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    Technical details about Nisoxetine, learn more about the structure, uses, toxicity, action, side effects and more

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    Nisoxetine

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    2D Structure
    Also known as: 53179-07-0, 3-(2-methoxyphenoxy)-n-methyl-3-phenylpropan-1-amine, Compound 89218, 3-(2-methoxyphenoxy)-n-methyl-3-phenylpropylamine, 57226-61-6, Dl-n-methyl-3-(o-methoxyphenoxy)-n-methyl-3-phenylpropylamine
    Molecular Formula
    C17H21NO2
    Molecular Weight
    271.35  g/mol
    InChI Key
    ITJNARMNRKSWTA-UHFFFAOYSA-N
    FDA UNII
    17NV064B2D
    Nisoxetine is a selective norepinephrine reuptake inhibitor (SNRI) developed in the 1970s. It was originally investigated as an antidepressant but has no current clinical applications aside from being a research standard SNRI. It has been used to research obesity and energy balance, and exerts some local analgesia effects.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine
    2.1.2 InChI
    InChI=1S/C17H21NO2/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2/h3-11,15,18H,12-13H2,1-2H3
    2.1.3 InChI Key
    ITJNARMNRKSWTA-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CNCCC(C1=CC=CC=C1)OC2=CC=CC=C2OC
    2.2 Other Identifiers
    2.2.1 UNII
    17NV064B2D
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 3-(2-methoxyphenoxy)-n-methyl-3-phenylpropylamine

    2. 3-(o-methoxyphenoxy)-n-methyl-3-phenylpropylamine

    3. Dl-n-methyl-3-(o-methoxyphenoxy)-n-methyl-3-phenylpropylamine

    4. Lilly 135252

    5. Lilly 94939

    6. Ly 135252

    7. Ly 94939

    8. Ly-135252

    9. N-methyl-gamma-(2-methylphenoxy)phenylpropanolamine

    10. Nisoxetine Hydrochloride

    11. Nisoxetine Hydrochloride, (+-)-isomer

    12. Nisoxetine, (+-)-isomer

    2.3.2 Depositor-Supplied Synonyms

    1. 53179-07-0

    2. 3-(2-methoxyphenoxy)-n-methyl-3-phenylpropan-1-amine

    3. Compound 89218

    4. 3-(2-methoxyphenoxy)-n-methyl-3-phenylpropylamine

    5. 57226-61-6

    6. Dl-n-methyl-3-(o-methoxyphenoxy)-n-methyl-3-phenylpropylamine

    7. Nsc-283481

    8. 3-(o-methoxyphenoxy)-n-methyl-3-phenylpropylamine

    9. N-methyl-gamma-(2-methylphenoxy)phenylpropanolamine

    10. Chembl295467

    11. Chebi:73410

    12. 17nv064b2d

    13. Benzenepropanamine, Gamma-(2-methoxyphenoxy)-n-methyl-

    14. Compound 89218; Nsc 283481

    15. Ncgc00015715-04

    16. Nisoxetine Inhibitor

    17. Dsstox_cid_25175

    18. Dsstox_rid_80724

    19. Dsstox_gsid_45175

    20. Nisoxetina

    21. Nisoxetinum

    22. Nisoxetine [usan:inn]

    23. Cas-53179-07-0

    24. Ly-94939

    25. Unii-17nv064b2d

    26. Nsc 283481

    27. Ly 94939

    28. Nisoxetine [inn]

    29. Antioxidant1425

    30. Nisoxetine (usan/inn)

    31. Prestwick0_000910

    32. Prestwick1_000910

    33. Prestwick2_000910

    34. Prestwick3_000910

    35. Nisoxetine [usan]

    36. Lopac0_000901

    37. Bspbio_000760

    38. Compound-89218

    39. Schembl124289

    40. Spbio_002959

    41. Bpbio1_000836

    42. Gtpl4637

    43. Dtxsid0045175

    44. Bdbm22417

    45. Hms2089k13

    46. Tox21 110203

    47. Tox21_110203

    48. Nsc283481

    49. Pdsp1_000507

    50. Pdsp2_000505

    51. Tox21_110203_1

    52. Ccg-204983

    53. Db09186

    54. Sdccgsbi-0050876.p002

    55. Ncgc00015715-03

    56. Ncgc00015715-05

    57. Ncgc00015715-06

    58. Ncgc00015715-08

    59. Ncgc00015715-15

    60. Ncgc00024945-02

    61. Ncgc00024945-03

    62. As-16468

    63. Ab00514644

    64. D05173

    65. Ab00514644-07

    66. N-methyl 3(o-methoxyphenoxy)-3-phenylpropylamine

    67. N-methyl 3-(o-methoxyphenoxy)-3-phenylpropylamine

    68. Q906885

    69. [3-(2-methoxyphenoxy)-3-phenylpropyl](methyl)amine

    70. N-methyl-3-phenyl-3-(o-methoxyphenoxy)-propylamine

    71. Brd-a95696066-003-03-9

    72. Brd-a95696066-003-06-2

    73. (+/-)-3-(o-methoxyphenoxy)-n-methyl-3-phenylpropylamine

    74. Benzenepropanamine, .gamma.-(2-methoxyphenoxy)-n-methyl-, (+/-)-

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 271.35 g/mol
    Molecular Formula C17H21NO2
    XLogP33.1
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count7
    Exact Mass271.157228913 g/mol
    Monoisotopic Mass271.157228913 g/mol
    Topological Polar Surface Area30.5 Ų
    Heavy Atom Count20
    Formal Charge0
    Complexity253
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1