Please Wait
Applying Filters...
menu
    • menu
    Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

    Virtual Booth

    Contact Supplier

    TransoPharm USA works in the Sourcing and Management of Active Pharmaceutical Ingredients.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2025-01-06

    Virtual Booth

    Contact Supplier

    LEBSA- Your strategic API source for niche molecules.

    Virtual Booth

    Contact Supplier

    Nuray is an expert in the synthesis of Niche novel APIs, the first to launch Generics, NCEs, Advanced Intermediates // USFDA certified.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2025-01-06

    Virtual Booth

    Contact Supplier

    Menu

    Obefazimod

    DEVELOPMENTS

    DIGITAL CONTENT

    PharmaCompass
    Xls

    Filters

    clear-filterReset all filters
    2D Structure
    Also known as: Abx-464, Abx464, Obefazimod, 1258453-75-6, Spl-464, Obefazimod [usan]
    Molecular Formula
    C16H10ClF3N2O
    Molecular Weight
    338.71  g/mol
    InChI Key
    OZOGDCZJYVSUBR-UHFFFAOYSA-N
    FDA UNII
    26RU378B9V
    Obefazimod is an orally available, small molecule binder of the cap binding complex (CBC) 80/20, with potential antiviral and anti-inflammatory activities. Upon oral administration, obefazimod binds to the CBC, a complex at the 5'-end of the pre-mRNA transcript that promotes the initial interaction with transcription and processing machinery. This leads to a conformational change in the CBC and enhanced splicing of viral RNA variants and upregulation of the anti-inflammatory microRNA, miR-124, via splicing of a long noncoding RNA at the miR-124-1 locus. In human immunodeficiency virus type 1 (HIV-1)-infected cells, obefazimod interacts with the CBC of HIV-1 mRNA and inhibits viral replication by preventing Rev-mediated export of unspliced HIV-1 transcripts to the cytoplasm. Rev facilitates the nuclear export of unspliced or incompletely spliced viral pre-mRNAs, an essential step in HIV-1 replication. In inflammatory conditions, miR-124 reduces the production of various inflammatory mediators, including interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and C-C motif chemokine 2 (CCL2; MCP-1.). miR-124 plays a critical role in innate and adaptive immune responses and is a critical mediator of cholinergic anti-inflammatory action.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    8-chloro-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine
    2.1.2 InChI
    InChI=1S/C16H10ClF3N2O/c17-13-3-1-2-10-4-9-14(22-15(10)13)21-11-5-7-12(8-6-11)23-16(18,19)20/h1-9H,(H,21,22)
    2.1.3 InChI Key
    OZOGDCZJYVSUBR-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC2=C(C(=C1)Cl)N=C(C=C2)NC3=CC=C(C=C3)OC(F)(F)F
    2.2 Other Identifiers
    2.2.1 UNII
    26RU378B9V
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Abx464

    2.3.2 Depositor-Supplied Synonyms

    1. Abx-464

    2. Abx464

    3. Obefazimod

    4. 1258453-75-6

    5. Spl-464

    6. Obefazimod [usan]

    7. 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine

    8. 26ru378b9v

    9. 2-quinolinamine, 8-chloro-n-(4-(trifluoromethoxy)phenyl)-

    10. Obefazimod [inn]

    11. Unii-26ru378b9v

    12. Schembl1705888

    13. Abx-464 [who-dd]

    14. Chembl4297344

    15. Gtpl11698

    16. Ex-a3322

    17. Who 12112

    18. Db14828

    19. Mmv1581032

    20. Sb18690

    21. Ac-35811

    22. Bs-14770

    23. Abx464(abx-464;abx 464)

    24. Hy-100870

    25. Cs-0020537

    26. S0076

    27. A16912

    28. D84095

    29. Q27896117

    2.4 Create Date
    2011-01-31
    3 Chemical and Physical Properties
    Molecular Weight 338.71 g/mol
    Molecular Formula C16H10ClF3N2O
    XLogP35.9
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count3
    Exact Mass338.0433751 g/mol
    Monoisotopic Mass338.0433751 g/mol
    Topological Polar Surface Area34.2 Ų
    Heavy Atom Count23
    Formal Charge0
    Complexity388
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1