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    Nefiracetam

    ACTIVE PHARMA INGREDIENTS

    PharmaCompass
    Xls

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    2D Structure
    Also known as: 77191-36-7, N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide, Translon, Dm 9384, Nefiracetam [inn], Motiva
    Molecular Formula
    C14H18N2O2
    Molecular Weight
    246.30  g/mol
    InChI Key
    NGHTXZCKLWZPGK-UHFFFAOYSA-N
    FDA UNII
    1JK12GX30N
    Nefiracetam has been used in trials studying the treatment of Alzheimer's Disease.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide
    2.1.2 InChI
    InChI=1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17)
    2.1.3 InChI Key
    NGHTXZCKLWZPGK-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(C(=CC=C1)C)NC(=O)CN2CCCC2=O
    2.2 Other Identifiers
    2.2.1 UNII
    1JK12GX30N
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Dm 9384

    2. Dm-9384

    3. N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide

    2.3.2 Depositor-Supplied Synonyms

    1. 77191-36-7

    2. N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide

    3. Translon

    4. Dm 9384

    5. Nefiracetam [inn]

    6. Motiva

    7. Dzl-221

    8. N-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamide

    9. 1-pyrrolidineacetamide, N-(2,6-dimethylphenyl)-2-oxo-

    10. Nefiracetam (translon)

    11. Nsc-759830

    12. 2-oxo-1-pyrrolidineaceto-2',6'-xylidide

    13. 1jk12gx30n

    14. Dm9384;dzl-221

    15. Ncgc00186006-01

    16. N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide

    17. Cas#77191-36-7

    18. Dsstox_cid_923

    19. Dsstox_rid_75870

    20. Dsstox_gsid_20923

    21. Dmppa

    22. Nefiracetamum

    23. Dm-9384

    24. Nefiracetamum [inn-latin]

    25. Smr001456240

    26. Cas-77191-36-7

    27. Ccris 6729

    28. Brn 6848330

    29. N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl]acetamide

    30. Unii-1jk12gx30n

    31. Nefiracetam, Solid

    32. Mfcd00209882

    33. Nefiracetam [mi]

    34. Nefiracetam [jan]

    35. Nefiracetam [mart.]

    36. Mls004774126

    37. Mls006010195

    38. Schembl135856

    39. Chembl260829

    40. Zinc3788

    41. Dtxsid2020923

    42. Dzl 221

    43. Chebi:135004

    44. Hms3261i16

    45. Hms3655n05

    46. Hms3884c18

    47. Pharmakon1600-01502315

    48. Bcp21371

    49. Cda19136

    50. Hy-b0340

    51. Tox21_113521

    52. Tox21_201916

    53. Tox21_303025

    54. Tox21_500447

    55. Dm9384

    56. Nsc759830

    57. S1969

    58. Akos015895083

    59. Tox21_113521_1

    60. Ab04796

    61. Ccg-213818

    62. Db13082

    63. Ks-5226

    64. Lp00447

    65. Nsc 759830

    66. Sdccgsbi-0633714.p001

    67. Ncgc00186006-02

    68. Ncgc00186006-03

    69. Ncgc00186006-04

    70. Ncgc00186006-11

    71. Ncgc00256487-01

    72. Ncgc00259465-01

    73. Ncgc00261132-01

    74. Ac-15655

    75. Ac-32883

    76. Db-056185

    77. Ft-0630853

    78. N0996

    79. Sw219212-1

    80. T72927

    81. Ab01274721-01

    82. Ab01274721_02

    83. Ab01274721_03

    84. 191n367

    85. A838998

    86. Sr-01000883754

    87. Q6039388

    88. Sr-01000883754-1

    89. 1-pyrrolidineacetamide,n-(2,6-dimethylphenyl)-2-oxo-

    90. Z79686019

    91. Dm-9384; Dzl-221; Dm9384; Dzl221; Dm 9384; Dzl 221

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 246.30 g/mol
    Molecular Formula C14H18N2O2
    XLogP31.4
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count3
    Exact Mass246.136827821 g/mol
    Monoisotopic Mass246.136827821 g/mol
    Topological Polar Surface Area49.4 Ų
    Heavy Atom Count18
    Formal Charge0
    Complexity320
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Nootropic Agents

    Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. (See all compounds classified as Nootropic Agents.)

    Central Nervous System Agents

    A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use. (From Gilman AG, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p252) (See all compounds classified as Central Nervous System Agents.)

    Neuroprotective Agents

    Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)

    Psychotropic Drugs

    A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents). (See all compounds classified as Psychotropic Drugs.)