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2D Structure
Also known as: 2011-67-8, 1-methylnitrazepam, Elimin, Erimin, Methylnitrazepam, 1,3-dihydro-1-methyl-7-nitro-5-phenyl-2h-1,4-benzodiazepin-2-one
Molecular Formula
C16H13N3O3
Molecular Weight
295.29  g/mol
InChI Key
GWUSZQUVEVMBPI-UHFFFAOYSA-N
FDA UNII
4532264KW6

1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one
2.1.2 InChI
InChI=1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
2.1.3 InChI Key
GWUSZQUVEVMBPI-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1C(=O)CN=C(C2=C1C=CC(=C2)[N+](=O)[O-])C3=CC=CC=C3
2.2 Other Identifiers
2.2.1 UNII
4532264KW6
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-methyl-7-nitro-5-phenyl-1,3-dihydro-2h-1,4- Benzodiazepin-2-one

2. Hypnon

3. S-1530

2.3.2 Depositor-Supplied Synonyms

1. 2011-67-8

2. 1-methylnitrazepam

3. Elimin

4. Erimin

5. Methylnitrazepam

6. 1,3-dihydro-1-methyl-7-nitro-5-phenyl-2h-1,4-benzodiazepin-2-one

7. Nimetazepamum

8. Ro 5-3453

9. S 1530

10. 1-methyl-5-phenyl-7-nitro-1,3-dihydro-2h-1,4-benzodiazepin-2-one

11. 1-methyl-7-nitro-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one

12. 1-methyl-7-nitro-5-phenyl-3h-1,4-benzodiazepin-2-one

13. S-1530

14. 2h-1,4-benzodiazepin-2-one, 1,3-dihydro-1-methyl-7-nitro-5-phenyl-

15. Chebi:31912

16. Ncgc00164577-01

17. 4532264kw6

18. Dsstox_cid_3369

19. Dsstox_rid_76997

20. Dsstox_gsid_23369

21. Nimetazepam [inn:jan]

22. Nimetazepamum [inn-latin]

23. Smr000238177

24. Cas-2011-67-8

25. Einecs 217-931-5

26. Brn 0759813

27. Dormalon

28. Dea No. 2837

29. Unii-4532264kw6

30. Erimin (tn)

31. Nitrazepam, Methylated

32. Nimetazepam (jan/inn)

33. Nimetazepam [mi]

34. Nimetazepam [inn]

35. Nimetazepam [jan]

36. Nimetazepam [mart.]

37. Schembl79886

38. Nimetazepam [who-dd]

39. Mls000759521

40. Mls001424150

41. Chembl13341

42. Dtxsid6023369

43. Hms2051l16

44. Hms3393l16

45. Zinc3831205

46. Tox21_112205

47. Akos030239804

48. Tox21_112205_1

49. Ccg-101044

50. Nc00294

51. Ncgc00164577-02

52. D01593

53. 011n678

54. A814257

55. Q6149812

56. 1-methyl-7-nitro-5-phenyl-2,3-dihydro-1h-1,4-benzodiazepin-2-one

57. 7-nitro-1,3-dihydro-1-methyl-5-phenyl-2h-1,4-benzodiazepin-2-one

58. Nimetazepam Solution, 1.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 295.29 g/mol
Molecular Formula C16H13N3O3
XLogP32.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass295.09569129 g/mol
Monoisotopic Mass295.09569129 g/mol
Topological Polar Surface Area78.5 Ų
Heavy Atom Count22
Formal Charge0
Complexity480
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anticonvulsants

Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)


GABA Modulators

Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)


Hypnotics and Sedatives

Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)


Anti-Anxiety Agents

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)


4.2 ATC Code

N - Nervous system

N05 - Psycholeptics

N05C - Hypnotics and sedatives

N05CD - Benzodiazepine derivatives

N05CD15 - Nimetazepam