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    Oteracil Potassium

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

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    2D Structure
    Also known as: 2207-75-2, Oteracil potassium, Oxonic acid potassium salt, Allantoxanic acid potassium salt, Potassium azaorotate, Oxonic acid, potassium salt
    Molecular Formula
    C4H2KN3O4
    Molecular Weight
    195.17  g/mol
    InChI Key
    IAPCTXZQXAVYNG-UHFFFAOYSA-M
    FDA UNII
    4R7FFA00RX
    Oteracil Potassium is the potassium salt of oxonate, an enzyme inhibitor that modulates 5- fluorouracil (5-FU) toxicity. Potassium oxonate inhibits orotate phosphoribosyltransferase, which catalyzes the conversion of 5-FU to its active or phosphorylated form, FUMP. Upon oral administration, Oxonate is selectively distributed to the intracellular sites of tissues lining the small intestines, producing localized inhibitory effects within the gastrointestinal tract. As a result, 5-FU associated gastrointestinal toxic effects are reduced and the incidence of diarrhea or mucositis is decreased in 5-FU related therapy.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    potassium;4,6-dioxo-1H-1,3,5-triazine-2-carboxylate
    2.1.2 InChI
    InChI=1S/C4H3N3O4.K/c8-2(9)1-5-3(10)7-4(11)6-1;/h(H,8,9)(H2,5,6,7,10,11);/q;+1/p-1
    2.1.3 InChI Key
    IAPCTXZQXAVYNG-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    C1(=NC(=O)NC(=O)N1)C(=O)[O-].[K+]
    2.2 Other Identifiers
    2.2.1 UNII
    4R7FFA00RX
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. 2207-75-2

    2. Oteracil Potassium

    3. Oxonic Acid Potassium Salt

    4. Allantoxanic Acid Potassium Salt

    5. Potassium Azaorotate

    6. Oxonic Acid, Potassium Salt

    7. Potassium 4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazine-2-carboxylate

    8. Oxonate

    9. Potassium 2,6-dihydroxytriazinecarboxylate

    10. Potassium 4,6-dihydroxy-1,3,5-triazine-2-carboxylate

    11. Oxonate, Potassium

    12. 4r7ffa00rx

    13. Oxonic Acid (potassium Salt)

    14. Chebi:80230

    15. Mfcd00010565

    16. Allantoxanic Acid, Potassium Salt

    17. Allantoxanic Acid, Monopotassium Salt

    18. Potassiumoxonate

    19. Nsc28841

    20. Nsc-28841

    21. Potassium Allantoxanate

    22. Ncgc00166236-01

    23. 5-azaoroticacid,potassiumsalt

    24. Potassium Otastat

    25. 5-azaorotic Acid, Potassium Salt

    26. Potassium 1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazine-2-carboxylate

    27. Einecs 218-627-5

    28. Nsc 28841

    29. Potassium 4,6-dioxo-1h-1,3,5-triazine-2-carboxylate

    30. Potassium S-triazine-2,4-dione-6-carboxylate

    31. Unii-4r7ffa00rx

    32. Dsstox_cid_26568

    33. Dsstox_rid_81727

    34. Dsstox_gsid_46568

    35. Kox

    36. Schembl339417

    37. Oteracil Potassium[jan]

    38. Chembl3184847

    39. Dtxsid5046568

    40. Oteracil Potassium [jan]

    41. Act04739

    42. Amy40569

    43. Bcp06172

    44. Oteracil Potassium [who-dd]

    45. Tox21_112362

    46. 1,4,5,6-tetrahydro-4,6-dioxo-s-triazine-2-carboxylic Acid, Potassium Salt

    47. Akos006229816

    48. Akos015961942

    49. Akos015964230

    50. Akos025116606

    51. Ac-2039

    52. 1,3,5-triazine-2-carboxylic Acid, 1,4,5,6-tetrahydro-4,6-dioxo-, Monopotassium Salt

    53. S-1 Component Oteracil Potassium

    54. As-13301

    55. Hy-17511

    56. Sy036250

    57. Cas-2207-75-2

    58. Teysuno Component Oteracil Potassium

    59. Db-010118

    60. Ft-0603597

    61. O0164

    62. Oteracil Potassium Component Of Teysuno

    63. F14898

    64. Q-100280

    65. Q27149343

    66. Potassium;4,6-dioxo-1h-1,3,5-triazine-2-carboxylate

    2.4 Create Date
    2005-07-19
    3 Chemical and Physical Properties
    Molecular Weight 195.17 g/mol
    Molecular Formula C4H2KN3O4
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count1
    Exact Mass194.96823704 g/mol
    Monoisotopic Mass194.96823704 g/mol
    Topological Polar Surface Area111 Ų
    Heavy Atom Count12
    Formal Charge0
    Complexity274
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2