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    Nefopam Hydrochloride

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    2D Structure
    Also known as: 23327-57-3, Nefopam hcl, Acupan, Fenazoxine hydrochloride, 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1h-benzo[f][1,4]oxazocine hydrochloride, Nefopam (hydrochloride)
    Molecular Formula
    C17H20ClNO
    Molecular Weight
    289.8  g/mol
    InChI Key
    CNNVSINJDJNHQK-UHFFFAOYSA-N
    FDA UNII
    685J48E13W
    Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p26)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine;hydrochloride
    2.1.2 InChI
    InChI=1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H
    2.1.3 InChI Key
    CNNVSINJDJNHQK-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN1CCOC(C2=CC=CC=C2C1)C3=CC=CC=C3.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    685J48E13W
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Acupan

    2. Ajan

    3. Fenazoxine

    4. Hydrochloride, Nefopam

    5. Nefopam

    6. Nefopam, Silentan

    7. Silentan Nefopam

    2.3.2 Depositor-Supplied Synonyms

    1. 23327-57-3

    2. Nefopam Hcl

    3. Acupan

    4. Fenazoxine Hydrochloride

    5. 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1h-benzo[f][1,4]oxazocine Hydrochloride

    6. Nefopam (hydrochloride)

    7. Nefopam Hydrochloride [usan]

    8. 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1h-2,5-benzoxazocine Hydrochloride

    9. 3,4,5,6-tetrahydro-5-methyl-1-phenyl-1h-2,5-benzoxazocine Hydrochloride

    10. 1h-2,5-benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, Hydrochloride (1:1)

    11. 685j48e13w

    12. Nsc-757856

    13. 23327-57-3 (hcl)

    14. 5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine;hydrochloride

    15. 1h-2,5-benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, Hydrochloride

    16. Dsstox_cid_25441

    17. Dsstox_rid_80882

    18. Dsstox_gsid_45441

    19. Nefopam Hydrochloride (usan)

    20. Leoplexamin

    21. Pallopikeron

    22. Lenipan

    23. Sinalgico

    24. Oxadol

    25. Ajan

    26. Smr000514529

    27. Sr-01000388442

    28. Unii-685j48e13w

    29. Prestwick_351

    30. Einecs 245-585-5

    31. Nefopan Hydrochloride

    32. Acupan (tn)

    33. 69319-31-9

    34. Ncgc00016778-01

    35. R 738

    36. Cas-23327-57-3

    37. Mls001210851

    38. Mls001240198

    39. Mls002222204

    40. Schembl122057

    41. Chembl1407915

    42. Dtxsid7045441

    43. Hms1568n19

    44. Nefopam Hydrochloride [mi]

    45. Bcp13749

    46. Hy-b1057

    47. Tox21_110606

    48. Mfcd00012750

    49. S4180

    50. Nefopam Hydrochloride [mart.]

    51. 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1h-benzo[f][1,4]oxazocinehydrochloride

    52. Akos015845828

    53. Nefopam Hydrochloride [who-dd]

    54. Tox21_110606_1

    55. Ccg-220229

    56. Cs-4579

    57. Nsc 757856

    58. Nefopam Hydrochloride, >=98% (hplc)

    59. Ncgc00094906-06

    60. Ac-11999

    61. As-13286

    62. Cas#23327-57-3

    63. Db-046129

    64. Ft-0630499

    65. N1169

    66. C74201

    67. D05133

    68. Sr-01000388442-1

    69. Sr-01000388442-4

    70. Q27264216

    71. Fenazoxine Hydrochloride; Lenipan; Leoplexamin; Nefopam Hcl

    72. Nefopam Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    73. 5-benzoxazocine,5-methyl-1-phenyl-3,4,5,6-tetrahydro-1h-hydrochloride

    74. 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1h-benzo[f][1,4]oxazocine Hcl

    75. 1h-2,5-benzoxazocine, 5-methyl-1-phenyl-3,4,5,6-tetrahydro-, Hydrochloride

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 289.8 g/mol
    Molecular Formula C17H20ClNO
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count1
    Exact Mass289.1233420 g/mol
    Monoisotopic Mass289.1233420 g/mol
    Topological Polar Surface Area12.5 Ų
    Heavy Atom Count20
    Formal Charge0
    Complexity274
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Analgesics, Non-Narcotic

    A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)