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    Namenda

    ACTIVE PHARMA INGREDIENTS

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    2D Structure
    Also known as: 41100-52-1, Memantine hcl, Namenda, 3,5-dimethyl-1-adamantanamine hydrochloride, 3,5-dimethyladamantan-1-amine hydrochloride, Akatinol
    Molecular Formula
    C12H22ClN
    Molecular Weight
    215.76  g/mol
    InChI Key
    LDDHMLJTFXJGPI-UHFFFAOYSA-N
    FDA UNII
    JY0WD0UA60
    AMANTADINE derivative that has some dopaminergic effects. It has been proposed as an antiparkinson agent.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3,5-dimethyladamantan-1-amine;hydrochloride
    2.1.2 InChI
    InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
    2.1.3 InChI Key
    LDDHMLJTFXJGPI-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    JY0WD0UA60
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1,3-dimethyl-5-aminoadamantane

    2. 1-amino-3,5-dimethyladamantane

    3. Axura

    4. D 145

    5. D-145

    6. D145

    7. Ebixa

    8. Memantin

    9. Memantine

    10. Namenda

    2.3.2 Depositor-Supplied Synonyms

    1. 41100-52-1

    2. Memantine Hcl

    3. Namenda

    4. 3,5-dimethyl-1-adamantanamine Hydrochloride

    5. 3,5-dimethyladamantan-1-amine Hydrochloride

    6. Akatinol

    7. Axura

    8. Namenda Xr

    9. Memary

    10. Ebixa

    11. Memantine Mylan

    12. 1-amino-3,5-dimethyladamantane Hydrochloride

    13. Memantine Merz

    14. Memantine.hcl

    15. Memantine Accord

    16. Memantine Lek

    17. Memantine (hydrochloride)

    18. Acrescent

    19. Balaxur

    20. Auxura

    21. Unii-jy0wd0ua60

    22. 3,5-dimethyladamantan-1-amine;hydrochloride

    23. Jy0wd0ua60

    24. Mfcd00214336

    25. Memantine Ratiopharm

    26. Memantine Hydrochloride [usan]

    27. Chebi:64323

    28. Sun-y7017

    29. Nsc-102290

    30. 3,5-dimethyladamantan-1-aminium Chloride

    31. D-145

    32. Mls001332605

    33. 3,5-dimethyl-1-aminoadamantane Hydrochloride

    34. (3,5-dimethyl-1-adamantyl)amine Hydrochloride

    35. 3,5-dimethyltricyclo(3.3.1.1(3,7))decan-1-amine Hydrochloride

    36. Fp-01

    37. 1,3-dimethyl-5-adamantanamine Hcl

    38. 3,5-dimethyltricyclo[3.3.1.13,7]decan-1-amine Hydrochloride

    39. 41100-52-1 (hcl)

    40. Tricyclo[3.3.1.13,7]decan-1-amine, 3,5-dimethyl-, Hydrochloride

    41. D 145

    42. Mantine

    43. Ebixza

    44. 3,5-dimethyl-tricyclo[3.3.1.13,7]decan-1-amine Hydrochloride

    45. 3,5-dimethyltricyclo(3.3.1.13,7)decan-1-amine Hydrochloride

    46. 3,5-dimethyltricyclo(3.3.1.1(sup 3,7))decan-1-amine Hydrochloride

    47. Tricyclo(3.3.1.1(sup 3,7))decan-1-amine, 3,5-dimethyl-, Hydrochloride

    48. 3,5-dimethyl-1-adamantylamine

    49. 3,5-dimethyl-1-aminoadamantane

    50. Smr000875213

    51. Sr-01000075458

    52. Sun Y7017

    53. Einecs 255-219-6

    54. Namenda (tn)

    55. Memary (tn)

    56. Marixino

    57. Nsc 102290

    58. D-145 (hydrochloride)

    59. Schembl3053

    60. C12h21n.hcl

    61. Chembl1699

    62. Mls001332606

    63. Spectrum1501121

    64. Hy-b0365a

    65. Dtxsid90961439

    66. Memantine Hydrochloride (namenda)

    67. N06dx01

    68. Nmi-131

    69. Hms1571c17

    70. Hms1921h03

    71. Pharmakon1600-01501121

    72. Memantine Hydrochloride (jan/usp)

    73. Memantine Hydrochloride [mi]

    74. Tox21_500861

    75. Ac-559

    76. Ccg-39018

    77. Memantine Hydrochloride [jan]

    78. Mrz-2/145

    79. Nsc102290

    80. Nsc757843

    81. S2043

    82. Akos015889460

    83. Bcp9000253

    84. Lp00861

    85. Memantine Hydrochloride [mart.]

    86. Nc00680

    87. Memantine Hydrochloride [usp-rs]

    88. Memantine Hydrochloride [who-dd]

    89. Ncgc00094186-01

    90. Ncgc00094186-02

    91. Ncgc00094186-03

    92. Ncgc00261546-01

    93. As-13331

    94. Bm164662

    95. Memantine Hydrochloride [ema Epar]

    96. Sy057917

    97. 3,5-dimethyladamantan-1-aminehydrochloride

    98. Am20070534

    99. D3608

    100. Eu-0100861

    101. Ft-0650723

    102. M-145

    103. Memantine Hydrochloride [orange Book]

    104. Sw060653-4

    105. 1-amino-3,5-dimethyl-adamantane Hydrochloride

    106. 3,5-dimethyladamantan-1-amine Hy-drochloride

    107. 3,5-dimethyladamantan-1-amine;hydrochloride.

