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    Nedocromil Sodium

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: 69049-74-7, Tilade, Alocril, Fpl 59002kp, Nedocromil sodium [usan], Rapitil
    Molecular Formula
    C19H15NNa2O7
    Molecular Weight
    415.3  g/mol
    InChI Key
    JQEKDNLKIVGXAU-UHFFFAOYSA-L
    FDA UNII
    ET8IF4KS1T
    A pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with ASTHMA, including EOSINOPHILS; NEUTROPHILS; MACROPHAGES; MAST CELLS; MONOCYTES; AND PLATELETS.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    disodium;9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylate
    2.1.2 InChI
    InChI=1S/C19H17NO7.2Na/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11;;/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26);;/q;2*+1/p-2
    2.1.3 InChI Key
    JQEKDNLKIVGXAU-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    CCCC1=C2C(=CC3=C1OC(=CC3=O)C(=O)[O-])C(=O)C=C(N2CC)C(=O)[O-].[Na+].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    ET8IF4KS1T
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4h-pyrano(3,2-g)quinoline-2,8-dicarboxylic Acid

    2. Alocril

    3. Brionil

    4. Calcium, Nedocromil

    5. Cetimil

    6. Fpl 59002

    7. Fpl-59002

    8. Fpl59002

    9. Halamid

    10. Irtan

    11. Nedocromil

    12. Nedocromil Calcium

    13. Nedocromil, Calcium Salt (1:1)

    14. Nedocromil, Disodium Salt

    15. Nedocromil, Disodium Salt, Hydrate

    16. Rapitil

    17. Sodium, Nedocromil

    18. Tilad

    19. Tilade

    20. Tilaire

    21. Tilavist

    2.3.2 Depositor-Supplied Synonyms

    1. 69049-74-7

    2. Tilade

    3. Alocril

    4. Fpl 59002kp

    5. Nedocromil Sodium [usan]

    6. Rapitil

    7. Tilarin

    8. Tayled

    9. Fpl-59002kp

    10. Nedocromil Disodium Salt

    11. Et8if4ks1t

    12. Chebi:7493

    13. Sodium 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4h-pyrano[3,2-g]quinoline-2,8-dicarboxylate

    14. Nedocromil Sodium (usan)

    15. Disodium;9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylate

    16. 4h-pyrano(3,2-g)quinoline-2,8-dicarboxylic Acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, Disodium Salt

    17. Unii-et8if4ks1t

    18. Abrevia

    19. Tilavist

    20. Alocril (tn)

    21. Tilade (tn)

    22. Chembl915

    23. Disodium-9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4h-pyrano(3,2-g)quinoline-2,8-dicarboxylate

    24. Schembl24944

    25. Nedocromil Sodium [jan]

    26. Dtxsid00219115

    27. Nedocromil Sodium [vandf]

    28. Nedocromil Sodium [mart.]

    29. Nedocromil Sodium [who-dd]

    30. Nedocromil Disodium Salt [mi]

    31. Akos015909770

    32. Nedocromil Sodium [orange Book]

    33. As-83242

    34. Hy-16344

    35. Cs-0006296

    36. Ft-0603491

    37. D00527

    38. A915577

    39. Q27107508

    40. 4h-pyrano(3,2-g)quinoline-2,8-dicarboxylic Acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, Sodium Salt (1:2)

    41. Disodium 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4h-pyrano[3,2-g]quinoline-2,8-dicarboxylate

    42. Disodium 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4h-pyrano-[3,2-g]-quinoline-2,8-dicarboxylate

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 415.3 g/mol
    Molecular Formula C19H15NNa2O7
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count3
    Exact Mass415.06439038 g/mol
    Monoisotopic Mass415.06439038 g/mol
    Topological Polar Surface Area127 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity742
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameAlocril
    PubMed HealthNedocromil
    Drug ClassesAntiasthma, Mast Cell Stabilizer, Ophthalmologic Agent
    Drug LabelALOCRIL (nedocromil sodium ophthalmic solution) 2% is a clear, yellow, sterile solution for topical ophthalmic use.Nedocromil sodium is represented by the following structural formula:...
    Active IngredientNedocromil sodium
    Dosage FormSolution/drops
    RouteOphthalmic
    Strength2%
    Market StatusPrescription
    CompanyAllergan

    2 of 4  
    Drug NameNedocromil sodium
    Drug LabelALOCRIL (nedocromil sodium ophthalmic solution) 2% is a clear, yellow, sterile solution for topical ophthalmic use.Nedocromil sodium is represented by the following structural formula:...
    Active IngredientNedocromil sodium
    Dosage FormSolution/drops
    RouteOphthalmic
    Strength2%
    Market StatusPrescription
    CompanyAkorn

    3 of 4  
    Drug NameAlocril
    PubMed HealthNedocromil
    Drug ClassesAntiasthma, Mast Cell Stabilizer, Ophthalmologic Agent
    Drug LabelALOCRIL (nedocromil sodium ophthalmic solution) 2% is a clear, yellow, sterile solution for topical ophthalmic use.Nedocromil sodium is represented by the following structural formula:...
    Active IngredientNedocromil sodium
    Dosage FormSolution/drops
    RouteOphthalmic
    Strength2%
    Market StatusPrescription
    CompanyAllergan

    4 of 4  
    Drug NameNedocromil sodium
    Drug LabelALOCRIL (nedocromil sodium ophthalmic solution) 2% is a clear, yellow, sterile solution for topical ophthalmic use.Nedocromil sodium is represented by the following structural formula:...
    Active IngredientNedocromil sodium
    Dosage FormSolution/drops
    RouteOphthalmic
    Strength2%
    Market StatusPrescription
    CompanyAkorn

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Asthmatic Agents

    Drugs that are used to treat asthma. (See all compounds classified as Anti-Asthmatic Agents.)

    Anti-Allergic Agents

    Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

    Anti-Inflammatory Agents

    Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

    Mast Cell Stabilizers

    Compounds that prevent the release of inflammatory mediators from MAST CELLS. (See all compounds classified as Mast Cell Stabilizers.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Mast Cell Stabilizer [EPC]; Decreased Histamine Release [PE]