Oxalate [usan]

    5. Az13337019 Oxalate

    6. Az-13337019 Oxalate

    7. 65i14tnm33

    8. Moventig

    9. (4r,4as,7s,7ar,12bs)-7-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol;oxalic Acid

    10. Naloxegol Oxalate (usan)

    11. Unii-65i14tnm33

    12. Movantik (tn)

    13. Moventig (tn)

    14. Nktr-118-oxalate

    15. Naloxegol Oxalate [mi]

    16. Naloxegol Oxalate(nktr-118)

    17. Chembl2219416

    18. Schembl20839999

    19. Hy-a0118a

    20. Dtxsid50159395

    21. Naloxegol Oxalate [who-dd]

    22. Akos030526444

    23. Cs-5349

    24. Naloxegol Oxalate [orange Book]

    25. Nktr-118;az-13337019 Oxalate

    26. Ac-36031

    27. Movantik Component Naloxegol Oxalate

    28. Az 13337019

    29. Naloxegol Oxalate Component Of Movantik

    30. D10375

    31. Q27263878

    32. 4,5.alpha.-epoxy-6.alpha.-((3,6,7,12,15,18,21-heptaoxadocosyl)oxy)-17-(prop-2-enyl)morphinan-3,14-diol Hydrogen Ethanedioate

    33. 4,5alpha-epoxy-6alpha-((3,6,7,12,15,18,21-heptaoxadocosyl)oxy)-17-(prop-2-enyl)morphinan-3,14-diol Hydrogen Ethanedioate

    34. Morphinan-3,14-diol, 4,5-epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propen-1-yl)-, (5.alpha.,6.alpha.)-, Ethanedioate (1:1)

    35. Morphinan-3,14-diol, 4,5-epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propen-1-yl)-, (5alpha,6alpha)-, Ethanedioate (1:1)

    2.4 Create Date
    2012-05-14
    3 Chemical and Physical Properties
    Molecular Weight 741.8 g/mol
    Molecular Formula C36H55NO15
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count16
    Rotatable Bond Count25
    Exact Mass741.35717005 g/mol
    Monoisotopic Mass741.35717005 g/mol
    Topological Polar Surface Area201 Ų
    Heavy Atom Count52
    Formal Charge0
    Complexity971
    Isotope Atom Count0
    Defined Atom Stereocenter Count5
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Indication

    Treatment of opioid-induced constipation (OIC) in adult patients who have had an inadequate response to laxative(s).

    5 Pharmacology and Biochemistry
    5.1 FDA Pharmacological Classification
    5.1.1 Pharmacological Classes
    Opioid Antagonists [MoA]; Opioid Antagonist [EPC]
    5.2 ATC Code

    A06AH03