1. 1-octadecanol
1. 1-octadecanol
2. Octadecan-1-ol
3. Octadecanol
4. 112-92-5
5. 1-hydroxyoctadecane
6. Octadecyl Alcohol
7. N-octadecanol
8. N-1-octadecanol
9. Stearol
10. N-octadecyl Alcohol
11. Stearic Alcohol
12. Atalco S
13. Alfol 18
14. Alcohol Stearylicus
15. Steraffine
16. Polaax
17. Stenol
18. Crodacol-s
19. Aldol 62
20. Siponol S
21. Siponol Sc
22. Lanol S
23. Sipol S
24. Adol 68
25. Decyl Octyl Alcohol
26. Cachalot S-43
27. Lorol 28
28. 1-0ctadecanol
29. Dytol E-46
30. Usp Xiii Stearyl Alcohol
31. Stearylalkohol
32. Tego Alkanol 18
33. Rita Sa
34. Co-1895
35. Lanette 18
36. Hainol 18ss
37. Alcohols, C18-32
38. Custom Stearyl
39. Ultrapure S
40. Oristar Sa
41. Octadecanol Nf
42. Lipocol S-deo
43. Lipocol S
44. Stearyl Alcohol S
45. Crodacol S95
46. Stearyl Alcohol Pc
47. Unihydag Wax-18
48. Aec Stearyl Alcohol
49. Alfol 18 Alcohol
50. Crodacol S-95
51. Co-1897
52. Nacol 18do Alcohol
53. Nikkol Stearyl Alcohol
54. Sabonal C 18 95
55. Nacol 18-94 Alcohol
56. Nacol 18-98 Alcohol
57. Nacol 18-99 Alcohol
58. Nsc-5379
59. Mfcd00002823
60. 2kr89i4h1y
61. Chebi:32154
62. Nsc5379
63. 68911-61-5
64. Ncgc00159369-02
65. Ncgc00159369-04
66. Octadecylalkohol
67. Dsstox_cid_6935
68. Dsstox_rid_78262
69. Octadecanol, 1-
70. Dsstox_gsid_26935
71. C18 Alcohol
72. Alcohol(c18)
73. Fatty Alcohol(c18)
74. Rofamol
75. Crodacol S
76. 1-stearyl Alcohol
77. Cas-112-92-5
78. Kalcohl 80
79. Ccris 3960
80. Conol 30f
81. Kalcohl 8098
82. Hsdb 1082
83. Adol 62
84. Conol 1675
85. Nsc 5379
86. Einecs 204-017-6
87. Stearyl Alcohol [jan:nf]
88. Brn 1362907
89. Stearylalcohol
90. Unii-2kr89i4h1y
91. Octanodecanol
92. Stearal
93. Ai3-01330
94. N-octadecylalcohol
95. Varonic Bg
96. Crodacol S70
97. Crodacol S95nf
98. Stearyl Alcohol Nf
99. Co 1895f
100. Einecs 272-778-1
101. Stearyl Alcohol Pure
102. Aec Cetearyl Alcohol
103. Cachalot S-56
104. Philcohol 1800
105. Stearyl Alcohol Usp
106. C18 Linear Alcohol
107. Lanette 18 Deo
108. Crodacol 1618
109. Lorol C18
110. Octadecenol-
111. Alfol 1618 Alcohol
112. Alcohol Cetylstearylicus
113. Alfol 1618e Alcohol
114. Alfol 1618cg Alcohol
115. 1-octadecanol, 95%
116. Ssd Af (salt/mix)
117. Ec 204-017-6
118. Ceteareth-20 (salt/mix)
119. Schembl23810
120. Octadecanol [who-dd]
121. Stearyl Alcohol [ii]
122. Stearyl Alcohol [mi]
123. 4-01-00-01888 (beilstein Handbook Reference)
