Please Wait
Applying Filters...
menu
    • menu
    Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

    Virtual Booth

    Contact Supplier

    Jai Radhe Sales is your partner for all your sourcing needs.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    Egis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

    Virtual Booth

    Contact Supplier

    Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    Menu

    Nicergoline

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    GLOBAL SALES INFORMATION

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 4,655Xls

    Filters

    clear-filterReset all filters
    2D Structure
    Also known as: 27848-84-6, Nimergoline, Ergobel, Nicergolinum, Nicotergoline, Sermion
    Molecular Formula
    C24H26BrN3O3
    Molecular Weight
    484.4  g/mol
    InChI Key
    YSEXMKHXIOCEJA-FVFQAYNVSA-N
    FDA UNII
    JCV8365FWN
    An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It may ameliorate cognitive deficits in CEREBROVASCULAR DISORDERS.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(6aR,9R,10aS)-10a-methoxy-4,7-dimethyl-6a,8,9,10-tetrahydro-6H-indolo[4,3-fg]quinolin-9-yl]methyl 5-bromopyridine-3-carboxylate
    2.1.2 InChI
    InChI=1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1
    2.1.3 InChI Key
    YSEXMKHXIOCEJA-FVFQAYNVSA-N
    2.1.4 Canonical SMILES
    CN1CC(CC2(C1CC3=CN(C4=CC=CC2=C34)C)OC)COC(=O)C5=CC(=CN=C5)Br
    2.1.5 Isomeric SMILES
    CN1C[C@@H](C[C@]2([C@H]1CC3=CN(C4=CC=CC2=C34)C)OC)COC(=O)C5=CC(=CN=C5)Br
    2.2 Other Identifiers
    2.2.1 UNII
    JCV8365FWN
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Circo Maren

    2. Circo-maren

    3. Ergobel

    4. F.i. 6714

    5. Fisifax

    6. Nicergobeta

    7. Nicergolin Atid

    8. Nicergolin Lindo

    9. Nicergolin Neuraxpharm

    10. Nicergolin Ratiopharm

    11. Nicergolin Teva

    12. Nicergolin Von Ct

    13. Nicergolin-neuraxpharm

    14. Nicergolin-ratiopharm

    15. Nicergolin-teva

    16. Nicerium

    17. Nicotergoline

    18. Nimergoline

    19. Sermion

    20. Von Ct, Nicergolin

    2.3.2 Depositor-Supplied Synonyms

    1. 27848-84-6

    2. Nimergoline

    3. Ergobel

    4. Nicergolinum

    5. Nicotergoline

    6. Sermion

    7. Cergodum

    8. Duracebrol

    9. Nicergolent

    10. Vasospan

    11. Circo-maren

    12. Nimergoline Base

    13. Dilasenil

    14. Ergotop

    15. Nilogrin

    16. Memoq

    17. Sermion (tn)

    18. 10-methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate

    19. Jcv8365fwn

    20. Chebi:31902

    21. Nicergolin [german]

    22. Nicergolina [dcit]

    23. Nsc-150531

    24. ((6ar,9r,10as)-10a-methoxy-4,7-dimethyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methyl 5-bromonicotinate

    25. Fi-6714

    26. Rp 19651

    27. Ncgc00017259-04

    28. Nicergolinum [inn-latin]

    29. Nicergolina

    30. Nicergolin

    31. Dsstox_cid_25607

    32. Dsstox_rid_81000

    33. Dsstox_gsid_45607

    34. [(2s,4r,7r)-2-methoxy-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraen-4-yl]methyl 5-bromopyridine-3-carboxylate

    35. [(6ar,9r,10as)-10a-methoxy-4,7-dimethyl-6a,8,9,10-tetrahydro-6h-indolo[4,3-fg]quinoline-9-yl]methyl 5-bromopyridine-3-carboxylate

    36. Cas-27848-84-6

    37. Fi 6714

    38. Sr-01000597616

    39. Einecs 248-694-6

    40. Unii-jcv8365fwn

    41. Nsc 150531

    42. Brn 4828393

    43. 1-methyl-lumilysergol 8-(5-bromonicotinate) 10-methyl Ether

    44. Nicergoline,(s)

    45. (+)-10-methoxy-1,6-dimethylergoline-8-beta-methanol 5-bromonicotinate

    46. 10-methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate (ester)

    47. Nicergoline [usan:inn:ban:jan]

    48. 10-methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat) [german]

    49. 8-beta-((5-bromonicotinoyloxy)methyl)-1,6-dimethyl-10-alpha-methoxyergoline

    50. Nicergoline- Bio-x

    51. Mfcd00869626

    52. 10-methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyrindinecarboxylate (ester)

    53. Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester)

    54. Spectrum_001370

    55. Nicergoline [mi]

    56. 10-methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat)

    57. Prestwick0_000147

    58. Prestwick1_000147

    59. Prestwick2_000147

    60. Prestwick3_000147

    61. Spectrum2_001414

    62. Spectrum3_001933

    63. Spectrum4_000440

    64. Spectrum5_001352

    65. Nicergoline [inn]

    66. Nicergoline [jan]

    67. 5-bromonicotinic Acid 10-methoxy-1,6-dimethylergoline-8-methyl Ester

    68. Nicergoline [usan]

    69. Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester)

