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2D Structure
Also known as: Nedaplatin, 95734-82-0, Nsc 375101d, Azane;2-hydroxyacetic acid;platinum, C2h8n2o3pt, C2-h8-n2-o3-pt
Molecular Formula
C2H10N2O3Pt
Molecular Weight
305.20  g/mol
InChI Key
ZAXCMPAWRCMABN-UHFFFAOYSA-N

Nedaplatin is a second-generation cisplatin analogue with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. This agent appears to be less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin.
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
azane;2-hydroxyacetic acid;platinum
2.1.2 InChI
InChI=1S/C2H4O3.2H3N.Pt/c3-1-2(4)5;;;/h3H,1H2,(H,4,5);2*1H3;
2.1.3 InChI Key
ZAXCMPAWRCMABN-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C(C(=O)O)O.N.N.[Pt]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. (glycolato-o,o')diammineplatinum Ii

2. 254-s

3. Cgdp-ii

4. Cis-diammine(glycolato)platinum Ii

5. Nedaplatin

6. Nsc 375101d

7. Nsc-375101d

2.2.2 Depositor-Supplied Synonyms

1. Nedaplatin

2. 95734-82-0

3. Nsc 375101d

4. Azane;2-hydroxyacetic Acid;platinum

5. C2h8n2o3pt

6. C2-h8-n2-o3-pt

7. Nsc-375101d

8. Cis-diammine(glycolato)platinum(ii)

9. (glycolato-o,o')diammineplatinum(ii)

10. Hms2089p16

11. Akos025311233

2.3 Create Date
2006-07-28
3 Chemical and Physical Properties
Molecular Weight 305.20 g/mol
Molecular Formula C2H10N2O3Pt
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count0
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area59.5
Heavy Atom Count8
Formal Charge0
Complexity44.1
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count4
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)