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    Technical details about Navtemadlin, learn more about the structure, uses, toxicity, action, side effects and more

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    Navtemadlin

    DEVELOPMENTS

    DIGITAL CONTENT

    PharmaCompass

    Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

    Athena Pharmaceutiques is a Partner of Choice for Drug Delivery & Life Cycle Management.

    2D Structure
    1. Also known as: Amg-232, 1352066-68-2, Amg 232, Amg232, Navtemadlin, Krt-232
    Molecular Formula
    C28H35Cl2NO5S
    Molecular Weight
    568.6  g/mol
    InChI Key
    DRLCSJFKKILATL-YWCVFVGNSA-N
    FDA UNII
    7R7G6EH5UL
    Navtemadlin is an orally available inhibitor of MDM2 (murine double minute 2), with potential antineoplastic activity. Upon oral administration,navtemadlin binds to the MDM2 protein and prevents its binding to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the transcriptional activity of p53 is restored. This leads to p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein and a negative regulator of the p53 pathway, is overexpressed in cancer cells; it plays a key role in cancer cell proliferation and survival.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(2S)-3-methyl-1-propan-2-ylsulfonylbutan-2-yl]-2-oxopiperidin-3-yl]acetic acid
    2.1.2 InChI
    InChI=1S/C28H35Cl2NO5S/c1-17(2)24(16-37(35,36)18(3)4)31-26(19-9-11-21(29)12-10-19)23(20-7-6-8-22(30)13-20)14-28(5,27(31)34)15-25(32)33/h6-13,17-18,23-24,26H,14-16H2,1-5H3,(H,32,33)/t23-,24-,26-,28-/m1/s1
    2.1.3 InChI Key
    DRLCSJFKKILATL-YWCVFVGNSA-N
    2.1.4 Canonical SMILES
    CC(C)C(CS(=O)(=O)C(C)C)N1C(C(CC(C1=O)(C)CC(=O)O)C2=CC(=CC=C2)Cl)C3=CC=C(C=C3)Cl
    2.1.5 Isomeric SMILES
    CC(C)[C@@H](CS(=O)(=O)C(C)C)N1[C@@H]([C@H](C[C@](C1=O)(C)CC(=O)O)C2=CC(=CC=C2)Cl)C3=CC=C(C=C3)Cl
    2.2 Other Identifiers
    2.2.1 UNII
    7R7G6EH5UL
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-(5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic Acid

    2. Amg 232

    2.3.2 Depositor-Supplied Synonyms

    1. Amg-232

    2. 1352066-68-2

    3. Amg 232

    4. Amg232

    5. Navtemadlin

    6. Krt-232

    7. Mdm2 Inhibitor Amg-232

    8. Navtemadlin [usan]

    9. 7r7g6eh5ul

    10. Chembl3125702

    11. 2-[(3r,5r,6s)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(2s)-3-methyl-1-propan-2-ylsulfonylbutan-2-yl]-2-oxopiperidin-3-yl]acetic Acid

    12. Navtemadlin [inn]

    13. Unii-7r7g6eh5ul

    14. Krt232

    15. Schembl9993310

    16. Amg 232 [who-dd]

    17. Gtpl11133

    18. Dtxsid101025652

    19. Bdbm50448947

    20. Nsc781515

    21. Nsc789723

    22. Who 11546

    23. Zinc103248035

    24. Compound 2 [pmid: 24456472]

    25. Cs-3282

    26. Db15299

    27. Nsc-781515

    28. Nsc-789723

    29. Ncgc00387801-04

    30. Ncgc00387801-05

    31. Ac-29027

    32. As-17007

    33. Hy-12296

    34. A910091

    35. (3r,5r,6s)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((1s)-2-methyl-1-(((1-methylethyl)sulfonyl)methyl)propyl)-2-oxo-3-piperidineacetic Acid

    36. {(3r,5r,6s)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3- Methyl-1-[(2s)-3-methyl-1-(propane-2-sulfonyl)butan2-yl]-2-oxopiperidin-3-yl}acetic Acid

    37. 1447813-21-9

    38. 3-iperidineacetic Acid, 5-(3-hlorophenyl)-6-(4-hlorophenyl)-3-ethyl-1-(1s)-2-ethyl-1-[(1-ethylethyl)ulfonyl]ethyl]ropyl]-2-xo-, (3r,5r,6s)-

    39. 3-piperidineacetic Acid, 5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(1s)-2-methyl-1-[[(1-methylethyl)sulfonyl]methyl]propyl]-2-oxo-, (3r,5r,6s)-

    2.4 Create Date
    2012-08-19
    3 Chemical and Physical Properties
    Molecular Weight 568.6 g/mol
    Molecular Formula C28H35Cl2NO5S
    XLogP35.8
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count9
    Exact Mass567.1612998 g/mol
    Monoisotopic Mass567.1612998 g/mol
    Topological Polar Surface Area100 Ų
    Heavy Atom Count37
    Formal Charge0
    Complexity912
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
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