    70. Ergoline-8beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester)

    71. Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, (8beta)-, 5-bromo-3-pyridinecarboxylate (ester)

    72. Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)-

    73. Nicergoline [mart.]

    74. Schembl22964

    75. Bspbio_000254

    76. Bspbio_003533

    77. Kbiogr_000800

    78. Kbioss_001850

    79. Nicergoline [who-dd]

    80. Divk1c_000124

    81. Spectrum1501133

    82. Spbio_001488

    83. Spbio_002193

    84. Bpbio1_000280

    85. Chembl1372950

    86. Dtxsid7045607

    87. Hms500g06

    88. Kbio1_000124

    89. Kbio2_001850

    90. Kbio2_004418

    91. Kbio2_006986

    92. Kbio3_002787

    93. Nicergoline (jp17/usan/inn)

    94. Nicergoline For System Suitability

    95. Ninds_000124

    96. Hms1568m16

    97. Hms1923o09

    98. Hms2089i03

    99. Hms2092f07

    100. Hms2095m16

    101. Hms3712m16

    102. Hms3886c03

    103. Nicergoline [ep Monograph]

    104. Nicergoline For Peak Identification

    105. Pharmakon1600-01501133

    106. 4-oxazolecarboxylicacid, 5-methyl-

    107. Ex-a4135

    108. Hy-b0702

    109. Zinc3873817

    110. Tox21_110810

    111. Ccg-39032

    112. Nsc757853

    113. S4797

    114. Akos005067888

    115. Akos015969107

    116. Tox21_110810_1

    117. Db00699

    118. Nicergoline 1.0 Mg/ml In Acetonitrile

    119. Nsc-757853

    120. Idi1_000124

    121. Qtl1_000060

    122. Ncgc00017259-03

    123. Ncgc00017259-05

    124. Ncgc00017259-07

    125. Ncgc00024678-02

    126. Ncgc00024678-03

    127. As-12239

    128. Bn166697

    129. Sbi-0051652.p002

    130. N0904

    131. D01290

    132. T72213

    133. Ab00052214-04

    134. Ab00052214_05

    135. 848n846

    136. A853601

    137. Sr-05000001751

    138. J-016896

    139. Nicergoline, Analytical Standard, For Drug Analysis

    140. Q2623398

    141. Sr-01000597616-1

    142. Sr-01000597616-2

    143. Sr-05000001751-1

    144. Brd-k76810206-001-05-7

    145. Brd-k76810206-001-06-5

    146. Nicergoline, European Pharmacopoeia (ep) Reference Standard

    147. (8beta)-10-methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyridinecarboxylate (ester)

    148. [(8r,10s)-10-methoxy-1,6-dimethylergolin-8-yl]methyl 5-bromopyridine-3-carboxylate

    149. 10-methoxy-1,6-dimethylergoline-8.beta.-methanol 5-bromonicotinate (ester)

    150. Nicergoline For Peak Identification, European Pharmacopoeia (ep) Reference Standard

    151. Nicergoline For System Suitability, European Pharmacopoeia (ep) Reference Standard

    152. ((6ar,9r,10as)-10a-methoxy-4,7-dimethyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methyl5-bromonicotinate

    153. [(6ar,9r,10as)-10a-methoxy-4,7-dimethyl-6a,8,9,10-tetrahydro-6h-indolo[4,3-fg]quinolin-9-yl]methyl 5-bromopyridine-3-carboxylate

    154. 5-bromopyridine-3-carboxylic Acid [(8r,10s)-10-methoxy-1,6-dimethylergolin-8-yl]methyl Ester

    155. Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, (8.beta.)-, 5-bromo-3-pyridinecarboxylate (ester)

    156. Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-,5-bromo-3-pyridinecarboxylate (ester), (8b)-

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 484.4 g/mol
    Molecular Formula C24H26BrN3O3
    XLogP33.2
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count5
    Exact Mass483.11575 g/mol
    Monoisotopic Mass483.11575 g/mol
    Topological Polar Surface Area56.6 Ų
    Heavy Atom Count31
    Formal Charge0
    Complexity681
    Isotope Atom Count0
    Defined Atom Stereocenter Count3
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    For the treatment of senile dementia, migraines of vascular origin, transient ischemia, platelet hyper-aggregability, and macular degeneration.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Nicergoline is a potent vasodilator (improves brain blood flow). On the cerebral level it prompts a lowering of vascular resistance, an increase in arterial flow and stimulates the use of oxygen and glucose. Nicergoline also improves blood circulation in the lungs and limbs and has been shown to inhibit blood platelet aggregation.

    5.2 MeSH Pharmacological Classification

    Adrenergic alpha-Antagonists

    Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. (See all compounds classified as Adrenergic alpha-Antagonists.)

    Nootropic Agents

    Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. (See all compounds classified as Nootropic Agents.)

    Vasodilator Agents

    Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

    5.3 ATC Code

    C - Cardiovascular system

    C04 - Peripheral vasodilators

    C04A - Peripheral vasodilators

    C04AE - Ergot alkaloids

    C04AE02 - Nicergoline

    5.4 Mechanism of Action

    Nicergoline acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. Therefore the mechanism of Nicergoline is to increase vascular circulation in the brain, thereby enhancing the transmission of nerve signals across the nerve fibres, which secrete acetylcholine as a neural transmitter.