    108. D04905

    109. M 9292

    110. Memantine Hydrochloride [usp Monograph]

    111. Namzaric Component Memantine Hydrochloride

    112. Memantine Hydrochloride Component Of Namzaric

    113. Sr-01000075458-1

    114. Sr-01000075458-3

    115. Sr-01000075458-8

    116. Q27133218

    117. Z1551429722

    118. Tricyclo(3.3.1.1(3,7))decan-1-amine, 3,5-dimethyl-, Hydrochloride

    119. Tricyclo[3.3.1.13,7]decan-1-amine, 3,5-dimethyl-, Hydrochloride (1:1) (ca Index Name)

    120. 1-amino-3,5-dimethyladamantane . Hcl 3,5-dimethyl-1-aminoadamantane . Hcl Memantine . Hydrochloride

    2.4 Create Date
    2005-07-19
    3 Chemical and Physical Properties
    Molecular Weight 215.76 g/mol
    Molecular Formula C12H22ClN
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count1
    Rotatable Bond Count0
    Exact Mass215.1440774 g/mol
    Monoisotopic Mass215.1440774 g/mol
    Topological Polar Surface Area26 Ų
    Heavy Atom Count14
    Formal Charge0
    Complexity240
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameMemantine hydrochloride
    PubMed HealthMemantine (By mouth)
    Drug ClassesCentral Nervous System Agent
    Drug LabelNamenda (memantine hydrochloride) is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C12H21N...
    Active IngredientMemantine hydrochloride
    Dosage FormTablet
    Routeoral; Oral
    Strength5mg; 10mg
    Market StatusTentative Approval
    CompanyAmneal Pharms; Alembic; Upsher Smith; Mylan Pharma; Unichem Pharms (usa); Apotex; Lupin Pharms; Aurobindo Pharma; Torrent Pharms; Macleods Pharms; Jubilant Life

    2 of 6  
    Drug NameNamenda
    PubMed HealthMemantine (By mouth)
    Drug ClassesCentral Nervous System Agent
    Drug LabelNamenda (memantine hydrochloride) is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C12H21N...
    Active IngredientMemantine hydrochloride
    Dosage FormTablet; Solution
    RouteOral
    Strength2mg/ml; 5mg; 10mg
    Market StatusPrescription
    CompanyForest Labs

    3 of 6  
    Drug NameNamenda xr
    Drug LabelNAMENDA XR is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C12H21NHCl and the molecular wei...
    Active IngredientMemantine hydrochloride
    Dosage FormCapsule, extended release
    RouteOral
    Strength7mg; 14mg; 21mg; 28mg
    Market StatusPrescription
    CompanyForest Labs

    4 of 6  
    Drug NameMemantine hydrochloride
    PubMed HealthMemantine (By mouth)
    Drug ClassesCentral Nervous System Agent
    Drug LabelNamenda (memantine hydrochloride) is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C12H21N...
    Active IngredientMemantine hydrochloride
    Dosage FormTablet
    Routeoral; Oral
    Strength5mg; 10mg
    Market StatusTentative Approval
    CompanyAmneal Pharms; Alembic; Upsher Smith; Mylan Pharma; Unichem Pharms (usa); Apotex; Lupin Pharms; Aurobindo Pharma; Torrent Pharms; Macleods Pharms; Jubilant Life

    5 of 6  
    Drug NameNamenda
    PubMed HealthMemantine (By mouth)
    Drug ClassesCentral Nervous System Agent
    Drug LabelNamenda (memantine hydrochloride) is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C12H21N...
    Active IngredientMemantine hydrochloride
    Dosage FormTablet; Solution
    RouteOral
    Strength2mg/ml; 5mg; 10mg
    Market StatusPrescription
    CompanyForest Labs

    6 of 6  
    Drug NameNamenda xr
    Drug LabelNAMENDA XR is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C12H21NHCl and the molecular wei...
    Active IngredientMemantine hydrochloride
    Dosage FormCapsule, extended release
    RouteOral
    Strength7mg; 14mg; 21mg; 28mg
    Market StatusPrescription
    CompanyForest Labs

    4.2 Drug Indication

    Treatment of patients with moderate to severe Alzheimer's disease.

    Treatment of patients with moderate to severe Alzheimers disease.

    Treatment of patients with moderate to severe Alzheimers disease.

    Treatment of patients with moderate to severe Alzheimers disease.

    Treatment of patients with moderate to severe Alzheimer's disease.

    Treatment of patients with moderate to severe Alzheimers disease

    Treatment of patients with moderate to severe Alzheimers disease.

    Treatment of patients with moderate to severe Alzheimers disease.

    Treatment of Alzheimers disease

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antiparkinson Agents

    Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)

    Dopamine Agents

    Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons. (See all compounds classified as Dopamine Agents.)

    Excitatory Amino Acid Antagonists

    Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists. (See all compounds classified as Excitatory Amino Acid Antagonists.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    NMDA Receptor Antagonists [MoA]; N-methyl-D-aspartate Receptor Antagonist [EPC]
    5.3 ATC Code

    N06DX01

    N06DX01

    N06DX01

    N06DX01

    N06DX01

    N06DX01

    N06DX01

    N06DX01

    N06D

    N06DA52