1. Alodorm
2. Dormalon
3. Dormo-puren
4. Eatan
5. Imadorm
6. Imeson
7. Mogadon
8. Nitrazadon
9. Nitrazep
10. Nitrazepam Al
11. Nitrazepam Neuraxpharm
12. Nitrazepam-neuraxpharm
13. Nitrodiazepam
14. Novanox
15. Radedorm
16. Remnos
17. Rhoxal Nitrazepam
18. Rhoxal-nitrazepam
19. Serenade
20. Somnite
1. Benzalin
2. 146-22-5
3. Neozepam
4. Imeson
5. Mogadon
6. Remnos
7. Neuchlonic
8. Apodorm
9. Calsmin
10. Eunoctin
11. Imesont
12. Nitrados
13. Radedorm
14. Sonebon
15. Trazenin
16. Hipnax
17. Hipsal
18. Nelmat
19. Surem
20. Epibenzalin
21. Epinelbon
22. Nitrenpax
23. Somitran
24. Sonnolin
25. Unisomnia
26. Cerson
27. Dumolid
28. Nelbon
29. Paxisyn
30. Pelson
31. Relact
32. N-desmethylnimetazepam
33. Persopit
34. Gerson
35. Ibrovek
36. Eatan
37. Dormin-5
38. Nitrazepamum
39. 1,3-dihydro-7-nitro-5-phenyl-2h-1,4-benzodiazepin-2-one
40. Ro 4-5360
41. Mogadone
42. Magadon
43. Megadon
44. Mogadan
45. Ro 5-3059
46. Nitrazepamum [inn-latin]
47. 7-nitro-5-phenyl-2,3-dihydro-1h-1,4-benzodiazepin-2-one
48. La 1
49. Nsc-58775
50. 7-nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
51. 7-nitro-1,3-dihydro-5-phenyl-2h-1,4-benzodiazepin-2-one
52. 2h-1,4-benzodiazepin-2-one, 1,3-dihydro-7-nitro-5-phenyl-
53. S 2000
54. 7-nitro-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one
55. 2,3-dihydro-7-nitro-5-phenyl-1h-1,4-benzodiazepin-2-on
56. Dormo-puren
57. N05cd02
58. Mitidin
59. 9clv70w7hs
60. Chembl13209
61. Eatan N
62. Chebi:7581
63. Somnite
64. Nsc58775
65. Ro-45360
66. Ro-53059
67. Ncgc00159358-02
68. 2,3-dihydro-7-nitro-5-phenyl-1h-1,4-benzodiazepin-2-one
69. Calsamin
70. Eunoktin
71. Ipersed
72. Nitravet
73. Nitrempax
74. Noctesed
75. Pacisyn
76. Somnased
77. Somnibel
78. Ro-4-5360
79. Ro-5-3059
80. Dsstox_cid_3372
81. La 1 (van)
82. Dormicum (anticonvulsant)
83. Dsstox_rid_77000
84. Dsstox_gsid_23372
85. 7-nitro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
86. Nitrazepam [usan:inn:ban:jan]
87. Nitrazepam (tn)
88. Benzalin (tn)
89. Cas-146-22-5
90. Smr000058302
91. Ccris 1931
92. Einecs 205-665-2
93. Nsc 58775
94. Unii-9clv70w7hs
95. Brn 0757185
96. Dea No. 2834
97. Isopropylacetate/nitrazepam
98. Ro 53-60
99. Nitrazepam [mi]
100. Nitrazepam [inn]
101. Nitrazepam [jan]
102. Nitrazepam [usan]
103. Chemdiv1_022312
104. Nitrazepam [mart.]
105. Nitrazepam [who-dd]
106. Nitrazepam [who-ip]
107. Oprea1_476234
108. Schembl35202
109. 5-24-04-00344 (beilstein Handbook Reference)
110. Mls001304053
111. Mls001424061
112. Dtxsid5023372
113. Nitrazepam (jp17/usan/inn)
114. Hms650g04
115. Kjonhkayojnzec-uhfffaoysa-
116. Nitrazepam [ep Monograph]
117. 1, 3-dihydro-7-nitro-5-phenyl-2h-1,4-benzodiazepin-2-one
118. Hms2051f19
119. Hms2272g03
120. Hms3393f19
121. 7-nitro-1,4-benzodiazepin-2-one
122. Nitrazepam Methanol Solution
123. Nitrazepamum [who-ip Latin]
124. Zinc4311748
125. Tox21_111601
126. Bdbm50020856
127. Pdsp1_000120
128. Pdsp2_000120
129. Stk806322
130. Akos002254707
131. Nitrazepam 0.1 Mg/ml In Acetonitrile
132. Nitrazepam 1.0 Mg/ml In Acetonitrile
133. Tox21_111601_1
134. Wln: T67 Gmv Jn Ihj Cnw Kr
135. Ab02342
136. Ac-4537
137. Ccg-100977
138. Db01595
139. Nc00227
140. Ncgc00159358-03
141. 2h-1, 1,3-dihydro-7-nitro-5-phenyl-
142. 7-nitro-5-phenyl-2,4-benzodiazepin-2-one
143. Db-042832
144. C07487
145. D00531
146. 146n225
147. A808471
148. Q410078
149. 7-nitro-5-phenyl-1h-benzo[e][1,4]diazepin-2(3h)-one
150. Nitrazepam, British Pharmacopoeia (bp) Reference Standard
151. Nitrazepam, European Pharmacopoeia (ep) Reference Standard
152. (z)-7-nitro-5-phenyl-1h-benzo[e][1,4]diazepin-2(3h)-one
153. 1,3-dihydro-7-nitro-5-phenyl-2h-1,4-benzodiazepine-2-one
154. 7-nitro-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one #
155. Nitrazepam Solution, 1.0 Mg/ml In Acetonitrile, Ampule Of 1 Ml, Certified Reference Material
| Molecular Weight | 281.27 g/mol |
|---|---|
| Molecular Formula | C15H11N3O3 |
| XLogP3 | 2.2 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 1 |
| Exact Mass | 281.08004122 g/mol |
| Monoisotopic Mass | 281.08004122 g/mol |
| Topological Polar Surface Area | 87.3 Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 452 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Used to treat short-term sleeping problems (insomnia), such as difficulty falling asleep, frequent awakenings during the night, and early-morning awakening.
Nitrazepam is a type of benzodiazepine drug. It is a powerful hypnotic drug which possesses strong sedative, anxiolytic, amnestic, anticonvulsant, and skeletal muscle relaxant properties. Nitrazepam shortens the time required to fall asleep and lengthens the duration of sleep. It is also useful for the management of myoclonic seizures.
Anti-Anxiety Agents
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)
GABA Modulators
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)
Hypnotics and Sedatives
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)
Anticonvulsants
Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)
N05CD02
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
N - Nervous system
N05 - Psycholeptics
N05C - Hypnotics and sedatives
N05CD - Benzodiazepine derivatives
N05CD02 - Nitrazepam
Absorption
Bioavailability is 53-94% following oral administration.
15-38 hours (mean elimination half life 26 hours).
Nitrazepam belongs to a group of medicines called benzodiazepines. This drug affects central benzodiazepine receptors, which are associated with inhibitory GABA (gamma amino butyric acid)receptors, leading to enhanced GABA binding activity. GABA is a major neurotransmitter in the brain, which causes somnolence, relaxation of muscles, a decrease in anxiety and general central nervous system depression. Nitrazepam has anticonvulsant properties that may be attributed to its ability to bind to voltage-dependent sodium channels. Sustained repetitive firing seems to be limited by benzodiazepines effect of slowing recovery of sodium channels from inactivation.
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