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    Nipradilol

    ACTIVE PHARMA INGREDIENTS

    PharmaCompass
    Xls

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    2D Structure
    Also known as: Nipradolol, 81486-22-8, Hypadil, Hypadil (tn), K 351, Fvm336i71y
    Molecular Formula
    C15H22N2O6
    Molecular Weight
    326.34  g/mol
    InChI Key
    OMCPLEZZPVJJIS-UHFFFAOYSA-N
    FDA UNII
    FVM336I71Y
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [8-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3,4-dihydro-2H-chromen-3-yl] nitrate
    2.1.2 InChI
    InChI=1S/C15H22N2O6/c1-10(2)16-7-12(18)8-21-14-5-3-4-11-6-13(23-17(19)20)9-22-15(11)14/h3-5,10,12-13,16,18H,6-9H2,1-2H3
    2.1.3 InChI Key
    OMCPLEZZPVJJIS-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C)NCC(COC1=CC=CC2=C1OCC(C2)O[N+](=O)[O-])O
    2.2 Other Identifiers
    2.2.1 UNII
    FVM336I71Y
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 3,4-dihydro-8-(2-hydroxy-3--isopropylaminopropoxy)-3-nitroxy-2h-1-benzopyran

    2. K 351

    3. K-351

    2.3.2 Depositor-Supplied Synonyms

    1. Nipradolol

    2. 81486-22-8

    3. Hypadil

    4. Hypadil (tn)

    5. K 351

    6. Fvm336i71y

    7. 8-(2-hydroxy-3-(isopropylamino)propoxy)chroman-3-yl Nitrate

    8. 8-(2-hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate

    9. [8-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3,4-dihydro-2h-chromen-3-yl] Nitrate

    10. Hypadil; K 351; Kt 210; Nipradilo

    11. Nipradilolum [latin]

    12. Nipradilolum

    13. Nipradilol [inn:jan]

    14. Ccris 2515

    15. Brn 3566879

    16. Unii-fvm336i71y

    17. Nipranol

    18. 8-(2-hydroxy-3-(isopropylamino)propoxy)-3-chromanyl Nitrat

    19. Nipradilol [mi]

    20. 8-(2-hydroxy-3-(isopropylamino)propoxy)-3-chromanol 3-nitrate

    21. Nipradilol (jan/inn)

    22. Nipradilol [inn]

    23. Nipradilol [jan]

    24. Nipradilol [inci]

    25. K-351

    26. 3,4-dihydro-8-(2-hydroxy-3-isopropylamino)propoxy-3-nitroxy-2h-1-benzopyran

    27. Nipradilol [mart.]

    28. 3,4-dihydro-8-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-2h-1-benzopyran-3-ol 3-nitrate

    29. 3,4-dihydro-8-(2-hydroxy-3-(isopropylamino)propoxy)-2h-1-benzopyran-3-ol 3-nitrate

    30. Nipradolol [who-dd]

    31. Schembl48884

    32. Chembl155622

    33. Chebi:31682

    34. Dtxsid30868615

    35. Bcp04466

    36. Kt-210

    37. Akos016014067

    38. 2h-1-benzopyran-3-ol, 3,4-dihydro-8-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, 3-nitrate

    39. Ft-0630894

    40. D01691

    41. L013397

    42. Q15634005

    43. 3,4-dihydro-8-(2-hydroxy-3-isopropylaminopropoxy)-3-nitroxy-2h-1-benzopyran

    44. 3-nitroxy-8-[(2-hydroxy-3-isopropylamino)propoxy]-3,4(2h)-dihydro-1-benzopyran

    45. 8-[2-hydroxy-3-(isopropylamino)propoxy]-3,4-dihydro-2h-chromen-3-yl Nitrate #

    46. 8-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}-3,4-dihydro-2h-1-benzopyran-3-yl Nitrate

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 326.34 g/mol
    Molecular Formula C15H22N2O6
    XLogP32
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count7
    Exact Mass326.14778643 g/mol
    Monoisotopic Mass326.14778643 g/mol
    Topological Polar Surface Area106 Ų
    Heavy Atom Count23
    Formal Charge0
    Complexity376
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Vasodilator Agents

    Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

    Adrenergic alpha-Antagonists

    Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. (See all compounds classified as Adrenergic alpha-Antagonists.)

    Adrenergic beta-Antagonists

    Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)