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    Nordazepam

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    GLOBAL SALES INFORMATION

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 818Xls

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    2D Structure
    Also known as: Nordiazepam, Desmethyldiazepam, Dealkylprazepam, Norprazepam, N-desmethyldiazepam, 1088-11-5
    Molecular Formula
    C15H11ClN2O
    Molecular Weight
    270.71  g/mol
    InChI Key
    AKPLHCDWDRPJGD-UHFFFAOYSA-N
    FDA UNII
    67220MCM01
    An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    7-chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
    2.1.2 InChI
    InChI=1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)
    2.1.3 InChI Key
    AKPLHCDWDRPJGD-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1C(=O)NC2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3
    2.2 Other Identifiers
    2.2.1 UNII
    67220MCM01
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Calmday

    2. Dealkylprazepam

    3. Demethyldiazepam

    4. Deoxydemoxepam

    5. Desmethyldiazepam

    6. N Desalkylhalazepam

    7. N Descyclopropylmethyl Prazepam

    8. N Descyclopropylmethylprazepam

    9. N Destrifluoroethylhalazepam

    10. N-desalkylhalazepam

    11. N-descyclopropylmethyl-prazepam

    12. N-descyclopropylmethylprazepam

    13. N-destrifluoroethylhalazepam

    14. Nordaz

    15. Nordiazepam

    16. Norprazepam

    17. Ro 5 2180

    18. Ro 5-2180

    19. Ro 52180

    20. Tranxilium N

    21. Vegesan

    2.3.2 Depositor-Supplied Synonyms

    1. Nordiazepam

    2. Desmethyldiazepam

    3. Dealkylprazepam

    4. Norprazepam

    5. N-desmethyldiazepam

    6. 1088-11-5

    7. Calmday

    8. N-demethyldiazepam

    9. 1-demethyldiazepam

    10. N-deoxydemoxepam

    11. Madar

    12. N1-desmethyldiazepam

    13. Demethyldiazepam

    14. Desalkylprazepam

    15. Demadar

    16. Praxadium

    17. Stilny

    18. Nordazepamum

    19. Ro 5-2180

    20. Dmdz

    21. N-deoxydemoxapam

    22. Nordazepam Civ

    23. Nordazepam [inn]

    24. 7-chloro-1,3-dihydro-5-phenyl-2h-1,4-benzodiazepin-2-one

    25. N-descyclopropylmethylprazepam

    26. 7-chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one

    27. A 101

    28. A101

    29. 7-chloro-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one

    30. 2h-1,4-benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-

    31. Nsc 46078

    32. Nsc-46078

    33. Chembl523

    34. Nsc-631619

    35. Ndz

    36. Vegesan

    37. 2h-1,4-benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl-

    38. Chebi:111762

    39. Nordazepam (inn)

    40. Nsc631619

    41. 67220mcm01

    42. Ndd

    43. Ncgc00168263-01

    44. Nordaz

    45. 7-chloro-1,3-dihydro-5-phenyl-(2h)-1,4-benzodiazepin-2-one

    46. 7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

    47. Lomax

    48. Sopax

    49. Nordazepamum [inn-latin]

    50. Ccris 9181

    51. Einecs 214-123-4

    52. Brn 0751823

    53. Desoxydemoxepam

    54. Dea No. 2838

    55. Unii-67220mcm01

    56. Calmday (tn)

    57. Ro 52180

    58. 7-chlor-2,3-dihydro-5-phenyl-1h-1,4-benzodiazepin-2-on

    59. Diazepam-m N-desmethyl

    60. Diazepam Ep Impurity A

    61. Nordazepam [mi]

    62. Nordazepam (nordiazepam)

    63. Chemdiv1_028362

    64. Nordazepam [mart.]

    65. Mixcom6_000554

    66. Dsstox_cid_28926

    67. Dsstox_rid_83192

    68. Nordazepam [who-dd]

    69. Dsstox_gsid_49000

    70. Oprea1_578139

    71. Schembl78453

    72. 5-24-04-00291 (beilstein Handbook Reference)

    73. Mls001173623

    74. Divk1c_000979

    75. Dtxsid2049000

    76. Nordazepam Civ [usp-rs]

    77. Hms503c19

    78. Hms667j04

    79. Kbio1_000979

    80. Ninds_000979

    81. Hms2272b05

    82. Nsc46078

    83. Zinc1249069

    84. Tox21_113493

    85. Bdbm50027835

    86. Stk560158

    87. Desmethyldiazepam, Analytical Standard

    88. Wln: T67 Gmv Jn Ihj Cg Kr

    89. Akos000636746

    90. Akos005486646

    91. Db14028

    92. Idi1_000979

    93. Diazepam Impurity A [ep Impurity]

    94. Smr000238153

    95. Cas-1088-11-5

    96. 2h-1, 1,3-dihydro-7-chloro-5-phenyl-

    97. 2h-1, 7-chloro-1,3-dihydro-5-phenyl-

    98. Db-040846

    99. 5-phenyl-7-chloro-1,4-benzodiazepin-2-one

    100. 7-chloro-5-phenyl-3h-1,4-benzodiazepin-2-ol

    101. C07486

    102. D08283

    103. 7-chloro-5-phenyl-3h-1,4-benzodiazepin-2-one

    104. Nordazepam (nordiazepam) 0.1 Mg/ml In Methanol

    105. Nordazepam (nordiazepam) 1.0 Mg/ml In Methanol

    106. 088n115

    107. A801929

    108. Q3180288

    109. Dipotassium Clorazepate Impurity B [ep Impurity]

    110. 7-chloro-5-phenyl-1,3-dihydro-[1,4]benzodiazepin-2-one

    111. 7-chloro-5-phenyl-1h-benzo[e][1,4]diazepin-2(3h)-one

    112. (z)-7-chloro-5-phenyl-1h-benzo[e][1,4]diazepin-2(3h)-one

    113. 7-chloro-1,3 -dihydro-5-phenyl-2h-1,4-benzodiazepine-2-one

    114. 7-chloro-2,3-dihydro-5-phenyl-1h-1,4-benzodiazepin-2-one

    115. 7-chloro-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one #

    116. 7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one( Am)

    117. 7-chloro-5-phenyl-2-oxo-2,3-dihydro-1h-benzo[f]-1,4-diazepine

    118. Desmethyldiazepam Solution, Drug Standard, 1.0 Mg/ml In Methanol

    119. 7-chloro-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one (nordazepam)

    120. 7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one(nordiazepam)

    121. 7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one(desmethyldiazepam)

    122. Nordiazepam Solution, 1 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material

    123. Nordazepam; Desmethyl Amino Diazepam; 7-chloro-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 270.71 g/mol
    Molecular Formula C15H11ClN2O
    XLogP32.9
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count1
    Exact Mass270.0559907 g/mol
    Monoisotopic Mass270.0559907 g/mol
    Topological Polar Surface Area41.5 Ų
    Heavy Atom Count19
    Formal Charge0
    Complexity376
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Anxiety Agents

    Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

    GABA Modulators

    Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)

    4.2 ATC Code

    N05BA16

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    N - Nervous system

    N05 - Psycholeptics

    N05B - Anxiolytics

    N05BA - Benzodiazepine derivatives

    N05BA16 - Nordazepam

    4.3 Metabolism/Metabolites

    Nordiazepam has known human metabolites that include Oxazepam.

    Nordiazepam is a known human metabolite of diazepam.

    S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560