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    Omecamtiv Mecarbil

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

    DIGITAL CONTENT

    PharmaCompass
    Xls

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    2D Structure
    Also known as: 873697-71-3, Omecamtiv mecarbil (ck-1827452), Ck-1827452, Methyl 4-(2-fluoro-3-(3-(6-methylpyridin-3-yl)ureido)benzyl)piperazine-1-carboxylate, Ck1827452, Ck 1827452
    Molecular Formula
    C20H24FN5O3
    Molecular Weight
    401.4  g/mol
    InChI Key
    RFUBTTPMWSKEIW-UHFFFAOYSA-N
    FDA UNII
    2M19539ERK
    Omecamtiv Mecarbil has been used in trials studying the treatment and basic science of Heart Failure, Echocardiogram, Pharmacokinetics, Chronic Heart Failure, and History of Chronic Heart Failure, among others.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    methyl 4-[[2-fluoro-3-[(6-methylpyridin-3-yl)carbamoylamino]phenyl]methyl]piperazine-1-carboxylate
    2.1.2 InChI
    InChI=1S/C20H24FN5O3/c1-14-6-7-16(12-22-14)23-19(27)24-17-5-3-4-15(18(17)21)13-25-8-10-26(11-9-25)20(28)29-2/h3-7,12H,8-11,13H2,1-2H3,(H2,23,24,27)
    2.1.3 InChI Key
    RFUBTTPMWSKEIW-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=NC=C(C=C1)NC(=O)NC2=CC=CC(=C2F)CN3CCN(CC3)C(=O)OC
    2.2 Other Identifiers
    2.2.1 UNII
    2M19539ERK
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Amg-423

    2. Ck 1827452

    3. Ck-1827452

    2.3.2 Depositor-Supplied Synonyms

    1. 873697-71-3

    2. Omecamtiv Mecarbil (ck-1827452)

    3. Ck-1827452

    4. Methyl 4-(2-fluoro-3-(3-(6-methylpyridin-3-yl)ureido)benzyl)piperazine-1-carboxylate

    5. Ck1827452

    6. Ck 1827452

    7. Amg-423

    8. Methyl 4-[[2-fluoro-3-[(6-methylpyridin-3-yl)carbamoylamino]phenyl]methyl]piperazine-1-carboxylate

    9. Chembl1800955

    10. 2m19539erk

    11. Ck-452

    12. Methyl 4-[[2-fluoro-3-[n'-(6-methylpyridin-3-yl)ureido]phenyl]methyl]piperazine-1-carboxylate

    13. Methyl 4-(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}benzyl)piperazine-1-carboxylate

    14. 1-piperazinecarboxylic Acid, 4-((2-fluoro-3-((((6-methyl-3-pyridinyl)amino)carbonyl)amino)phenyl)methyl)-, Methyl Ester

    15. Methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate

    16. Omecamtiv Mecarbil [usan]

    17. Unii-2m19539erk

    18. Omecamtiv Mecarbil [usan:inn]

    19. Omecamtiv-mecarbil

    20. Omecamtiv Mercarbil

    21. Methyl 4-((2-fluoro-3-(((6-methylpyridin-3-yl)carbamoyl)amino)phenyl)methyl)piperazine-1-carboxylate

    22. Mls006011266

    23. Schembl400544

    24. Gtpl8740

    25. Omecamtiv Mecarbil (usan/inn)

    26. Omecamtiv Mecarbil [inn]

    27. Amg 423

    28. Ex-a714

    29. Chebi:188664

    30. Bcpp000140

    31. Ck-1827452;omecamtiv Mecarbil

    32. Dtxsid901025949

    33. Hms3656f05

    34. Bcp03048

    35. Omecamtiv Mecarbil [who-dd]

    36. Bdbm50348423

    37. Mfcd18633260

    38. Zinc38253214

    39. Akos026674125

    40. Bcp9001023

    41. Ccg-268662

    42. Cs-0460

    43. Db11816

    44. Sb16684

    45. Ncgc00346618-01

    46. Ncgc00346618-02

    47. Ncgc00346618-07

    48. Ac-32748

    49. As-60560

    50. Hy-14233

    51. Smr004703017

    52. Bcp0726000250

    53. Ft-0700389

    54. S2623

    55. Sw219490-1

    56. D09648

    57. F15273

    58. Omecamtiv Mecarbil;ck-1827452;ck 1827452

    59. J-690376

    60. Q7089956

    61. Methyl 4-((2-fluoro-3-(((6-methylpyridin-3-yl)carbamoyl)amino)phenyl)methyl) Piperazine-1-carboxylate

    62. Methyl 4-[[2-luoro-3-[(6-methylpyridin-3-yl)carbamoylamino]phenyl]methyl]piperazine-1-carboxylate

    2.4 Create Date
    2006-10-26
    3 Chemical and Physical Properties
    Molecular Weight 401.4 g/mol
    Molecular Formula C20H24FN5O3
    XLogP31.4
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count5
    Exact Mass401.18631781 g/mol
    Monoisotopic Mass401.18631781 g/mol
    Topological Polar Surface Area86.8 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity558
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Treatment of heart failure