1. Capval
2. Capval Tropfen
3. Embonate, Noscapine Hydrogen
4. Hydrochloride, Noscapine
5. Hydrogen Embonate, Noscapine
6. Librochin Prikkelhoest
7. Narcotine
8. Noscapect
9. Noscapine Hydrochloride
10. Noscapine Hydrogen Embonate
11. Prikkelhoest, Librochin
12. Tropfen, Capval
13. Tuscalman
1. 128-62-1
2. Narcotine
3. Tusscapine
4. Methoxyhydrastine
5. Terbenol
6. Capval
7. Coscopin
8. Narcompren
9. Narcosine
10. Noscapin
11. Vadebex
12. (-)-narcotine
13. Narcotin
14. Narkotin
15. Noscapalin
16. Opianine
17. Opianin
18. Narcotussin
19. Longatin
20. Nectadon
21. Nicolane
22. Nipaxon
23. Lyobex
24. Opian
25. Alpha-narcotine
26. O-methylnarcotoline
27. Coscotabs
28. Noscapinum
29. Key-tusscapine
30. Longactin
31. Noscapal
32. Noscapina
33. Hederix (free Base)
34. (-)-alpha-narcotine
35. L-alpha-narcotine
36. Gnoscopine
37. Narcotinum
38. Noscopine
39. (-)-.alpha.-narcotine
40. Nsc 5366
41. Nsc-5366
42. .alpha.-narcotine
43. Dl-narcotine
44. (+/-)-noscapine
45. L-.alpha.-narcotine
46. A4c6we7bzn
47. 8v32u4aoqu
48. Alpha-gnoscopine
49. (3s)-6,7-dimethoxy-3-[(5r)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3h)-one
50. (s)-6,7-dimethoxy-3-((r)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3h)-one
51. Chebi:73237
52. Nsc5366
53. (3s)-6,7-dimethoxy-3-[(5r)-4-methoxy-6-methyl-7,8-dihydro-5h-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3h-2-benzofuran-1-one
54. Dsstox_cid_3385
55. Dsstox_rid_77007
56. Dsstox_gsid_23385
57. 1(3h)-isobenzofuranone, 6,7-dimethoxy-3-((5r)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (3s)-rel-
58. 1(3h)-isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)-isoquinolin-5-yl), (s-(r*,s*))-
59. 1(3h)-isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (r*,s*)-
60. 6035-40-1
61. Narcotine Alkaloid
62. Noskapin
63. .alpha.-gnoscopine
64. Noscapine Dl-form
65. L-alpha-noscapine
66. 8-methoxyhydrastin
67. Coscopin (van)
68. (3s)-6,7-dimethoxy-3-[(5r)-4-methoxy-6-methyl-2h,5h,6h,7h,8h-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-1,3-dihydro-2-benzofuran-1-one
69. Smr000059119
70. (+-)-noscapine
71. (-)-.alpha.-norcotine
72. (-)-alpha-norcotine
73. (+-)-alpha-narcotine
74. 1(3h)-isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (s-(r*,s*))-
75. 1(3h)-isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [s-(r*,s*)]-
76. Noscapinum [inn-latin]
77. Noscapina [inn-spanish]
78. Unii-a4c6we7bzn
79. Unii-8v32u4aoqu
80. Ccris 9304
81. Nsc-96350
82. Hsdb 3372
83. Noscapine [usp:inn:ban:jan]
84. .beta.-narcotine
85. Noscapine (tn)
86. (-)-noscapine
87. Ncgc00016388-01
88. [s-(r*,s*)]-6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3h)-isobenzofuranone