124. Chembl24640
125. Stearyl Alcohol (jp17/nf)
126. Stearyl Alcohol [jan]
127. Stearyl Alcohol 98/f
128. Stearyl Alcohol 98/p
129. Stearyl Alcohol [hsdb]
130. Stearyl Alcohol [inci]
131. Wln: Q18
132. Stearyl Alcohol [vandf]
133. Dtxsid8026935
134. Schembl10409854
135. Stearyl Alcohol [mart.]
136. (c18-c32)alcohol Fraction (distillation Column Bottoms)
137. Stearyl Alcohol [usp-rs]
138. Stearyl Alcohol [who-dd]
139. Cs-d1671
140. Hy-y1809
141. Zinc8214679
142. Tox21_111610
143. Lmfa05000085
144. Stl453659
145. 1-octadecanol, Technical Grade, 80%
146. Akos009031494
147. Cachalot S-56 Stearyl Alcohol
148. Stearyl Alcohol [ep Monograph]
149. Tox21_111610_1
150. 1-octadecanol, Reagentplus(r), 99%
151. Ncgc00159369-03
152. Sy011369
153. 1-octadecanol, Puriss., >=99.0% (gc)
154. Ft-0761208
155. O0006
156. 1-octadecanol, Selectophore(tm), >=99.5%
157. 1-octadecanol, Vetec(tm) Reagent Grade, 94%
158. D01924
159. A802702
160. L000755
161. Q632384
162. Sr-01000944718
163. J-002873
164. Sr-01000944718-1
165. Stearyl Alcohol, European Pharmacopoeia (ep) Reference Standard
166. 2def44b7-b367-4188-89e4-531379568c74
167. Stearyl Alcohol, United States Pharmacopeia (usp) Reference Standard
168. Stearyl Alcohol, Pharmaceutical Secondary Standard; Certified Reference Material
| Molecular Weight | 270.5 g/mol |
|---|---|
| Molecular Formula | C18H38O |
| XLogP3 | 8.4 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 16 |
| Exact Mass | 270.292265831 g/mol |
| Monoisotopic Mass | 270.292265831 g/mol |
| Topological Polar Surface Area | 20.2 Ų |
| Heavy Atom Count | 19 |
| Formal Charge | 0 |
| Complexity | 145 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Stearyl alcohol is found naturally in various mammalian tissues ... Results from several studies indicate that stearyl alcohol is poorly absorbed from the gastrointestinal tract.
Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 6:496
Several studies indicate that /1-octadecanol/ is poorly absorbed from the gastrointestinal tract. The entry of 14C-octadecanol into the thoracic lymph duct of the Sprague-Dawley rat was reported. Lymph flows and blood were monitored for radioactivity in different intervals following dosing. Intestinal radioactivity was determined in the intestinal homogenate which showed the percent absorbed radioactivity in the lymph was 56.6 +/- 14.0. Of this, more than half was found in the triglycerides of the lymph, 6 to 13 % in the phospholipids, 2 to 8% as the cholesterol esters, and 4 to 10% unchanged octadecanol. 90% of octadecanol was found in the lipomicrom fraction of the blood. The absorption of the compound appeared to be a function of its lipid solubility.
European Chemicals Bureau; IUCLID Dataset, 1-Octadecanol (112-92-5) (2000 CD-ROM edition). Available from, as of April 20, 2006: https://esis.jrc.ec.europa.eu/
Stearyl alcohol ... is used in the biosynthesis of lipids and other naturally occurring cellular constituents and enters metabolic pathways for energy production. This fatty alcohol is readily converted to stearic acid, another common constituent of mammalian tissue.
Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 6:496
From the absorbed fraction more than half was metabolized to triglycerides, 6-13% to phospholipids, 2- 8% to cholesterol esters, and 4-10% remained as unchanged octadecanol after 24h period, from dosing.
OECD; Screening Information Data Set for 1-Octadecanol 112-92-5. Available from, as of April 21, 2006: https://www.inchem.org/documents/sids/sids/112925.pdf
... Ethanol, 1-propanol, 1-butanol, 1-pentanol and 1-octanol had essentially the same effects on the mitochondrial ultrastructure: a mixed population of small and enlarged mitochondria with poorly developed cristae; 1-dodecanol induced ultrastructural changes of mitochondria of two distinct types: a mixed population of small and enlarged mitochondria with poorly developed cristae in some hepatocytes and remarkably enlarged mitochondria with well-developed cristate in others; and 1-octadecanol induced remarkably enlarged mitochondria in all hepatocytes.
Wakabayashi T et al; Acta Pathol Jpn 41(6): 405-13 (1991)
... The reactivity of the fatty alcohols with cetrimide decreased with increasing chain length although branching on the tetradecanol and hexadecanol resulted in a higher reactivity. Adding 1-octadecanol to 1-hexadecanol resulted in an increased reactivity rising to a maximum for mixtures containing 20-40% w/w 1-octadecanol.
Rowe RC; J Pharm Pharmacol 39 (1): 50-2 (1987)
... Peak inhibition was recorded with saturated primary alcohols (64 microM) varying in chain length from 16 to 19 carbon atoms. The unsaturated alcohols (oleyl, linoleyl, and linolenyl) and the secondary alcohol (pentadecan-2-ol) were considerably less effective growth inhibitors. Stearic and palmitic acids were also ineffective.
Fletcher RD et al; Antimicrob Agents Chemother 19 (5): 917-21 (1981)
After incubation of stationary phase Leishmania donovani with [1-14C]octadecanol, about 70% of the precursor was taken up within 3 hr. Wax esters and acyl moieties of glycerolipids contained most of the 14C-activity from 3 to 6 hr, because octadecanol was partly oxidized to stearate. Ether moieties were only weakly labeled. After 40 hr, 1-0-alkyl and 1-0-alk-1'-enyl diacylglycerols as well as 1-0-alkyl and 1-0-alk-1'-enyl-2-acyl-sn-glycero-3-phosphoethanolamines contained nearly all of the radioactivity. Most of the label in the neutral ether lipids was located in the alkyl ether side chain, whereas, in the phosphatidylethanolamine fraction, most of the label was found in the alkenyl ether side chain.
Herrmann H, Gercken G; Lipids 15 (3): 179-85 (1980)
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