89. Cas-128-62-1
90. Prestwick_959
91. (-)-a-narcotine
92. Einecs 204-899-2
93. Nsc 96350
94. 1-.alpha.-narcotine
95. Brn 0099933
96. Tocris-1697
97. Narcotine, (+-)-
98. Noscapine [inn]
99. Noscapine [jan]
100. Noscapine [mi]
101. Noscapine [hsdb]
102. Prestwick0_000563
103. Prestwick1_000563
104. Prestwick2_000563
105. Prestwick3_000563
106. Narcotinum [hpus]
107. Cbmicro_048259
108. Noscapine [mart.]
109. Noscapine [usp-rs]
110. Noscapine [who-dd]
111. Noscapine [who-ip]
112. Schembl4559
113. (s,r)-noscapine, 97%
114. Lopac0_000840
115. Bspbio_000346
116. 4-27-00-06838 (beilstein Handbook Reference)
117. Mls000069475
118. Mls001060855
119. Spbio_002565
120. Noscapine (jp15/usp/inn)
121. Noscapine (jp17/usp/inn)
122. Bpbio1_000382
123. Chembl364713
124. Noscapine Dl-form [mi]
125. Dtxsid4023385
126. Noscapine [ep Monograph]
127. Noscapine, (+/-)-
128. Gtpl10212
129. Noscapine [usp Monograph]
130. Noscapinum [who-ip Latin]
131. Dtxsid901032089
132. Hms1569b08
133. Hms2096b08
134. Hms2269p05
135. 1(3h)-isobenzofuranone, 6,7-dimethoxy-3-((5r)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (3s)-
136. 6,7-dimethoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3h)-one, (s-(r*,s*))- #
137. Phthalide, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-
138. (+/-)-.alpha.-narcotine
139. Tox21_110413
140. Bbl012344
141. Bdbm50424716
142. Mfcd00069316
143. Nsc121869
144. Stk054401
145. Zinc19418974
146. Noscapine 1.0 Mg/ml In Acetonitrile
147. Akos000278036
148. Tox21_110413_1
149. Ccg-204096
150. Cs-5115
151. Db06174
152. Nsc-121869
153. Sdccgsbi-0048054.p004
154. (-)-3-(2-methyl-6,7-methylendioxy-8-methoxy-1-isochinolyl)-6,7-dimethoxyphthalid
155. Ncgc00023230-02
156. Ncgc00023230-04
157. Ncgc00023230-05
158. Ncgc00023230-07
159. Ncgc00023230-08
160. Ncgc00023230-10
161. Ncgc00023230-14
162. (3s)-6,7-dimethoxy-3-[(5r)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-2h-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3h)-one
163. (3s)-6,7-dimethoxy-3-[(5r)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3h)-isobenzofuranone
164. 5-(6,7-dimethoxyphthalidyl)-5,6,7,8-tetrahydro-4-methoxy-8-methyl-1,3-dioxolo(4,5-g)isoquinoline
165. Ac-20272
166. Ac-33191
167. Hy-13716
168. L-alpha-2-methyl-8-methoxy-6,7-methylenedioxy-1-(6,7-dimethoxy-3-phthalidyl)-1,2,3,4-tetrahydroisoquinaline
169. Nci60_004322
170. Vs-03291
171. Bim-0048054.p001
172. C09592
173. D01036
174. Sr-01000075529-6
175. W-201012
176. Brd-k89237706-001-03-8
177. Q60998699
178. Noscapine, European Pharmacopoeia (ep) Reference Standard
179. Noscapine, United States Pharmacopeia (usp) Reference Standard
180. Wln: T C566 Do Fo Kn Eh & & Tj Ho1 K1 J-dt56 Bvo Dhj Ho1 Io1
181. (3s)-3-[(5r)-6-methyl-4-(methyloxy)-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6,7-bis(methyloxy)-2-benzofuran-1(3h)-one
182. (3s)-6,7-dimethoxy-3-[(5r)-4-methoxy-6-methyl-7,8-dihydro-5h-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3h-isobenzofuran-1-one
183. 08n
184. 1(3h)-isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (r*,s*)-(+-)-
185. 1(3h)-isobenzofuranone,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [s-(r*,s*)]-
186. Phthalide,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-
| Molecular Weight | 413.4 g/mol |
|---|---|
| Molecular Formula | C22H23NO7 |
| XLogP3 | 2.7 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 4 |
| Exact Mass | 413.14745207 g/mol |
| Monoisotopic Mass | 413.14745207 g/mol |
| Topological Polar Surface Area | 75.7 Ų |
| Heavy Atom Count | 30 |
| Formal Charge | 0 |
| Complexity | 647 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Antitussive Agents
National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)
ANTITUSSIVE AGENT WHICH DEPRESSES MEDULLARY CENTERS & SUPPRESSES COUGH REFLEX. IT IS USED IN MGMNT OF COUGH IN BRONCHIAL ASTHMA & PULMONARY EMPHYSEMA. DRUG REDUCES FREQUENCY & INTENSITY OF COUGHING PAROXYSMS.
Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 805
DRUG HAS NO MORPHINE-LIKE EFFECTS & HAS NO EFFECT ON MORPHNE ABSTINENCE SYNDROME. TOLERANCE TO ANTITUSSIVE EFFECT HAS NOT BEEN OBSERVED. NOSCAPINE IS NO LONGER CONTROLLED UNDER FEDERAL NARCOTIC LAW.
Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 805
NOSCAPINE HAS NO ANALGESIC PROPERTIES OR DEPENDENCE LIABILITY.
American Medical Association, AMA Department of Drugs, AMA Drug Evaluations. 3rd ed. Littleton, Massachusetts: PSG Publishing Co., Inc., 1977., p. 667
NOSCAPINE HAD NO ANTITUSSIVE ACTIVITY IN VOLUNTEERS.
EMPEY ET AL; COMPARISON OF THE ANTITUSSIVE EFFECTS OF CODEINE PHOSPHATE 20 MG, DEXTROMETHORPHAN 30 MG AND NOSCAPINE 30 MG USING CITRIC ACID-INDUCED COUGH IN NORMAL SUBJECTS; EUR J CLIN PHARMACOL 16(6) 393 (1979)
THERAPEUTICALLY EFFECTIVE DOSES ARE ESSENTIALLY DEVOID OF UNPLEASANT SIDE EFFECTS OF CODEINE &, EXCEPT FOR OCCASIONAL NAUSEA, ITS SIDE EFFECTS ARE NEGLIGIBLE. DOSES UP TO 90 MG HAVE NO EFFECT ON RESPIRATION IN MAN.
Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 805
SIDE EFFECTS, PREDOMINANTLY GI, ARE SEEN IN UP TO 30% OF PT STUDIED.
Miller, R. R., and D. J. Greenblatt. Handbook of Drug Therapy. New York: Elsevier North Holland, 1979., p. 988
Maternal Medication usually Compatible with Breast-Feeding: Noscapine: Reported Sign or Symptom in Infant or Effect on Lactation: None. /from Table 6/
Report of the American Academy of Pediatrics Committee on Drugs in Pediatrics 93 (1): 141 (1994)
Investigated for use/treatment in lymphoma (non-hodgkin's), leukemia (lymphoid), cancer/tumors (unspecified), and multiple myeloma.
Antitussive Agents
Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally. (See all compounds classified as Antitussive Agents.)
R - Respiratory system
R05 - Cough and cold preparations
R05D - Cough suppressants, excl. combinations with expectorants
R05DA - Opium alkaloids and derivatives
R05DA07 - Noscapine
ITS ANTITUSSIVE POTENCY & ONSET & DURATION OF ACTION ARE APPROX EQUAL, MG FOR MG, TO THOSE OF CODEINE.
Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 805
MECONIN WAS THE MAJOR URINARY METABOLITE OF RATS, RABBITS, & HUMANS WHO HAD RECEIVED 120, 150 MG/KG & 10 MG, RESPECTIVELY, ORALLY. IT ACCOUNTED FOR APPROX 3, 8, & 2% OF DOSE RESPECTIVELY, AFTER 24 HR. O-DEMETHYLATED METABOLITES WERE ALSO FOUND.
TSUNODA, YOSHIMURA; XENOBIOTICA 9(3) 181 (1979)
Noscapine's antitussive effects appear to be primarily mediated by its sigma receptor agonist activity. Evidence for this mechanism is suggested by experimental evidence in rats. Pretreatment with rimcazole, a sigma specific antagonist, causes a dose-dependent reduction in antitussive activity of noscapine.
...EXCEPT FOR ITS ANTITUSSIVE EFFECT, IT HAS NO SIGNIFICANT ACTIONS ON CNS IN DOSES WITHIN THERAPEUTIC RANGE.
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 279
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